Hexaethylene Glycol
Basic information
- CAS
2615-15-8- Standard SMILES
OCCOCCOCCOCCOCCOCCO- InChIKey
IIRDTKBZINWQAW-UHFFFAOYSA-N- Molecular formula
- C12H26O7
- Average molar mass
- 282.33 g/mol
- Monoisotopic mass
- 282.16785316
Overview
Hexaethylene glycol is a poly(ethylene glycol).
Names & identifiers
- Preferred name
- Hexaethylene Glycol
- IUPAC
- 2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanol
- English name
- Hexaethylene glycol
- Molecular formula
- C12H26O7
- Molecular weight
- 282.33
Names & synonyms
HEXAETHYLENE GLYCOL2615-15-83,6,9,12,15-Pentaoxaheptadecane-1,17-diolHexagolHexaoxyethylene glycol2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanolDTXSID2058629CHEBI:497932-(2-(2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethanolRefChem:922913DTXCID0032316220-045-1
Show more names
PEG-6PEG6-OHLIPOXOL 300SKL259Hexago
HO-PEG6-OHHexaethyleneglycolMFCD00002877NSC 201209OH-PEG6-OHBRN 1638281Ethanol, 2,2'-(oxybis(ethyleneoxyethyleneoxy))di-AI3-01457
Database identifiers
- CAS
2615-15-8- PubChem CID
- 17472
- DTXSID
DTXSID2058629- ChEMBL
CHEMBL1235082- ChEBI
CHEBI:49793- EC Number
- 220-045-1
- Nikkaji
- J49.380E
Properties
Computed structural properties
- XLogP
- -1.9
- Topological polar surface area
- 86.6 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 7
- Rotatable bonds
- 16
- Heavy atoms
- 19
- Formal charge
- 0
- Complexity
- 141
Experimental & physicochemical properties
CosmeticsSolvent; Humectant
SurfactantsSurfactant
Food Contact SubstancesFCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR
Collision Cross Section158.09 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
Physicochemical properties
- Melting point
- 5 · 5-7 °C (lit.)
- Boiling point
- 217 °C/4 · 217 °C/4 mmHg (lit.)
- Density
- 1.127 g/mL · 1.127 g/mL at 25 °C (lit.)
- refractive index
- 20 · n20/D 1.465(lit.)
- Flash point
- 110 °C · >110°C
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Miscible with chloroform and methanol.
- form
- Oil
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 79.2% (141 of 178) of all reports.
Warning
H319 (20.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
P264+P265, P280, P305+P351+P338, and P337+P317 (click each P-code to see the statement)
Aggregated GHS information provided per 178 reports by companies from 4 notifications to the ECHA C&L Inventory.
Hazard information
Regulatory Information
Chemical: 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol
Hexaethylene glycol: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Other Safety InformationIMAP assessments - 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol: Human health tier I assessment
EPA Safer ChemicalChemical: Hexaethylene glycol
Hazard Classes and CategoriesEye Irrit. 2A (20.8%)
Safety data
- F
- 3
- PPE
- Eyeshields, Gloves
- wgk
- 2
- rtecs
- MM3670000
- hs_code
- 2909498090
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- safety_code
- 23-24/25
Chemistry & industry
Uses & manufacturing
Household ProductsInformation on 36 consumer products that contain PEG-6 in the following categories is provided:
Use Classification
EPA Safer Chemical Functional Use Classes -> Processing Aids and Additives
Safer Chemical Classes -> Green half-circle - The chemical is expected to be of low concern
Cosmetics -> Solvent; Humectant
Applications
DescriptionHexaethylene glycol is a polymer consisting of ethylene glycol monomers and two terminal hydroxyl groups. The PEG chain increases the water solubility of a compound in aqueous media. Increasing the number of ethylene glycol units within the entire chain improves the solubility properties of the PEG linker.
UsesSubstrate employed in the synthesis of binaphthol-based macrocyclic ethers using intramolecular oxidative coupling with CuCl(OH)-TMEDA.1
UsesHexaethylene glycol exhibits antioxidant, antimicrobial and anti-cancer properties. It also shows potential application as functional hydraulic fluids. It is used as a surfactant building block as well as used in biological sample preparation. Further, it is employed in the synthesis of binaphthol-based macrocyclic ethers using intramolecular oxidative coupling with CuCl(OH).
UsesHexaethylene Glycol is part of a leaf extract (Murdannia Bracteata) which exhibits antioxidant, antimicrobial and anti-cancer properties. It also shows potential application as functional hydraulic fl uids.
Upstream & downstream products
Downstream products
Related reactions
69 records
Compound notes
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