PT-ttpy
Basic information
- CAS
727721-37-1- Standard SMILES
Cc1ccc(-c2cc3[n+]4c(c2)-c2cccc[n+]2[Pt-2]4([Cl])[n+]2ccccc2-3)cc1.[Cl-]- InChIKey
UWAUJHRZLKCPPX-UHFFFAOYSA-L- Molecular formula
- C22H17Cl2N3Pt
- Average molar mass
- 589.38 g/mol
Names & identifiers
- Preferred name
- PT-ttpy
- English name
- PT-ttpy
- Molecular formula
- C22H17Cl2N3Pt
- Molecular weight
- 589.38
Names & synonyms
PT-ttpyChloro[4'-(4-methylphenyl)-2,2':6',2''-terpyridine] Platinum(II) chloride
Database identifiers
- CAS
727721-37-1
Properties
Physicochemical properties
- storage temp.
- 2 · 2-8°C
- solubility
- 0.2 mg/mL · DMSO: 0.2mg/mL (warmed)
- form
- powder
- color
- faint yellow to dark orange
- InChI
- 1S/C22H17N3.2ClH.Pt/c1-16-8-10-17(11-9-16)18-14-21(19-6-2-4-12-23-19)25-22(15-18)20-7-3-5-13-24-20;;;/h2-15H,1H3;2*1H;/q;;;+2/p-2
- InChIKey
- UWAUJHRZLKCPPX-UHFFFAOYSA-L
- SMILES
- CC1=CC=C(C2=CC(C3=[N+]4C=CC=C3)=[N+]5C(C6=CC=CC=[N+]6[Pt-2]54Cl)=C2)C=C1.[Cl-]
- UNSPSC Code
- 12352200 · 12352200
- NACRES
- 77 · NA.77
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 315 · H315-H319
- Precautionary statements
- 264 · P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
- WGK Germany
- 3 · WGK 3
- Storage Class
- 13 · 13 - Non Combustible Solids
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- wgk
- WGK 3
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Storage Class
- 13 - Non Combustible Solids
- Hazard statements
- H315-H319
- Precautionary statements
- P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Chemistry & industry
Applications
UsesPt-ttpy, a metallo-organic complex and potent G-quadruplex ligand, effectively triggers substantial telomere-related DNA damage in cancer cells by inhibiting telomerase and/or telomere functions, while also causing various chromatin abnormalities during mitosis, such as chromatin bridges, ultrafine bridges (UFBs), and double-stranded breaks (DSBs).
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Related reactions
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Compound notes
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