Basic information
- CAS
181630-15-9- Standard SMILES
Cc1ccccn1.N.[Cl][Pt][Cl]- InChIKey
IIMIOEBMYPRQGU-UHFFFAOYSA-L- Molecular formula
- C6H10Cl2N2Pt
- Average molar mass
- 376.14 g/mol
- Monoisotopic mass
- 374.986898
Overview
Picoplatin is a cytotoxic platinum compound in clinical development for the treatment of patients with solid tumors. It causes apoptosis (cell death) by binding to DNA and interfering with DNA replication and transcription.
Names & identifiers
- Preferred name
- CID 175381340
- IUPAC
- azane;dichloroplatinum;2-methylpyridine
- English name
- Picoplatin
- Molecular formula
- C6H9Cl2N2Pt
- Molecular weight
- 375.14
Names & synonyms
SCHEMBL28953303ZD0473NX 473Jm-473Amd-473Amd 473PicoplatinPicoplatin(AMD-473)AMD473NX 473ZD0473Amminedichloro(2-methylpyridine)platinium
Show more names
Azane 2-methylpyridine platinum(II) dichloride
Database identifiers
- CAS
181630-15-9- PubChem CID
- 175381340
Properties
Computed structural properties
- Topological polar surface area
- 13.9 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 0
- Heavy atoms
- 11
- Formal charge
- 0
- Complexity
- 72.8
Physicochemical properties
- form
- Solid
- color
- Light yellow to yellow
- EWG's Food Scores
- 1 · 1
- NCI Dictionary of Cancer Terms
- 473 · ZD0473
- FDA UNII
- 5 TAN0L720 · B5TAN0L720
- NCI Drug Dictionary
- picoplatin
- Symbol(GHS)
- 8 · GHS08,GHS05
- Signal word
- Danger
- Hazard statements
- 334 · H334-H317-H350-H290-H340
- Precautionary statements
- 261 · P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P261-P285-P304+P341-P342+P311-P501-P234-P390-P404
- RIDADR
- 2811 · 2811
- HazardClass
- 6.1 · 6.1(a)
- PackingGroup
- II
- Toxicity
- 50 in · LD50 in mice (mg/kg): 43 i.p., 560 orally (Murrer)
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- ridadr
- 2811
- Toxicity
- LD50 in mice (mg/kg): 43 i.p., 560 orally (Murrer)
- Signal word
- Danger
- Symbol(GHS)
- GHS08,GHS05
- hazard_class
- 6.1(a)
- packing_group
- II
- Hazard statements
- H334-H317-H350-H290-H340
- Precautionary statements
- P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P261-P285-P304+P341-P342+P311-P501-P234-P390-P404
Chemistry & industry
Pharmacology
PharmacodynamicsPicoplatin is a sterically hindered platinum (II) complex designed to deliver an extended spectrum of anti-cancer activity and overcome platinum resistance.
Mechanism of ActionPicoplatin causes apoptosis (cell death) by binding to DNA and interfering with DNA replication and transcription.
Applications
UsesTreatment of cancer.
UsesPicoplatin is an extended spectrum of antineoplastic activity.
Suppliers37 total
南通飞宇生物科技有限公司0513-68819626 15152877458 · [email protected]
武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
杭州鼎燕化工有限公司13588754826 13588754826 · [email protected]
湖南瑞威尔生物科技有限公司18627957289 18173226957 · [email protected]
上海波以尔化工有限公司[email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
欧利希（湖北）医药科技有限公司17316404525 17316404525 · [email protected]
广州爱纯医药科技有限公司
Related reactions
0 records
No reaction records under the current filter.
Compound notes
Loading…