Antiflammin P1
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Basic information
- CAS
118850-71-8- Standard SMILES
CSCCC(NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCSC)C(=O)N[C@@H](CCCCN)C(=O)NC(CCCCN)C(=O)N[C@H](C(=O)NC(CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)O)C(C)C- InChIKey
XVZUZGWPOCVGGZ-NETRMLAPSA-N- Molecular formula
- C45H82N12O14S2
- Average molar mass
- 1,079.3 g/mol
- Monoisotopic mass
- 1,078.55148768
Overview
nonapeptide fragment of uteroglobin has no phospholipase A2 inhibitory & anti-inflammatory activity; RN given refers to all (L)-isomer
Names & identifiers
- Preferred name
- Antiflammin P1
- IUPAC
- (3S)-3-[[2-[[(2S)-2-[[6-amino-2-[[(2S)-6-amino-2-[[2-[[(2S)-5-amino-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-5-oxopentanoyl]amino]-4-methylsulfanylbutanoyl]amino]hexanoyl]amino]hexanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-[[(1S)-1-carboxy-2-hydroxyethyl]amino]-4-oxobutanoic acid
- English name
- ANTI-INFLAMMATORY PEPTIDE 1
- Molecular formula
- C45H82N12O14S2
- Molecular weight
- 1079.34
Names & synonyms
Antiflammin P1MqmkkvldsAntiflammin 1Antiflamin 1MET-GLN-MET-LYS-LYS-VAL-LEU-ASP-SER118850-71-8Methionyl-glutaminyl-methionyl-lysyl-lysyl-valyl-leucyl-aspartyl-serineRefChem:915983SCHEMBL29389069(3S)-3-[[2-[[(2S)-2-[[6-amino-2-[[(2S)-6-amino-2-[[2-[[(2S)-5-amino-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-5-oxopentanoyl]amino]-4-methylsulfanylbutanoyl]amino]hexanoyl]amino]hexanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-[[(1S)-1-carboxy-2-hydroxyethyl]amino]-4-oxobutanoic acidL-Serine, N-(N-(N-(N-(N2-(N2-(N-(N2-L-methionyl-L-glutaminyl)-L-methionyl)-L-lysyl)-L-lysyl)-valyl)-L-leucyl)-L-alpha-aspartyl)-PEPTIDE 1
Show more names
antiflamminp1Antiflammin-1ANTIFLAMMIN-IAF-1【peptide】ANTIFLAMMIN P IANTI-INFLAMMATORY PEPTIDE 1H-MET-GLN-MET-LYS-LYS-VAL-LEU-ASP-SER-OH
Properties
Computed structural propertiesFilling in
- XLogP
- -7.3
- Topological polar surface area
- 499 Ų
- Hydrogen bond donors
- 15
- Hydrogen bond acceptors
- 19
- Rotatable bonds
- 40
- Heavy atoms
- 73
- Formal charge
- 0
- Complexity
- 1,820
Physicochemical properties
- Boiling point
- 1490.7 · 1490.7±65.0 °C(Predicted)
- Density
- 1.27 · 1.270±0.06 g/cm3(Predicted)
- storage temp.
- 20 °C · −20°C
- solubility
- 107.9 mg/mL · ≥107.9 mg/mL in DMSO; insoluble in EtOH; ≥21.13 mg/mL in H2O
- pka
- 2.85 · 2.85±0.10(Predicted)
- form
- Lyophilized powder
- Sequence
- H-Met-Gln-Met-Lys-Lys-Val-Leu-Asp-Ser-OH
- WGK Germany
- 3 · 3
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- wgk
- 3
Chemistry & industry
Applications
UsesAntiflammin-1 is an anti-inflammatory peptide 1 (MQMKKVLDS). Antiflammin-1 is a derivative of uteroglobin. Antiflammin-1 has anti-inflammatory and antifibrotic actions in bleomycin (HY-108345)-induced lung injury[1][2][3].
Related reactions
0 records
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Compound notes
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