Cresyl glycidyl ether

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SMALL SPILLS AND LEAKAGE: If you spill this chemical, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with alcohol followed by washing with a strong soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 67(SRC), determined from a structure estimation method(2), indicates that cresyl glycidyl ether is expected to have high mobility in soil(SRC). Volatilization of cresyl glycidyl ether from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 7.6X10-7 atm-cu m/mole(SRC), using a fragment constant estimation method(3). Epoxides in general hydrolyze rapidly at 25 °C and pH 7(4) through neutral, acid, or base-mediated reactions(5). Cresyl glycidyl ether is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 4.3X10-2 mm Hg(SRC), determined from a fragment constant method(6). Biodegradation data were not available(SRC, 2006).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 67(SRC), determined from a structure estimation method(2), indicates that cresyl glycidyl ether is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected to be an important environmental fate process(3) based upon an estimated Henry's Law constant of 7.6X10-7 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), an estimated BCF of 9(SRC), from an estimated log Kow of 2.2(6), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Epoxides in general hydrolyze rapidly at 25 °C and pH 7(7) through neutral, acid, or base-mediated reactions(8). Hydrolysis products are usually the corresponding diol and sometimes re-arranged products(8). While data specific to cresyl glycidyl ether were not located(SRC, 2006), the hydrolysis half-life for an analogous compound glycidyl alcohol is 28 days at pH 7(7). Biodegradation data were not available(SRC, 2006). However, a 33% theoretical BOD using the Japanese MITI test for analogous phenyl glycidyl ether(9) suggests that biodegradation of cresyl glycidyl ether may occur in aquatic environments(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), cresyl glycidyl ether, which has an estimated vapor pressure of 4.3X10-2 mm Hg at 25deg C(SRC), determined from a fragment constant method(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase cresyl glycidyl ether is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 11 hrs(SRC), calculated from its rate constant of 3.4X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of cresyl glycidyl ether can be estimated to be 67(SRC). According to a classification scheme(2), this estimated Koc value suggests that cresyl glycidyl ether is expected to have high mobility in soil.

/HUMAN EXPOSURE STUDIES/ Epoxy resin systems (ERSs) are a frequent cause of occupational allergic contact dermatitis. Sensitization occurs not only to the resins, but also to hardeners and reactive diluents. However, only a fraction of the ERS components currently in use are available for patch testing. With the multicentre study EPOX 2002, we attempted to improve diagnostics in this field by patch testing with components currently used in ERSs. During the first study period (October 2002 to July 2003), in addition to commercially available ERS patch test substances, 16 study substances (1 resin, 9 hardeners and 6 reactive diluents) were patch tested in 70 patients with suspected contact allergy due to ERSs and 22 patients with a prior positive patch test reaction to epoxy resin (ER) in the standard series. Most frequently, allergic reactions to ER based on diglycidyl ether of bisphenol A and F were observed (55.2% and 43.7%, respectively). Agreement between positive reactions to both resins, which can be explained by immunological cross-sensitization and/or coexposure, was substantial [Cohen's kappa 0.65 (95% CI: 0.49-0.80)]. Among the reactive diluents, 1,6-hexanediol diglycidyl ether (1,6-HDDGE) and 1,4-butanediol diglycidyl ether (1,4-BDDGE) were the most frequent allergens, with 19.5% and 18.4% positive reactions, respectively. Although agreement between positive reactions to 1,6-HDDGE and 1,4-BDDGE was even better than with the 2 resins, the sample size is considered too small to decide reliably whether 1,6-HDDGE alone could serve as a marker allergen for both. Allergic reactions to p-tert-butylphenyl glycidyl ether and to phenyl glycidyl ether (PGE) occurred in 11.5% of the patients tested, with only moderate agreement. All patients positive to cresyl glycidyl ether (6.8%) also reacted to PGE. Of the hardeners tested, m-xylylene diamine was the most frequent allergen (13.8%), followed by isophorone diamine (5.7%). No reactions were observed to several substances, the test concentration of which may have been too low and will be increased in the future.

/SIGNS AND SYMPTOMS/ Cresyl glycidyl ether is a mild irritant and may cause dermatitis.

/SIGNS AND SYMPTOMS/ Cresyl glycidyl ether and o-cresyl glycidyl ether are potent skin sensitizers in humans.

