Nile Blue hydrochloride
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Basic information
- CAS
2381-85-3- Standard SMILES
CC[N+](CC)=c1ccc2nc3c(cc(N)c4ccccc43)oc-2c1.[Cl-]- InChIKey
XJCPMUIIBDVFDM-UHFFFAOYSA-M- Molecular formula
- C20H20ClN3O
- Average molar mass
- 353.8 g/mol
- Monoisotopic mass
- 353.12949
Overview
Nile blue A is an organic chloride salt having 5-amino-9-(diethylamino)benzo[a]phenoxazin-7-ium as the couterion. fluorescent dye which is also a potent photosensitiser for photodynamic therapy. It has a role as a fluorochrome and a histological dye. It contains a nile blue(1+).
Names & identifiers
- Preferred name
- Nile Blue hydrochloride
- IUPAC
- (5-aminobenzo[a]phenoxazin-9-ylidene)-diethylazanium chloride
- English name
- NILE BLUE CHLORIDE
- Molecular formula
- C20H20N3O.Cl
- Molecular weight
- 353.85
Names & synonyms
Nile Blue hydrochlorideRefChem:1092420Nile Blue chloride2381-85-3Basic Blue 12Nile Blue ANile blueCresol Fast VioletNile Blue AXC.I. Basic Blue 12NILEBLUECHLORIDENile Blue Base
Show more names
CI 51180nileblueaxCI NO 51180Nile Blue BXnilebluebasec.i.basicblue12cresolfastvioletBlue Nile chloride
C.I. 511805-amino-9-(diethylamino)benzo[a]phenoxazin-7-ium chlorideNSC 1461845-Amino-9-(diethylamino)benzo(a)phenoxazin-7-ium chlorideBenzo[a]phenoxazin-7-ium, 5-amino-9-(diethylamino)-, chlorideUNII-E58RL8T2X3E58RL8T2X35H-Benzo(a)phenazoxazine, 9-diethylamino-5-imino-, hydrochloride
Database identifiers
- CAS
2381-85-3- PubChem CID
- 16938
- DTXSID
DTXSID40883834- ChEMBL
CHEMBL407862
Properties
Computed structural propertiesFilling in
- Topological polar surface area
- 50.6 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 2
- Heavy atoms
- 25
- Formal charge
- 0
- Complexity
- 625
Physicochemical properties
- Melting point
- 250 °C · >250°C
- storage temp.
- room temp
- solubility
- Solubility Soluble in water, ethanol
- pka
- 9.7 · 9.7(at 25℃)
- Colour Index
- 51180 · 51180
- form
- Powder
- color
- Dark blue
- PH Range
- Blue (9.4) to purple-red (11.0)
- Water Solubility
- 1 mg/mL, · water: 1mg/mL, opaque, blue to very deep blue
- λmax
- 638 nm · 638nm
- BRN
- 3923952 · 3923952
- Stability
- Stable. Incompatible with strong oxidizing agents.
- Major Application
- CMOS technology, waveguides, electroluminescent device, inks, plastics, biofuel cells, detect bacterial growth, lipids, DNA, diagnosis of diseases related to amyloid accumulation, fluorescent probes, therapy of viral diseases, photodynamic therapy
- FDA UNII
- 58 RL8T2X3 · E58RL8T2X3
- EPA Substance Registry System
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- wgk
- 3
- tsca
- TSCA listed
- rtecs
- DJ1930000
- hs_code
- 32041990
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- safety_code
- 22-24/25
- Hazard statements
- H315-H319
- Precautionary statements
- P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Chemistry & industry
Applications
UsesNile Blue chloride is a histological and lipid stain.
UsesNile Blue A 37 is used in microscopy, immunoassays, and in laser technology. It is also suitable for the prevention of deposits during the polymerization of vinyl chloride homo-, co-, and graft polymers.
Preparation methods
Preparationcommonly known as the Nile Blue. 5-(Diethylamino)-2-nitrosophenoland Naphthalen-1-amine hydrochloride reaction.
Additional notes
DefinitionChEBI: An organic chloride salt having 5-amino-9-(diethylamino)benzo[a]phenoxazin-7-ium as the couterion. fluorescent dye which is also a potent photosensitiser for photodynamic therapy.
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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