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101462-82-2101462-82-2Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
DescriptionCGRP is a vasodilative neuropeptide synthesized mainly in the central nervous system. It is a transmitter of nociceptive signals in relation to migraines. The presence of CGRP-α (or αCGRP) mRNA formed by alternative splicing from the calcitonin gene (CALCA) was reported in 1982, and it was isolated in 1984 from human medullary thyroid calcinoma. CGRP-β (or βCGRP) was identified by human genome analysis in 1985.
Usesβ-CGRP, human (Human β-CGRP) is one of calcitonin peptides, acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC50s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells[1].
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