4-Hydroxybenzoic acid hydrazide
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Basic information
- CAS
5351-23-5- Standard SMILES
NNC(=O)c1ccc(O)cc1- InChIKey
ZMZGIVVRBMFZSG-UHFFFAOYSA-N- Molecular formula
- C7H8N2O2
- Average molar mass
- 152.15 g/mol
- Monoisotopic mass
- 152.0585775
Overview
4-hydroxybenzohydrazide is a carbohydrazide obtained by formal condensation of the carboxy group of 4-hydroxybenzoic acid with hydrazine. It is a member of phenols and a carbohydrazide. It is functionally related to a 4-hydroxybenzoic acid.
Names & identifiers
- Preferred name
- 4-Hydroxybenzoic acid hydrazide
- IUPAC
- 4-hydroxybenzohydrazide
- English name
- 4-Hydroxybenzhydrazide
- Molecular formula
- C7H8N2O2
- Molecular weight
- 152.15
Names & synonyms
4-hydroxybenzhydrazide4-Hydroxybenzohydrazide5351-23-54-Hydroxybenzoic acid hydrazide4-Hydroxybenzoylhydrazinep-Hydroxybenzoic acid hydrazideY4G7G6U5GQpara-Hydroxybenzoic acid hydrazideNSC-647DTXSID90201721RefChem:524006DTXCID20124212
Show more names
PAHBAHDK841NSC647NSC 647ST50461904OHPhCON2AIDS009023EU-0100568(4-Hydroxyb
226-326-54-Hydroxybenzoic hydrazidep-HydroxybenzhydrazideBenzoic acid, 4-hydroxy-, hydrazide(p-Hydroxybenzoyl)hydrazinep-Hydroxybenzoic hydrazideMFCD000076054-Oxidanylbenzohydrazide
Database identifiers
- CAS
5351-23-5- PubChem CID
- 1742
- DTXSID
DTXSID90201721- ChEMBL
CHEMBL124267- ChEBI
CHEBI:195425
Properties
Computed structural propertiesFilling in
- XLogP
- -0.3
- Topological polar surface area
- 75.4 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 1
- Heavy atoms
- 11
- Formal charge
- 0
- Complexity
- 141
Experimental & physicochemical properties
LogP-0.33
Solubility22.4 [ug/mL] (The mean of the results at pH 7.4)
Endocrine DisruptorsPotential endocrine disrupting compound
Physicochemical properties
- Melting point
- 264 · 264-266 °C (dec.)(lit.)
- Boiling point
- 274.61 °C · 274.61°C (rough estimate)
- Density
- 1.2804 · 1.2804 (rough estimate)
- refractive index
- 1.52 · 1.5200 (estimate)
- storage temp.
- 15 °C · Store at +15°C to +25°C.
- solubility
- 26.5 g/l · 26.5g/l
- form
- Fine Crystalline Powder
- pka
- 8.57 · 8.57±0.15(Predicted)
- color
- White to slightly beige
- biological source
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H315 (98%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 49 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory Information
Status: Active Update: 08-03-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/22867
Benzoic acid, 4-hydroxy-, hydrazide: Does not have an individual approval but may be used under an appropriate group standard
Hazard Classes and CategoriesSkin Irrit. 2 (98%)
Safety data
- PPE
- dust mask type N95 (US), Eyeshields, Gloves
- wgk
- 3
- hs_code
- 29280090
- risk_code
- 36/37/38
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- Xi,C
- safety_code
- 26-36-37/39
- hazard_class
- IRRITANT
- Storage Class
- 11 - Combustible Solids
- target organs
- Respiratory system
Chemistry & industry
Applications
Uses4-Hydroxybenzhydrazide is a reagent for the rapid automated determination of serum glucose.It can be used as an indicator for the determination of carbohydrates. The acid-hydrolyzable side chains of tissue (liver) bound 4-Hydroxybenzhydrazide can be used as markers to monitor its residues in chickens.
Uses4-Hydroxybenzhydrazide has been used:for determining the concentration of maltose from starch digestionfor analysis of sugars from fructan containing food hydrolysatein colorimetric assay for reducing sugar estimation from processed feedstuff
Upstream & downstream products
Upstream raw materials
Downstream products
Related reactions
112 records
Compound notes
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