Pramipexole Dihydrochloride Monohydrate
Basic information
- CAS
191217-81-9- Standard SMILES
CCCN[C@H]1CCc2nc(N)sc2C1.Cl.Cl.O- InChIKey
APVQOOKHDZVJEX-QTPLPEIMSA-N- Molecular formula
- C10H21Cl2N3OS
- Average molar mass
- 302.3 g/mol
- Monoisotopic mass
- 301.0782389
Overview
Pramipexole hydrochloride is a hydrate that is the monohydrate of the dihydrochloride salt of pramiprexole. It has a role as an antiparkinson drug and a dopamine agonist. It contains a member of pramipexole hydrochloride anhydrous and a pramipexole(2+).
Names & identifiers
- Preferred name
- Pramipexole Dihydrochloride Monohydrate
- IUPAC
- (6S)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine;hydrate;dihydrochloride
- English name
- Pramipexole dihydrochloride monohydrate
- Molecular formula
- C10H20ClN3OS
- Molecular weight
- 265.8
Names & synonyms
191217-81-9Pramipexole dihydrochloride monohydrateDTXSID1044227RefChem:1113268Pramipexole 2HCl Monohydrate(S)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine dihydrochloride hydratePRAMIPEXOLE HYDROCHLORIDEBI-SifrolPramipexole hydrochloride hydrateMirapex (TN)OprymeaPramipexole HCl hydrate
Show more names
MirapexPramipexole for system suitability CRSPra-APIPramipexolePramipexole powderPPX dihydrochloridePramipexole monohydrate
UNII-3D867NP06Jpramipexole hydrate dihydrochloridePramipexole 2HCl hydrateMFCD02183927Pramipexole (dihydrochloride hydrate)C10H21Cl2N3OSHY-B0410ACCG-267486
Database identifiers
- CAS
191217-81-9- PubChem CID
- 166589
- DTXSID
DTXSID1044227- ChEMBL
CHEMBL3182733- ChEBI
CHEBI:51147- UNII
- 3D867NP06J
- EC Number
- 687-708-9
Properties
Computed structural properties
- Topological polar surface area
- 80.2 Ų
- Hydrogen bond donors
- 5
- Hydrogen bond acceptors
- 5
- Rotatable bonds
- 3
- Heavy atoms
- 17
- Formal charge
- 0
- Complexity
- 188
Experimental & physicochemical properties
Human Drugs
EMA approved medicines: Human medicine
EMA approved medicines: Human medicine
EMA approved medicines: Human medicine
Physicochemical properties
- Melting point
- 290 °C · 290 °C(dec.)
- storage temp.
- 2 · 2-8°C
- solubility
- Freely soluble in water, soluble in methanol, sparingly soluble or slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
- form
- Solid
- color
- White to Almost white
- optical activity
- Consistent with structure
- Merck
- 14 · 14,7705
- BCS Class
- 1 · 1
- Major Application
- pharmaceutical (small molecule)
- InChI
- InChI=1/C10H17N3S.ClH.H2O/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8;;/h7,12H,2-6H2,1H3,(H2,11,13);1H;1H2/t7-;;/s3
- InChIKey
- ZTZQAWQFTIVKMU-DCFBZVEJNA-N
- SMILES
- NC1SC2C[C@@H](NCCC)CCC=2N=1.Cl.O |&1:5,r|
- EWG's Food Scores
- 1 · 1
- FDA UNII
- 3 D867NP06J · 3D867NP06J
- NCI Drug Dictionary
- Mirapex
- UNSPSC Code
- 41116107 · 41116107
- NACRES
- 24 · NA.24
- Protein binding
- 20 % · <20%
- Excreted unchanged in urine
- 90 % · <90%
- Volume of distribution
- 400 · 400-500 Litres
- Biological half-life
- 8 · 8-14 / 36
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302-H336
- Precautionary statements
- 261 · P261-P264-P270-P271-P301+P312-P304+P340+P312
- WGK Germany
- 3 · 3
- RTECS
- 3375000 · DL3375000
- HS Code
- 2934200000 · 2934200000
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P203, P260, P261, P263, P264, P270, P271, P272, P273, P280, P301+P317, P302+P352, P304+P340, P317, P318, P319, P321, P330, P333+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 14 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Safety data
- wgk
- 3
- rtecs
- DL3375000
- hs_code
- 2934200000
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H302-H336
- Precautionary statements
- P261-P264-P270-P271-P301+P312-P304+P340+P312
Chemistry & industry
Applications
DescriptionPramipexole dihydrochloride monohydrate is an activator of D2DR, D3DR and D4DR. Pramipexole has been found to have neuroprotective effects independent of its dopamine receptor agonism. It reduces mitochondrial reactive oxygen species (ROS) production and inhibits the activation of apoptotic pathways.
UsesPramipexole is a drug used to treat the symptoms of Parkinson's Disease (PD) and a antidepressant. It is a non-ergot dopamine agonist drug that is efficacious in treating various Parkinson's symptoms such as tremor, rigidity, and bradykinesia (slow movement)
General DescriptionPramipexole Dihydrochloride is a non-ergot dopamine agonist widely used for the treatment of early and advanced Parkinson′s disease (PD). It is also used to treat restless legs syndrome.Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Additional notes
DefinitionChEBI: A hydrate that is the monohydrate of the dihydrochloride salt of pramiprexole.
Related reactions
0 records
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Compound notes
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