Basic information
- CAS
2210-63-1- Standard SMILES
CCCCC1C(=O)NN(c2ccccc2)C1=O- InChIKey
REOJLIXKJWXUGB-UHFFFAOYSA-N- Molecular formula
- C13H16N2O2
- Average molar mass
- 232.28 g/mol
- Monoisotopic mass
- 232.12117776
Overview
Mofebutazone is a pyrazolidine that is phenylbutazone lacking one of the phenyl substituents. It is used for treatment of joint and muscular pain. It has a role as a non-steroidal anti-inflammatory drug and a non-narcotic analgesic.
Names & identifiers
- Preferred name
- Mofebutazone
- IUPAC
- 4-butyl-1-phenylpyrazolidine-3,5-dione
- English name
- MOFEBUTAZONE
- Molecular formula
- C13H16N2O2
- Molecular weight
- 232.28
Names & synonyms
Mofebutazone2210-63-14-butyl-1-phenylpyrazolidine-3,5-dioneMonophenylbutazoneMophebutazone2 FdbpMofebutazonaMofebutazonumMonazone4-Butyl-1-phenyl-3,5-pyrazolidinedione4-Butyl-1-phenyl-3,5-dioxopyrazolidineSPW36WUI5Z
Show more names
monobutyl2fdbpmonazanmobuzonreumatoxmobutazonmonorheumettenarcomonoltablets
2-Phenyl-3,5-dihydroxy-4-butylpyrazolidineNSC-73725DTXSID4023331CHEBI:762521-phenyl-4-n-butyl-3,5-dioxopyrazolidineRefChem:159305DTXCID203331M01AA02
Database identifiers
- CAS
2210-63-1- PubChem CID
- 16639
- DTXSID
DTXSID4023331- ChEMBL
CHEMBL1892201- ChEBI
CHEBI:76252- UNII
- SPW36WUI5Z
- EC Number
Properties
Computed structural properties
- XLogP
- 2.7
- Topological polar surface area
- 49.4 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 4
- Heavy atoms
- 17
- Formal charge
- 0
- Complexity
- 298
Physicochemical properties
- Melting point
- 102 · 102-103°
- Boiling point
- 374.44 °C · 374.44°C (rough estimate)
- Density
- 1.1099 · 1.1099 (rough estimate)
- refractive index
- 1.645 · 1.6450 (estimate)
- storage temp.
- Room Temperature
- solubility
- DMSO (Slightly), Methanol (Sparingly)
- form
- Solid
- pka
- 5.22 · 5.22±0.10(Predicted)
- color
- White to Off-White
- FDA UNII
- 36 WUI5Z · SPW36WUI5Z
- ATC code
- 1 AA02,M02AA02 · M01AA02,M02AA02
- Symbol(GHS)
- 6 · GHS06
- Signal word
- Danger
- Hazard statements
- 301 · H301-H315-H319-H332-H335
- Precautionary statements
- 261 · P261-P264-P270-P271-P280-P301+P310+P330-P302+P352+P312-P304+P340+P312-P305+P351+P338-P332+P313-P337+P313-P362-P403+P233-P405-P501
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 40 reports by companies from 1 notifications to the ECHA C&L Inventory.
Hazard information
Other Safety InformationIMAP assessments - 3,5-Pyrazolidinedione, 4-butyl-1-phenyl-: Environment tier I assessment
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Safety data
- Toxicity
- LD50 i.v. in mice: 600 mg/kg (Schoetensack)
- Signal word
- Danger
- Symbol(GHS)
- GHS06
- Hazard statements
- H301-H315-H319-H332-H335
- Precautionary statements
- P261-P264-P270-P271-P280-P301+P310+P330-P302+P352+P312-P304+P340+P312-P305+P351+P338-P332+P313-P337+P313-P362-P403+P233-P405-P501
Chemistry & industry
Pharmacology
ATC Code
M - Musculo-skeletal system
M - Musculo-skeletal system
QM - Musculo-skeletal system
QM - Musculo-skeletal system
MeSH Pharmacological Classification
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Applications
UsesMofebutazone is an anti-inflammatory drug used on the gastrointestinal and renal tissues.
Upstream & downstream products
Upstream raw materials
Suppliers33 total
阿诺西（上海）生物技术有限公司400-1107768 15058188853 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
Career Henan Chemica Co
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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