4-Hydroxybenzoic acid hydrazide

HCID 1742CAS 5351-23-5
Substructure searchFind similar structures

Basic information

Standard SMILES
NNC(=O)c1ccc(O)cc1
InChIKey
ZMZGIVVRBMFZSG-UHFFFAOYSA-N
Molecular formula
C7H8N2O2
Average molar mass
152.15 g/mol
Monoisotopic mass
152.0585775

Overview

4-hydroxybenzohydrazide is a carbohydrazide obtained by formal condensation of the carboxy group of 4-hydroxybenzoic acid with hydrazine. It is a member of phenols and a carbohydrazide. It is functionally related to a 4-hydroxybenzoic acid.

Names & identifiers

Preferred name
4-Hydroxybenzoic acid hydrazide
IUPAC
4-hydroxybenzohydrazide
English name
4-Hydroxybenzhydrazide
Molecular formula
C7H8N2O2
Molecular weight
152.15

Names & synonyms

4-hydroxybenzhydrazide4-Hydroxybenzohydrazide5351-23-54-Hydroxybenzoic acid hydrazide4-Hydroxybenzoylhydrazinep-Hydroxybenzoic acid hydrazideY4G7G6U5GQpara-Hydroxybenzoic acid hydrazideNSC-647DTXSID90201721RefChem:524006DTXCID20124212
Show more names
PAHBAHDK841NSC647NSC 647ST50461904OHPhCON2AIDS009023EU-0100568(4-Hydroxyb
226-326-54-Hydroxybenzoic hydrazidep-HydroxybenzhydrazideBenzoic acid, 4-hydroxy-, hydrazide(p-Hydroxybenzoyl)hydrazinep-Hydroxybenzoic hydrazideMFCD000076054-Oxidanylbenzohydrazide

Database identifiers

CAS
5351-23-5
PubChem CID
1742
DTXSID
DTXSID90201721
ChEMBL
CHEMBL124267
ChEBI
CHEBI:195425
UNII
Y4G7G6U5GQ
EC Number
226-326-5
Nikkaji
J5.203E

Properties

Computed structural properties

XLogP
-0.3
Topological polar surface area
75.4 Ų
Hydrogen bond donors
3
Hydrogen bond acceptors
3
Rotatable bonds
1
Heavy atoms
11

Experimental & physicochemical properties

LogP-0.33
Solubility22.4 [ug/mL] (The mean of the results at pH 7.4)
Endocrine DisruptorsPotential endocrine disrupting compound

Physicochemical properties

Melting point
264 · 264-266 °C (dec.)(lit.)
Boiling point
274.61 °C · 274.61°C (rough estimate)
Density
1.2804 · 1.2804 (rough estimate)
refractive index
1.52 · 1.5200 (estimate)
storage temp.
15 °C · Store at +15°C to +25°C.
solubility
26.5 g/l · 26.5g/l

Safety & regulation

GHS classification

GHS Classification · 4 items

Warning

H315 (98%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 49 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Regulatory Information · 2 items

Status: Active Update: 08-03-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/22867

Benzoic acid, 4-hydroxy-, hydrazide: Does not have an individual approval but may be used under an appropriate group standard

Hazard Classes and CategoriesSkin Irrit. 2 (98%)

Safety data

PPE
dust mask type N95 (US), Eyeshields, Gloves
wgk
3
hs_code
29280090
risk_code
36/37/38
Signal word
Warning
Symbol(GHS)
GHS07

Chemistry & industry

Applications · 2 items

Uses4-Hydroxybenzhydrazide is a reagent for the rapid automated determination of serum glucose.It can be used as an indicator for the determination of carbohydrates. The acid-hydrolyzable side chains of tissue (liver) bound 4-Hydroxybenzhydrazide can be used as markers to monitor its residues in chickens.

Uses4-Hydroxybenzhydrazide has been used:for determining the concentration of maltose from starch digestionfor analysis of sugars from fructan containing food hydrolysatein colorimetric assay for reducing sugar estimation from processed feedstuff

Upstream & downstream products

Suppliers50 total

国药集团化学试剂有限公司86-21-63210123 · [email protected]
常州帝通化工有限公司+86-0519-88298848 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
武汉欣扬瑞和化学科技有限公司153-07155313 15307155313 · [email protected]
温州共赢化学有限公司+86-0086-577-64498589 +86-15355981851 · [email protected]

Related reactions

112 records
New reaction record

Linked notes

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