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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 17153Generated: October 24, 2026

3,5-Dichloropyridine

NSC 60546 · 3,5-CHLOROPYRIDINE · 3,5-dichloro-pyridin · 3.5-Dichloropryidine · 3,5-Dichloripyridine · Dichloropyridine,98% · 3,5-DICHLOROPYRIDINE · 3,5-Dichloroypyridine

https://huagongshe.com/en/chemical/17153

3,5-Dichloropyridine molecular structure

Identifiers & Physical Properties

CAS No.2457-47-8
Molecular formulaC5H3Cl2N
Average molar mass147.99 g/mol
Monoisotopic mass146.96425446 g/mol
SMILESClc1cncc(Cl)c1
InChIKeyWPGHPGAUFIJVJF-UHFFFAOYSA-N
PubChem CID17153
EC No.219-537-9
DTXSIDDTXSID60179307

Chemical & Physical Properties

XLogP2.6
Topological polar surface area12.9
Hydrogen bond donors0
Hydrogen bond acceptors1
Rotatable bonds0
Heavy atoms8
Formal charge0
Complexity68.8
Chemical classesNitrogen Compounds -> Pyridines
SpringerMaterials PropertiesNuclear quadrupole resonance spectroscopy
Vapor pressure0.77 [mmHg]
Physical DescriptionWhite crystalline powder with an unpleasant odor[Alfa Aesar MSDS]
Melting point65-67 °C (lit.)
Boiling point178 °C
Density1.39
Flash point>110°C
Storage conditionsInert atmosphere,Room Temperature
SolubilityChloroform, Ethyl Acetate
Physical stateSolid
pKa (acidity coefficient)0.32±0.10(Predicted)
ColorWhite to Off-White
BRN1973
InChIInChI=1S/C5H3Cl2N/c6-4-1-5(7)3-8-2-4/h1-3H
InChIKeyWPGHPGAUFIJVJF-UHFFFAOYSA-N
SMILESC1=NC=C(Cl)C=C1Cl
CAS DataBase Reference2457-47-8(CAS DataBase Reference)
FDA UNIID9K92ASQ4D
NIST Chemistry ReferencePyridine, 3,5-dichloro-(2457-47-8)
UNSPSC Code12352100
NACRESNA.22
GHS pictogramGHS05,GHS07
Signal wordDanger
GHS hazard statementsH302-H315-H318-H335
GHS precautionary statementsP280-P301+P312+P330-P302+P352-P305+P351+P338+P310
Target organsRespiratory system
Personal protective equipment (PPE)dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard symbolsXn,Xi
Risk statements (R)22-37/38-41-36/37/38
Safety statements (S)26-39-36
UN transport numberUN2811
Water hazard class (WGK)3
RTECS numberUS8575000
Hazard NoteIrritant
Hazard class6.1Acute Tox. 4 OralEye Dam. 1Skin Irrit. 2STOT SE 3
Customs code29333990
Storage class11 - Combustible Solids

Safety & Regulations

GHS classificationDangerH302 (97.8%): Harmful if swallowed [Warning Acute toxicity, oral]P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 45 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazards summaryCauses somnolence and fatty liver degeneration in intraperitoneal lethal-dose studies of mice (LD50 = 1,180 mg/kg)[RTECS] A skin and strong eye irritantHarmful by ingestion and skin absorption[Alfa Aesar MSDS] See 3-Chloropyridine.
Hazard Classes and CategoriesAcute Tox. 4 (97.8%)
Adverse effectsNeurotoxin - Other CNS neurotoxin
Personal protective equipment (PPE)dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Water hazard class (WGK)3
RTECS numberUS8575000
UN transport numberUN2811
Customs code29333990
Risk statements (R)22-37/38-41-36/37/38
Signal wordDanger
GHS pictogramGHS05,GHS07
Hazard symbolsXn,Xi
hazard_noteIrritant
Safety statements (S)26-39-36
Hazard class6.1Acute Tox. 4 OralEye Dam. 1Skin Irrit. 2STOT SE 3
Storage class11 - Combustible Solids
Target organsRespiratory system
GHS hazard statementsH302-H315-H318-H335
GHS precautionary statementsP280-P301+P312+P330-P302+P352-P305+P351+P338+P310

Applications & Uses

Uses

3,5-Dichloropyridine (cas# 2457-47-8) is a compound useful in organic synthesis.