Basic information
- CAS
130065-61-1- Standard SMILES
CCCC1(CCC)CCC2(CCN(CCCN(CC)CC)C2)CC1.Cl.Cl- InChIKey
MOUZYBYTICOTFQ-UHFFFAOYSA-N- Molecular formula
- C22H46Cl2N2
- Average molar mass
- 409.5 g/mol
- Monoisotopic mass
- 408.3038049
Overview
Atiprimod Dihydrochloride is the dihydrochloride salt form of atiprimod, an orally bioavailable small molecule belonging to the azaspirane class of cationic amphiphilic agents with anti-inflammatory, antineoplastic, and anti-angiogenic activities. Atiprimod inhibits the phosphorylation of signal transducer and activator of transcription 3 (STAT3) and AKT, blocking the signaling pathways of interleukin-6, vascular endothelial growth factor (VEGF) and downregulating the anti-apoptotic proteins Bcl-2, Bcl-XL, and Mcl-1. This results in the inhibition of cell proliferation, induction of cell cycle arrest, and apoptosis.
Names & identifiers
- Preferred name
- Atiprimod Dihydrochloride
- IUPAC
- 3-(8,8-dipropyl-2-azaspiro[4.5]decan-2-yl)-N,N-diethylpropan-1-amine;dihydrochloride
- English name
- Azaspirane)
- Molecular formula
- C22H45ClN2
- Molecular weight
- 373.07
Names & synonyms
Atiprimod dihydrochloride130065-61-1Atiprimod HClSK&F 106615-A2Atiprimod dihydrochloride [USAN]SKF-106615-A2SK&F-106615-A2UNII-O12I24570RO12I24570RAtiprimod dihydrochloride (USAN)DTXSID201563312-(3-(Diethylamino)propyl)-8,8-dipropyl-2-azaspiro(4.5)decane dihydrochloride
Show more names
Atiprimod hydrochlorideAtiprimod dihydrochloride (SKF 106615N,N-Diethyl-8,8-dipropyl-2-azaspiro[4.5]decane-2-propanamine dihydrochloride
2-Azaspiro(4.5)decane-2-propanamine N,N-diethyl-8,8-dipropyl-, dihydrochloride2-[3-(Diethylamino)propyl]-8,8-dipropyl-2-azaspiro[4.5]decane dihydrochlorideRefChem:115427DTXCID5078822Atiprimod (hydrochloride)2-Azaspiro(4.5)decane-2-propanamine, N,N-diethyl-8,8-dipropyl-, dihydrochlorideN,N-Diethyl-8,8-dipropyl-2-azaspiro[4.5]decane-2-propanaminedihydrochlorideAtiprimod 2HCl
Database identifiers
- CAS
130065-61-1- PubChem CID
- 166556
- DTXSID
Properties
Computed structural properties
- Topological polar surface area
- 6.5 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 10
- Heavy atoms
- 26
- Formal charge
- 0
- Complexity
- 332
Physicochemical properties
- Melting point
- 251 · 251-253 °C
- storage temp.
- -20 °C · Store at -20°C
- solubility
- Soluble in DMSO
- FDA UNII
- 12 I24570R · O12I24570R
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302-H315-H319-H335
- Precautionary statements
- 280 · P280-P305+P351+P338
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P280-P305+P351+P338
Chemistry & industry
Applications
UsesAtiprimod Dihydrochloride is a JAK2 inhibitor and is also a novel immunomodulator.
Suppliers8 total
BOC Sciences16314854226; +8616314854226 · [email protected]
南通全益生物科技有限公司0513-66337626 18051384581 · [email protected]
上海陶术生物科技股份有限公司13564774135 · [email protected]
BOC Sciences[email protected]
上海宏叶生物科技有限公司400-9205774 400-920-5774 · [email protected]
TargetMol中国（陶术生物）4008200310 15002144251 · [email protected]
HANGZHOU CLAP TECHNOLOGY CO.,LTD86-571-88216897,88216896 13588875226 · [email protected]
南京世洲生物科技有限公司025-85560043 15850508050 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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