Amino-PEG8-Amine
NH2-PEG8-NH2 · Amino-PEG8-Amine · H2N-PEG9-NH2 (HQ) · H2N-dPEG8-CH2CH2NH2 · 1,26-Diamino-3,6,9,12,15,18,21,24-octaoxahexacosane · 3,6,9,12,15,18,21,24-Octaoxahexacosane-1,26-diamine · H2N-PEG8-CH2CH2NH2/3,6,9,12,15,18,21,24-Octaoxahexacosane-1,26-diamine · 2-[2-[2-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanamine
Identifiers & Physical Properties
| CAS No. | 82209-36-7 |
|---|---|
| Molecular formula | C18H40N2O8 |
| Average molar mass | 412.5 g/mol |
| Monoisotopic mass | 412.27846624 g/mol |
| SMILES | NCCOCCOCCOCCOCCOCCOCCOCCOCCN |
| InChIKey | QNNWDQWXZAXENQ-UHFFFAOYSA-N |
| PubChem CID | 58177642 |
Chemical & Physical Properties
| XLogP | -2.8 |
|---|---|
| Topological polar surface area | 126 |
| Hydrogen bond donors | 2 |
| Hydrogen bond acceptors | 10 |
| Rotatable bonds | 25 |
| Heavy atoms | 28 |
| Formal charge | 0 |
| Complexity | 252 |
| Storage conditions | -20°C |
| Solubility | Soluble in Water, DMSO, DCM, DMF |
| Physical state | Liquid |
| Color | Colorless to light yellow |
| InChI | InChI=1S/C18H40N2O8/c19-1-3-21-5-7-23-9-11-25-13-15-27-17-18-28-16-14-26-12-10-24-8-6-22-4-2-20/h1-20H2 |
| InChIKey | QNNWDQWXZAXENQ-UHFFFAOYSA-N |
| SMILES | C(N)COCCOCCOCCOCCOCCOCCOCCOCCN |
| UNSPSC Code | 51171641 |
| NACRES | NA.23 |
| GHS pictogram | GHS07 |
| Signal word | Warning |
| GHS hazard statements | H315-H319-H335 |
| GHS precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501 |
| Water hazard class (WGK) | WGK 3 |
| Storage class | 11 - Combustible Solids |
| Hazard class | Acute Tox. 4 OralEye Irrit. 2Skin Irrit. 2 |
Safety & Regulations
| Water hazard class (WGK) | WGK 3 |
|---|---|
| Signal word | Warning |
| GHS pictogram | GHS07 |
| Storage class | 11 - Combustible Solids |
| GHS hazard statements | H315-H319-H335 |
| Hazard class | Acute Tox. 4 OralEye Irrit. 2Skin Irrit. 2 |
| GHS precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501 |
Applications & Uses
Description
Amino-PEG8-Amine is a conjugation linker containing two amine (NH2) groups. The hydrophilic PEG spacer increases solubility in aqueous media. The amino groups are reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.
Uses
Amino-PEG8-amine is a PEG-based (8 units) PROTAC linker can be used in the synthesis of PROTACs[1].
Uses
Applications may include: bioconjugation, drug delivery, PEG hydrogel, crosslinker, and surface functionalization
General Description
Amino-PEG8-amine (CAS 82209-36-7), also known as H₂N-PEG8-CH₂CH₂NH₂ and NH₂-PEG8-NH₂, is a high-purity, symmetrical, homobifunctional, discrete PEG linker. Its molecular weight is 412.52. It is soluble in water, DMSO, DCM and DMF. At room temperature, it is typically a pale yellow to colourless viscous liquid or a low-melting-point waxy solid.