Hexaethylene Glycol

HCID 17472CAS 2615-15-8
Substructure searchFind similar structures

Basic information

Standard SMILES
OCCOCCOCCOCCOCCOCCO
InChIKey
IIRDTKBZINWQAW-UHFFFAOYSA-N
Molecular formula
C12H26O7
Average molar mass
282.33 g/mol
Monoisotopic mass
282.16785317

Overview

Hexaethylene glycol is a poly(ethylene glycol).

Names & identifiers

Preferred name
Hexaethylene Glycol
IUPAC
2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanol
English name
Hexaethylene glycol
Molecular formula
C12H26O7
Molecular weight
282.33

Names & synonyms

HEXAETHYLENE GLYCOL2615-15-83,6,9,12,15-Pentaoxaheptadecane-1,17-diolHexagolHexaoxyethylene glycol2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanolDTXSID2058629CHEBI:497932-(2-(2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethanolRefChem:922913DTXCID0032316220-045-1
Show more names
PEG-6PEG6-OHOH-PEG6-OHLIPOXOL 300SKL259Hexago
HexaethyleneglycolHO-PEG6-OHMFCD00002877NSC 201209BRN 1638281AI3-01457C12H26O7Ethanol, 2,2'-(oxybis(ethyleneoxyethyleneoxy))di-

Database identifiers

CAS
2615-15-8
PubChem CID
17472
DTXSID
DTXSID2058629
ChEMBL
CHEMBL1235082
ChEBI
CHEBI:49793
EC Number
220-045-1
Nikkaji
J49.380E

Properties

Computed structural properties

XLogP
-1.9
Topological polar surface area
86.6 Ų
Hydrogen bond donors
2
Hydrogen bond acceptors
7
Rotatable bonds
16
Heavy atoms
19

Experimental & physicochemical properties

CosmeticsSolvent; Humectant
SurfactantsSurfactant
Food Contact SubstancesFCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR
Collision Cross Section158.09 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Physicochemical properties

Melting point
5 · 5-7 °C (lit.)
Boiling point
217 °C/4 · 217 °C/4 mmHg (lit.)
Density
1.127 g/mL · 1.127 g/mL at 25 °C (lit.)
refractive index
20 · n20/D 1.465(lit.)
Flash point
110 °C · >110°C
storage temp.
Sealed in dry,Room Temperature

Safety & regulation

GHS classification

GHS Classification · 5 items

This chemical does not meet GHS hazard criteria for 79.2% (141 of 178) of all reports.

Warning

H319 (20.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

P264+P265, P280, P305+P351+P338, and P337+P317 (click each P-code to see the statement)

Aggregated GHS information provided per 178 reports by companies from 4 notifications to the ECHA C&L Inventory.

Hazard information

Regulatory Information · 2 items

Chemical: 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol

Hexaethylene glycol: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Other Safety InformationIMAP assessments - 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol: Human health tier I assessment
EPA Safer ChemicalChemical: Hexaethylene glycol
Hazard Classes and CategoriesEye Irrit. 2A (20.8%)

Safety data

F
3
PPE
Eyeshields, Gloves
wgk
2
rtecs
MM3670000
hs_code
2909498090
Signal word
Warning

Chemistry & industry

Uses & manufacturing

Household ProductsInformation on 36 consumer products that contain PEG-6 in the following categories is provided:
Use Classification · 3 items

EPA Safer Chemical Functional Use Classes -> Processing Aids and Additives

Safer Chemical Classes -> Green half-circle - The chemical is expected to be of low concern

Cosmetics -> Solvent; Humectant

Applications · 4 items

DescriptionHexaethylene glycol is a polymer consisting of ethylene glycol monomers and two terminal hydroxyl groups. The PEG chain increases the water solubility of a compound in aqueous media. Increasing the number of ethylene glycol units within the entire chain improves the solubility properties of the PEG linker.

UsesSubstrate employed in the synthesis of binaphthol-based macrocyclic ethers using intramolecular oxidative coupling with CuCl(OH)-TMEDA.1

UsesHexaethylene glycol exhibits antioxidant, antimicrobial and anti-cancer properties. It also shows potential application as functional hydraulic fluids. It is used as a surfactant building block as well as used in biological sample preparation. Further, it is employed in the synthesis of binaphthol-based macrocyclic ethers using intramolecular oxidative coupling with CuCl(OH).

UsesHexaethylene Glycol is part of a leaf extract (Murdannia Bracteata) which exhibits antioxidant, antimicrobial and anti-cancer properties. It also shows potential application as functional hydraulic fl uids.

Upstream & downstream products

Suppliers50 total

国药集团化学试剂有限公司86-21-63210123 · [email protected]
北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
郑州阿尔法化工有限公司+86-18530059196 · [email protected]
衢州润东化工有限公司0570-8789886 18892685668 · [email protected]

Additional notes

DefinitionChEBI: Hexaethylene glycol is a poly(ethylene glycol).

Related reactions

69 records
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Linked notes

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