HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethylaluminum
TRIMETHYLALUMINUM · ATM · ALUMINUM TRIMETHYL · (CH3)3Al · trimethyl-aluminu · Trimethylaluminum solution · Trimethylaluminum, min. 98%, 93-1360, contained in 50 ml Swagelok cylinder for CVD/ALD · A-T mutated
Identifiers & Physical Properties
| CAS No. | 75-24-1 |
|---|---|
| Molecular formula | C3H9Al |
| Average molar mass | 72.09 g/mol |
| Monoisotopic mass | 72.05196392 g/mol |
| SMILES | [CH3][Al]([CH3])[CH3] |
| InChIKey | JLTRXTDYQLMHGR-UHFFFAOYSA-N |
| PubChem CID | 16682925 |
| EC No. | 200-853-0 |
| DTXSID | DTXSID9058787 |
Chemical & Physical Properties
| Topological polar surface area | 0 |
|---|---|
| Hydrogen bond donors | 0 |
| Hydrogen bond acceptors | 0 |
| Rotatable bonds | 0 |
| Heavy atoms | 4 |
| Formal charge | 0 |
| Complexity | 8 |
| Chemical classes | Metals -> Metals, Organic CompoundsFlammable agents - 3rd degree |
| Density | 0.752 @25 °C0.81 g/mL at 25 °C |
| Vapor pressure | 12.4 [mmHg]69.3 [mm Hg] @60 °C69.3 mmHg ( 60 °C) |
| Physical Description | LiquidCBIClear colorless liquidmp = 15 deg C[Merck Index] |
| Melting point | 15 °C |
| Boiling point | 126 °C |
| Flash point | 40 °F |
| Storage conditions | 0-6°C |
| Solubility | Soluble in aromatic, saturated aliphatic and cycloaliphatic hydrocarbons.REACTS |
| Physical state | Liquid |
| Color | Clear colorless |
| Specific gravity | 0.688 |
| Odor | Corrosive odor and "taste" may be detectable from trimethylaluminum fires |
| Specific heat capacity | Cp(liquid): 2.16 J/(g·K), at 25℃ |
| Sensitivity | Air & Moisture Sensitive |
| Hydrolytic Sensitivity | 9: reacts extremely rapidly with atmospheric moisture - may be pyrophoric - glove box or sealed system required |
| BRN | 3587197 |
| InChI | 1S/3CH3.Al/h3*1H3 |
| InChIKey | JLTRXTDYQLMHGR-UHFFFAOYSA-N |
| SMILES | C[Al](C)C |
| CAS DataBase Reference | 75-24-1(CAS DataBase Reference) |
| FDA UNII | AV210LG46J |
| NIST Chemistry Reference | Trimethylaluminum(75-24-1) |
| EPA Substance Registry System | Aluminum, trimethyl- (75-24-1) |
| UNSPSC Code | 12352103 |
| NACRES | NA.22 |
| GHS pictogram | GHS02,GHS05 |
| Signal word | Danger |
| GHS hazard statements | H250-H260-H314 |
| GHS precautionary statements | P210-P222-P231+P232-P233-P280-P223-P260-P264-P302+P334-P370+P378-P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P305+P351+P338-P402+P404-P405-P501 |
| Target organs | Central nervous system |
| Personal protective equipment (PPE) | Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter |
| Hazard symbols | F,C,N |
| Risk statements (R) | 11-14-17-34-50/53-65-67-14/15-63-48/20-51/53-20-62 |
| Safety statements (S) | 26-36/37/39-45-61-62-6A-43A-24/25-16-43-60-33-25-24 |
| UN transport number | UN 3399 4.3/PG 1 |
| Water hazard class (WGK) | 3 |
| RTECS number | BD2204000 |
| F | 1-10 |
| Autoignition temperature | Spontaneously ignites in air (even as a frozen solid) |
| TSCA inventory status | TSCA listed |
| Hazard class | 4.3Aquatic Chronic 3Asp. Tox. 1Eye Dam. 1Flam. Liq. 2Pyr. Liq. 1Repr. 2Skin Corr. 1BSTOT RE 2STOT SE 3Water-react 1 |
| Packing group | I |
| Customs code | 29319090 |
| Storage class | 4.2 - Pyrophoric and self-heating hazardous materials |
| Toxicity | TLV-TWA (ACGIH) 2 mg (Al)/m3 |
| REACH registrations | Active |
| Excepted quantities | Forbidden |
Safety & Regulations
| GHS classification | DangerH250 (98.9%): Catches fire spontaneously if exposed to air [Danger Pyrophoric liquids]P210, P222, P223, P231, P231+P232, P233, P260, P264, P264+P265, P280, P301+P330+P331, P302+P335+P334, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P363, P370+P378, P402+P404, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 350 reports by companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Regulatory information | Chemical: Aluminium, trimethyl-Aluminum, trimethyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Aluminum, trimethyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 04-01-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/11385Trimethylaluminum: HSNO Approval: HSR006351 Approved with controlsThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.) |
| Other safety information | IMAP assessments - Aluminium, trimethyl-: Human health tier I assessment |
| Hazards summary | Pyrophoric and corrosiveReacts violently with water[Merck Index] PyrophoricReacts violently with water evolving flammable gasesCauses burnsInhalation may cause corrosive injuries to upper respiratory tract[Sigma-Aldrich MSDS] See Triethylaluminum. |
| Hazard Classes and Categories | Pyr. Liq. 1 (98.9%)Flammable agents - 3rd degree, Reactive agents - 3rd degree |
