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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 1742Generated: October 23, 2026

4-Hydroxybenzoic acid hydrazide

4-HYDROXYBENZOHYDRAZIDE · PAHBAH · DK841 · NSC647 · NSC 647 · ST5046190 · 4OHPhCON2 · AIDS009023

https://huagongshe.com/en/chemical/1742

4-Hydroxybenzoic acid hydrazide molecular structure

Identifiers & Physical Properties

CAS No.5351-23-5
Molecular formulaC7H8N2O2
Average molar mass152.15 g/mol
Monoisotopic mass152.0585775 g/mol
SMILESNNC(=O)c1ccc(O)cc1
InChIKeyZMZGIVVRBMFZSG-UHFFFAOYSA-N
PubChem CID1742
ChEMBLCHEMBL124267
ChEBICHEBI:195425
EC No.226-326-5
DTXSIDDTXSID90201721

Chemical & Physical Properties

XLogP-0.3
Topological polar surface area75.4
Hydrogen bond donors3
Hydrogen bond acceptors3
Rotatable bonds1
Heavy atoms11
Formal charge0
Complexity141
LogP (partition coefficient)-0.33
Solubility22.4 [ug/mL] (The mean of the results at pH 7.4)26.5g/l
Endocrine DisruptorsPotential endocrine disrupting compound
Melting point264-266 °C (dec.)(lit.)
Boiling point274.61°C (rough estimate)
Density1.2804 (rough estimate)
Refractive index1.5200 (estimate)
Storage conditionsStore at +15°C to +25°C.
Physical stateFine Crystalline Powder
pKa (acidity coefficient)8.57±0.15(Predicted)
ColorWhite to slightly beige
Biological sourcesynthetic
λmax245nm(MeOH)(lit.)
BRN473052
InChI1S/C7H8N2O2/c8-9-7(11)5-1-3-6(10)4-2-5/h1-4,10H,8H2,(H,9,11)
InChIKeyZMZGIVVRBMFZSG-UHFFFAOYSA-N
SMILESNNC(=O)c1ccc(O)cc1
CAS DataBase Reference5351-23-5(CAS DataBase Reference)
FDA UNIIY4G7G6U5GQ
NIST Chemistry ReferenceP-hydroxybenzoic acid, hydrazide(5351-23-5)
UNSPSC Code12352204
NACRESNA.32
GHS pictogramGHS07
Signal wordWarning
GHS hazard statementsH315-H319-H335
GHS precautionary statementsP261-P264-P271-P280-P302+P352-P305+P351+P338
Target organsRespiratory system
Personal protective equipment (PPE)dust mask type N95 (US), Eyeshields, Gloves
Hazard symbolsXi,C
Risk statements (R)36/37/38
Safety statements (S)26-36-37/39
Water hazard class (WGK)3
Hazard classIRRITANTEye Irrit. 2Skin Irrit. 2STOT SE 3
Customs code29280090
Storage class11 - Combustible Solids
REACH registrationsActive

Safety & Regulations

GHS classificationWarningH315 (98%): Causes skin irritation [Warning Skin corrosion/irritation]P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 49 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Regulatory informationStatus: Active Update: 08-03-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/22867Benzoic acid, 4-hydroxy-, hydrazide: Does not have an individual approval but may be used under an appropriate group standard
Hazard Classes and CategoriesSkin Irrit. 2 (98%)
Personal protective equipment (PPE)dust mask type N95 (US), Eyeshields, Gloves
Water hazard class (WGK)3
Customs code29280090
Risk statements (R)36/37/38
Signal wordWarning
GHS pictogramGHS07
Hazard symbolsXi,C
Safety statements (S)26-36-37/39
Hazard classIRRITANTEye Irrit. 2Skin Irrit. 2STOT SE 3
Storage class11 - Combustible Solids
Target organsRespiratory system
GHS hazard statementsH315-H319-H335
REACH registrationsActive
GHS precautionary statementsP261-P264-P271-P280-P302+P352-P305+P351+P338

Applications & Uses

Uses

4-Hydroxybenzhydrazide is a reagent for the rapid automated determination of serum glucose.It can be used as an indicator for the determination of carbohydrates. The acid-hydrolyzable side chains of tissue (liver) bound 4-Hydroxybenzhydrazide can be used as markers to monitor its residues in chickens.

Uses

4-Hydroxybenzhydrazide has been used:for determining the concentration of maltose from starch digestionfor analysis of sugars from fructan containing food hydrolysatein colorimetric assay for reducing sugar estimation from processed feedstuff