Basic information
- CAS
2314467-60-0- Standard SMILES
CN1CCN(c2nc3c(F)cccc3c(=O)n2-c2ccc(Oc3ccc(F)cc3)cc2)CC1.Cl- InChIKey
ONVDBGZQVBEFIO-UHFFFAOYSA-N- Molecular formula
- C25H23ClF2N4O2
- Average molar mass
- 484.9 g/mol
- Monoisotopic mass
- 484.14776
Names & identifiers
- Preferred name
- TRPV4 agonist-1
- IUPAC
- 8-fluoro-3-[4-(4-fluorophenoxy)phenyl]-2-(4-methylpiperazin-1-yl)quinazolin-4-one;hydrochloride
- English name
- TRPV4 agonist-1
- Molecular formula
- C25H23ClF2N4O2
- Molecular weight
- 484.93
Names & synonyms
TRPV4 agonist-12314467-60-08-Fluoro-3-(4-(4-fluorophenoxy)phenyl)-2-(4-methylpiperazin-1-yl)quinazolin-4(3H)-one hydrochloride4(3H)-Quinazolinone, 8-fluoro-3-[4-(4-fluorophenoxy)phenyl]-2-(4-methyl-1-piperazinyl)-, hydrochloride (1:1)8-fluoro-3-[4-(4-fluorophenoxy)phenyl]-2-(4-methylpiperazin-1-yl)quinazolin-4-one;hydrochlorideOUN67600C25H23ClF2N4O2orb1218362orb1708318CHEMBL4557733EX-A4746OUN67600(TRPV4 agonist-1)?
Show more names
TRPV4 agonistRPV4 agonist-1OUN67600(TRPV4 agonist-1)TRPV4 agonist1,TRPV-4 agonist-1,TRPV4 agonist 1
AKOS040740461HY-114400ACS-0146221T13214
Database identifiers
- CAS
2314467-60-0- PubChem CID
- 137628675
- ChEMBL
CHEMBL4557733
Properties
Computed structural properties
- Topological polar surface area
- 48.4 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 6
- Rotatable bonds
- 4
- Heavy atoms
- 34
- Formal charge
- 0
- Complexity
- 713
Physicochemical properties
- storage temp.
- -20 °C · Store at -20°C
Chemistry & industry
Applications
DescriptionOUN67600, is a Novel Transient Receptor Potential Vanilloid 4 (TRPV4) Agonist as Regulators of Chondrogenic Differentiation. OUN67600 was first reported by Atobe et al (compound 36 in J Med Chem. 2019 Feb 14;62(3):1468-1483). This product has no formal name at the moment.
UsesTRPV4 agonist-1 is a transient receptor potential vanilloid 4 (TRPV4) agonist with an EC50 of 60 nM in the hTRPV4 Ca2+ assay[1].
Suppliers10 total
InvivoChem中国13549236410 · [email protected]
济南德迈医药科技有限公司18669728830 15806766175 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
上海陶术生物科技股份有限公司13564774135 · [email protected]
ATK CHEMICAL COMPANY LIMITED+undefined-21-51877795 · [email protected]
山东鸿图生物科技有限公司15318761660 15966937598 · [email protected]
上海杰瑞兴生物医药科技有限公司17521512546 17721492509 · [email protected]
TargetMol中国（陶术生物）4008200310 15002144251 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354 · [email protected]
InvivoChem+1-708-310-1919 +1-13798911105 · [email protected]
Related reactions
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Compound notes
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