Basic information
- CAS
2353410-11-2- Standard SMILES
[N-]=[N+]=NCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)NN- InChIKey
XSHZSHNFUKYUOV-UHFFFAOYSA-N- Molecular formula
- C19H39N5O9
- Average molar mass
- 481.5 g/mol
- Monoisotopic mass
- 481.27477784
Names & identifiers
- Preferred name
- Azido-PEG8-hydrazide
- IUPAC
- 3-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanehydrazide
- English name
- Azido-PEG8-hydrazide
- Molecular formula
- C19H39N5O9
- Molecular weight
- 481.55
Names & synonyms
Azido-PEG8-hydrazide2353410-11-21-azido-3,6,9,12,15,18,21,24-octaoxaheptacosane-27-hydrazideorb1988693SCHEMBL30737963AKOS0407429903-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanehydrazideBP-24118DA-61446HY-140815CS-0115256H84375
Show more names
T17520
Database identifiers
- CAS
2353410-11-2- PubChem CID
- 134827770
Properties
Computed structural properties
- XLogP
- -1.5
- Topological polar surface area
- 143 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 12
- Rotatable bonds
- 27
- Heavy atoms
- 33
- Formal charge
- 0
- Complexity
- 471
Physicochemical properties
- solubility
- Soluble in Water
- form
- Solid
- color
- White to off-white
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302-H315-H319-H335
- Precautionary statements
- 261 · P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501
Chemistry & industry
Applications
DescriptionAzido-PEG8-hydrazide HCl salt is a wter soluble PEG linker containing an azide group and a hydrazide moiety. The hydrophilic PEG spacer increases solubility of a compound in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The hydrazide group can react with an aldehyde to form a semi-permanent hydrozone bond.
UsesAzido-PEG8-hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG8-hydrazide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Suppliers22 total
吉林省创力生物科技有限公司19396231124 19396231124 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
Aladdin Scientific[email protected]
山东大有药物研发有限公司[email protected] 15165037910 · [email protected]
吉林中科研伸科技有限公司0431-80514535 19917294565 · [email protected]
上海皓鸿生物医药科技有限公司400-8210725 4008210725 · [email protected]
武汉翱联生物科技有限公司15841022315 15841022315 · [email protected]
金瓯生物医药（南京）有限公司13000000000 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
Loading…