Basic information
- CAS
2574-78-9- Standard SMILES
NC(=O)c1[nH]cnc1N.O=C(O)c1cc(=O)[nH]c(=O)[nH]1- InChIKey
PVCSUEOGEIOUHG-UHFFFAOYSA-N- Molecular formula
- C9H10N6O5
- Average molar mass
- 282.21 g/mol
- Monoisotopic mass
- 282.07126744
Overview
RN given refers to parent cpd
Names & identifiers
- Preferred name
- Orazamide
- IUPAC
- 4-amino-1H-imidazole-5-carboxamide;2,4-dioxo-1H-pyrimidine-6-carboxylic acid
- English name
- Orazamide
- Molecular formula
- C9H10N6O5
- Molecular weight
- 282.21
Names & synonyms
OrazamideCLY9MRR8FV5-aminoimidazole-4-carboxamide orotateAICA orotateRefChem:1684151,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylic acid cpd with 5-amino-1H-imidazole-4-carboxamide219-923-74(5)-aminoimidazole-5(4)-carboxamide orotic acid salt60104-30-5AicaminAicamineorazamid
Show more names
QrazamideaicamindihydrateaicoratdihydrateOrazamide orotateorazamidedihydrateOrazamide USP/EP/BPaicaorotatedihydrate5-Aminoimedazole-4-carboxamideorotate
OrazamidaOrazamidum2574-78-9Orazamide [INN]4-amino-1H-imidazole-5-carboxamide;2,4-dioxo-1H-pyrimidine-6-carboxylic acid1,2,3,6-Tetrahydro-2,6-dioxopyrimidine-4-carboxylic acid, compoundwith 5-amino-1H-imidazole-4-carboxamide (1:1) dihydrate7425-69-6Aicamin dihydrate
Database identifiers
- CAS
2574-78-9、60104-30-5、7425-69-6
Properties
Computed structural properties
- Topological polar surface area
- 193 Ų
- Hydrogen bond donors
- 6
- Hydrogen bond acceptors
- 7
- Rotatable bonds
- 2
- Heavy atoms
- 20
- Formal charge
- 0
- Complexity
- 393
Physicochemical properties
- Melting point
- 284 · 284-285 °C (decomp)
- InChI
- InChI=1S/C5H4N2O4.C4H6N4O.2H2O/c8-3-1-2(4(9)10)6-5(11)7-3;5-3-2(4(6)9)7-1-8-3;;/h1H,(H,9,10)(H2,6,7,8,11);1H,5H2,(H2,6,9)(H,7,8);2*1H2
- InChIKey
- RAZMBRTXTADRMQ-UHFFFAOYSA-N
- SMILES
- C1(C(=O)O)NC(NC(=O)C=1)=O.C1(C(=O)N)NC=NC=1N.O.O
- CAS DataBase Reference
- 2574 · 2574-78-9(CAS DataBase Reference)
- FDA UNII
- 9 MRR8FV · CLY9MRR8FV
Chemistry & industry
Applications
UsesOrazamide is an AICA orotate. Orazamide can prevent anti-TB drug-induced liver damage by downregulating the protein expression of HMGB 1 and RAGE in liver tissue and inhibiting the secretion of inflammatory factors. Orazamide can be used in research on hepatitis and liver cirrhosis[1].
Upstream & downstream products
Upstream raw materials
Suppliers24 total
Hebei Chuanghai Biotechnology Co., Ltd+86-17732866630 · [email protected]
武汉敬康恩生物医药科技有限公司13720134139 086-15871494362 13720134139 · [email protected]
LGM Pharma1-(800)-881-8210 · [email protected]
湖北威德利化学试剂有限公司17771473825 13385289472 · [email protected]
欧利希（湖北）医药科技有限公司17316404525 17316404525 · [email protected]
NANJING YINGWEN BIOTECHNOLOGY CO LTD+8613382787392 · [email protected]
贵州迪大科技有限责任公司0851-8475-2296 18096062265 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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