/CASE REPORTS/ A case of contact urticaria due to epoxy resin and reactive diluents was described. A 23 year old male with a 6 month history of pruritis and urticarial weals on the face and upper limbs, occasionally accompanied by angioderma of the lips and tongue, and transient laryngeal constriction was evaluated. He reported being employed for 2 years as a part fitter in an aircraft factory where he was regularly exposed to epoxy products and solvents such as naphtha (8030306) and 1,1,1-trichloroethane (71556). His symptoms would develop within 20 minutes of exposure to epoxy compounds and were worse when he was working within a closed section of fuselage. The symptoms resolved within about 2 hours after exposure ended. Patch testing was performed with the European standard allergen series and epoxy, acrylate, isocyanates, and plastics and glues series. The patient was also tested with a special series of 15 epoxy compounds, hardeners, and solvents which he used at work. The patches were read after 30 minutes and 4 days. Urticarial reactions were observed after 30 minutes to epoxy resin and the reactive diluents phenylglycidyl-ether (122601) and cresylglycidyl-ether (26447143). No delayed reactions were seen at the 4 day reading. The patient agreed to be retested with the three substances. Retesting produced similar urticarial lesions, which were also accompanied by pharyngeal tingling and hoarseness. Oral treatment with 10 milligrams loratadine (79794755) cleared the lesions within 60 minutes. The author notes that contact urticaria caused by epoxy compounds has been infrequently reported. However, this is the first reported case of contact urticaria being caused by reactive diluents.

AEROBIC: Biodegradation data for cresyl glycidyl ether were not available(SRC, 2006). However, a 33% theoretical BOD using the Japanese MITI test for analogous phenyl glycidyl ether(1) suggests that biodegradation of cresyl glycidyl ether may occur in aquatic environments(SRC).

An estimated BCF of 9 was calculated for cresyl glycidyl ether(SRC), using an estimated log Kow of 2.2(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Henry's Law constant for cresyl glycidyl ether is estimated as 7.6X10-7 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that cresyl glycidyl ether is not expected to volatilize from water surfaces(2). Cresyl glycidyl ether's Henry's Law constant indicates that volatilization from moist soil surfaces is not expected to occur(SRC). Cresyl glycidyl ether is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 4.3X10-2 mm Hg(SRC), determined from a fragment constant method(3).

/LABORATORY ANIMALS: Acute Exposure/ Undiluted o-Cresyl glycidyl ether produced severe skin irritation at 24 hr, which progressed to necrosis by 14 days. Following a 4-hr semioccluded exposure o-cresyl glycidyl ether caused slight irritation to the skin with a complete recovery of the irritant effects within 7 days. /o-Cresyl glycidyl ether/

/LABORATORY ANIMALS: Acute Exposure/ Signs of /acute oral/ toxicity /in rats/ included dyspnea and lacrimation, and congested liver was observed at necropsy ...

/LABORATORY ANIMALS: Acute Exposure/ Signs of intoxication /in rats/ were ataxia and general depression. Dermal exposure resulted in severe dermal irritation. /o-Cresyl glycidyl ether/

/LABORATORY ANIMALS: Acute Exposure/ /Cresyl glycidyl ether/ is a moderate skin irritant in rabbits ...

For more Non-Human Toxicity Excerpts (Complete) data for CRESYL GLYCIDYL ETHER (21 total), please visit the HSDB record page.

The rate constant for the vapor-phase reaction of cresyl glycidyl ether with photochemically-produced hydroxyl radicals has been estimated as 3.4X10-11 cu cm/molecule-sec at 25 °C(SRC), using a structure estimation method(1). This corresponds to an atmospheric half-life of about 11 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Glycidyl ethers, such as cresyl glycidyl ether, can react readily with water and with nucleophiles such as proteins and nucleic acids(2). Epoxides in general hydrolyze rapidly at 25 °C and pH 7(3) through neutral, acid, or base-mediated reactions(4). Hydrolysis products are usually the corresponding diol and sometimes re-arranged products(4). While data specific to cresyl glycidyl ether were not located(SRC, 2006), the hydrolysis half-life for an analogous compound glycidyl alcohol is 28 days at pH 7(3).

Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Oxirane, ((methylphenoxy)methyl)- is included on this list.

Used as a reactive diluent for epoxy resin systems; [HSDB]

Plastic Composites Manufacturing [Category: Industry]

..As a reactive diluent for viscosity reduction of liquid epoxy resin systems, to increase the level of filler loading of such systems, and to reduce the tendency of the resins to crystallize

(1986) 10 thousand-500 thousand pounds[US EPA; Non-confidential Production Volume Information Submitted by Companies for Chemicals Under the 1986-2002 Inventory Update Rule (IUR). Oxirane,

(1994) 10 thousand-500 thousand pounds[US EPA; Non-confidential Production Volume Information Submitted by Companies for Chemicals Under the 1986-2002 Inventory Update Rule (IUR). Oxirane,

(1998) 10 thousand-500 thousand pounds[US EPA; Non-confidential Production Volume Information Submitted by Companies for Chemicals Under the 1986-2002 Inventory Update Rule (IUR). Oxirane,