2-Methylquinolin-4-ol

HCID 178428811CAS 607-67-0
Substructure searchFind similar structures

Basic information

Standard SMILES
Cc1cc(O)c2ccccc2n1
InChIKey
NWINIEGDLHHNLH-UHFFFAOYSA-N
Molecular formula
C10H9NO
Average molar mass
159.18 g/mol
Monoisotopic mass
159.06841391

Names & identifiers

Preferred name
2-Methylquinolin-4-ol
IUPAC
2-methyl-1H-quinolin-4-one
English name
4-Hydroxy-2-methylquinoline
Molecular formula
C10H9NO
Molecular weight
159.18

Names & synonyms

4-Hydroxy-2-methylquinoline2-Methylquinolin-4-ol607-67-0EINECS 210-140-6DTXSID40209515NSC 21483RefChem:476257DTXCID90132006210-140-62-methylquinolin-4(1H)-one2-Methyl-4-quinolinol2-methyl-1H-quinolin-4-one
Show more names
AKOS 914152-methylquinolinolTIMTEC-BB SBB0039794-HYDROXYQUINALDINE 98%2-Methyl-4-quinolinol >2-METHYL-4(1H)-QUINOLINONE
4-Quinolinol, 2-methyl-4-Hydroxyquinaldine2-Methyl-4-hydroxyquinoline4(1H)-Quinolinone, 2-methyl-MFCD000067582-Methyl-quinolin-4-ol1H-4-Oxoquinaldine2-methyl-quinolin-4(1H)-one

Database identifiers

CAS
607-67-0
PubChem CID
69089

Properties

Computed structural properties

XLogP
1.9
Topological polar surface area
29.1 Ų
Hydrogen bond donors
1
Hydrogen bond acceptors
2
Rotatable bonds
0
Heavy atoms
12

Physicochemical properties

Melting point
234 · 234-236 °C(lit.)
Boiling point
284.68 °C · 284.68°C (rough estimate)
Density
1.1202 · 1.1202 (rough estimate)
refractive index
1.607 · 1.6070 (estimate)
storage temp.
Sealed in dry,Room Temperature
form
powder to crystal

Safety & regulation

GHS classification

GHS Classification · 5 items

Warning

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]；H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H335 (97.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 45 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Hazard information

Hazard Classes and CategoriesSkin Irrit. 2 (100%)；Eye Irrit. 2 (100%)；STOT SE 3 (97.8%)

Safety data

PPE
dust mask type N95 (US), Eyeshields, Gloves
wgk
3
hs_code
29334900
risk_code
36/37/38
Signal word
Warning
Symbol(GHS)
GHS07

Chemistry & industry

Applications · 2 items

Uses4-Hydroxy-2-methylquinoline is act as an intermediate in the synthesis of dequalinium chloride and as pharmaceutical intermediate.

Uses4-Hydroxy-2-methylquinoline can be used as an intermediate in the synthesis of a wide range of medicinally important compounds such as:Synthesis of 2-(quinolin-4-yloxy)acetamides as potent antitubercular agents.Synthesis of 2-arylethenylquinoline derivatives for the treatment of Alzheimer′s disease.Synthesis of 1,10-diethoxy-1H-pyrano[4,3-b]quinolones as antibacterial agents.Synthesis of phenylimidazole-pyrazolo[1,5-c]quinazolines as potent phophodiesterase 10A (PDE10A) inhibitors.

Upstream & downstream products

Suppliers50 total

山东玖玥生物科技有限公司15553333686
国药集团化学试剂有限公司86-21-63210123 · [email protected]
河北凡博医药科技有限公司15588346797
常州帝通化工有限公司+86-0519-88298848 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

Additional notes

DefinitionChEBI: 2-Methyl-4-quinolinol is a member of quinolines.

Related reactions

25 records
New reaction record

Linked notes

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