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Basic information
- CAS
475-81-0- Standard SMILES
COc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3- InChIKey
RUZIUYOSRDWYQF-HNNXBMFYSA-N- Molecular formula
- C21H25NO4
- Average molar mass
- 355.4 g/mol
- Monoisotopic mass
- 355.17835828
Names & identifiers
- Preferred name
- (+)-Glaucine
- IUPAC
- (6aS)-1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline
- English name
- Boldine dimethyl ether
- Molecular formula
- C21H25NO4
- Molecular weight
- 355.43
Names & synonyms
Glaucine475-81-0Bromcholitin(+)-Glaucine(6aS)-1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolineNU19306XA7NSC-34396(6aS)-1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo(de,g)quinolineRefChem:4080575,6,6a,7-Tetrahydro-1,2,9,10-tetramethoxy-6-methyl-4H-dibenzo(de,g)quinolined-GlaucineBoldine dimethyl ether
Show more names
Aids011385Aids-011385(S)-Glaucine
GlauventS-(+)-GlaucineGlaucine fumarate1,2,9,10-tetramethoxyaporphine1,2,9,10-Tetramethoxy-6a-alpha-aporphineNSC34396CHEMBL228082NSC 34396
Database identifiers
- CAS
475-81-0- PubChem CID
- 16754
- DTXSID
DTXSID8031100- ChEMBL
CHEMBL1788155、CHEMBL228082- ChEBI
CHEBI:5373- UNII
- NU19306XA7
Properties
Computed structural propertiesFilling in
- XLogP
- 3.4
- Topological polar surface area
- 40.2 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 5
- Rotatable bonds
- 4
- Heavy atoms
- 26
- Formal charge
- 0
- Complexity
- 489
Physicochemical properties
- Melting point
- 246 · 246-247℃
- alpha
- 20 · D20 +115° (c = 3 in alc)
- Boiling point
- 488.45 °C · 488.45°C (rough estimate)
- Density
- 1.166 · 1.166±0.06 g/cm3 (20 ºC 760 Torr)
- refractive index
- 1.5614 · 1.5614 (estimate)
- storage temp.
- -20 °C · -20°C Freezer, Under inert atmosphere
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 6.35 · 6.35±0.20(Predicted)
- color
- Pale Beige
- Cosmetics Ingredients Functions
- SKIN CONDITIONING
- EWG's Food Scores
- 1 · 1
- FDA UNII
- 19306 XA7 · NU19306XA7
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]；H315 (97.4%): Causes skin irritation [Warning Skin corrosion/irritation]；H319 (97.4%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H335 (97.4%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 39 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
Hazard information
Hazard Classes and CategoriesAcute Tox. 4 (100%)；Skin Irrit. 2 (97.4%)；Eye Irrit. 2 (97.4%)；STOT SE 3 (97.4%)
Safety data
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H302-H319-H315-H335
- Precautionary statements
- P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues.
Agents that suppress cough. They act centrally on the medullary cough center. EXPECTORANTS, also used in the treatment of cough, act locally.
Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS.
Applications
DescriptionGlaucine (Item No. 17338) is an analytical reference standard categorized as an antitussive. Glaucine has hallucinogenic properties. This product is intended for research and forensic applications.
Usesd-Glaucine has bronchodilator and antiinflammatory effects, acting as a PDE4 inhibitor and calcium channel blocker, and is used medically as an antitussive in some countries.
Upstream & downstream products
Downstream products
Suppliers74 total
南京世洲生物科技有限公司025-85560043 15850508050 · [email protected]
銘瑞集團有限公司17318633522 · [email protected]
艾吉析科技（上海）有限公司17717235263 · [email protected]
成都埃法生物科技有限公司028-028-85142057 19983342022 · [email protected]
上海麦克林生化科技股份有限公司
Related reactions
1 records
Compound notes
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