| CSL Reaction Information | CSL00130TETRAFLUORO-1,4-BENZOQUINONE + TRIMETHYLALUMINUMChemical & Engineering News (20 May 1996) Vol. 74, No. 21, pp. 4. Aluminum compounds with perfluorophenol substituents have been identified as potentially explosive [Organometallics, 10, 1917 (1991)]. I wish to communicate my experience as well as that of my colleagues. Adding 1,4-tetrafluorodihydroquinone (1 mol equivalent) in toluene to a toluene solution of trimethyl aluminum (1.1 mol equivalents) resulted in a gel-like reaction mixture. Filtration and drying gave a white solid that was isolated in a nitrogen-filled glove box. A 50-mg sample of this solid detonated violently when pressed gently between a stainless-steel spatula and a glass surface. Fortunately, no one was hurt in this incident. Tris(pentafluorophenyl)aluminum etherate has been reported to be explosive when heated [Naturforschg., 20b, 5 (1965)]. Clearly, extreme caution should be used when handling compounds of aluminum with fluorinated ligands.Aluminum complexes with fluorinated ligandsNot Available |
| Minimum Risk Level | Intermediate Oral: 1.0 mg/kg/day (L134) Chronic Oral: 1.0 mg/kg/day (L134) |
| Protective Action Criteria (PAC) | 11 [mg/m3]120 [mg/m3]710 [mg/m3] |
| Health effects | Aluminum targets the nervous system and causes decreased nervous system performance and is associated with altered function of the blood-brain barrier. The accumulation of aluminum in the body may cause bone or brain diseases. High levels of aluminum have been linked to Alzheimer's disease. A small percentage of people are allergic to aluminium and experience contact dermatitis, digestive disorders, vomiting or other symptoms upon contact or ingestion of products containing aluminium. (L739, L740) |
| Adverse effects | Dermatotoxin - Skin burns. |
| Exposure routes | Oral (L739)inhalation (L739) |
| Toxicity summary | The main target organs of aluminum are the central nervous system and bone. Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphorus. The decreased phosphate body burden results in osteomalacia (softening of the bones due to defective bone mineralization) and rickets. Aluminum's neurotoxicity is believed to involve several mechanisms. Changes in cytoskeletal protein functions as a results of altered phosphorylation, proteolysis, transport, and synthesis are believed to be one cause. Aluminum may induce neurobehavioral effects by affecting permeability of the blood-brain barrier, cholinergic activity, signal transduction pathways, lipid peroxidation, and impair neuronal glutamate nitric oxide-cyclic GMP pathway, as well as interfere with metabolism of essential trace elements because of similar coordination chemistries and consequent competitive interactions. It has been suggested that aluminum's interaction with estrogen receptors increases the expression of estrogen-related genes and thereby contributes to the progression of breast cancer (A235), but studies have not been able to establish a clear link between aluminum and increased risk of breast cancer (A15468). Certain aluminum salts induce immune responses by activating inflammasomes. (L739, A235, A236) |
| Signs and Symptoms | Inhalating aluminum dust causes coughing and abnormal chest X-rays. A small percentage of people are allergic to aluminium and experience contact dermatitis, digestive disorders, vomiting or other symptoms upon contact or ingestion of products containing aluminium. (L739, L740) |
| Carcinogen Classification | Not listed by IARC. IARC classified aluminum production as carcinogenic to humans (Group 1), but did not implicate aluminum itself as a human carcinogen. (L135) A link between use of aluminum-containing antiperspirants and increased risk of breast cancer has been proposed (A235), but studies have not been able to establish a clear link (A15468). |
| F | 1-10 |
| Personal protective equipment (PPE) | Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter |
| Water hazard class (WGK) | 3 |
| TSCA inventory status | TSCA listed |
| RTECS number | BD2204000 |
| UN transport number | UN 3399 4.3/PG 1 |
| Customs code | 29319090 |
| Toxicity | TLV-TWA (ACGIH) 2 mg (Al)/m3 |
| Risk statements (R) | 11-14-17-34-50/53-65-67-14/15-63-48/20-51/53-20-62 |
| Signal word | Danger |
| GHS pictogram | GHS02,GHS05 |
| Hazard symbols | F,C,N |
| Safety statements (S) | 26-36/37/39-45-61-62-6A-43A-24/25-16-43-60-33-25-24 |
| Hazard class | 4.3Aquatic Chronic 3Asp. Tox. 1Eye Dam. 1Flam. Liq. 2Pyr. Liq. 1Repr. 2Skin Corr. 1BSTOT RE 2STOT SE 3Water-react 1 |
| Storage class | 4.2 - Pyrophoric and self-heating hazardous materials |
| Packing group | I |
| Target organs | Central nervous system |
| GHS hazard statements | H250-H260-H314 |
| Excepted quantities | Forbidden |
| REACH registrations | Active |
| Autoignition temperature | Spontaneously ignites in air (even as a frozen solid) |
| GHS precautionary statements | P210-P222-P231+P232-P233-P280-P223-P260-P264-P302+P334-P370+P378-P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P305+P351+P338-P402+P404-P405-P501 |
Applications & Uses
Uses
Trimethyl aluminum is a highly reactivereducing and alkylating agent. It is used in aZiegler-Natta catalyst for polymerization andhydrogenation.
Uses
Trimethylaluminum can be used in the pretreatment of Al2O3/p-type GaSb capacitors.
Uses
Trimethylaluminium can be used as catalyst for olefin polymerization, pyrophoric fuel, manufacture of straight-chain primary alcohols and olefins, to produce luminous trails in upper atmosphere to track rockets.