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Basic information
- CAS
1469902-72-4- Standard SMILES
COc1ccc2c(c1)c(CC(=O)O)c(C)n2Cc1ccc(Cl)cc1- InChIKey
ZCEPWIDYPWMCOY-UHFFFAOYSA-N- Molecular formula
- C19H18ClNO3
- Average molar mass
- 343.8 g/mol
Names & identifiers
- Preferred name
- 1-(4-CHLOROBENZYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID
- English name
- 1-(4-CHLOROBENZYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID
- Molecular formula
- C19H18ClNO3
- Molecular weight
- 343.8
Names & synonyms
Kv1.5IN4Kv1.5INIVCOMPOUND 4Kv1.5INIIIICompound IIIIKv1.5-IN-IIIIKv-1.5-IN-IIII,Kv1.5 IN IIII1-(4-CHLOROBENZYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID
Database identifiers
- CAS
1469902-72-4
Properties
Physicochemical properties
- solubility
- 10 mg/mL, · DMSO: 10 mg/mL, soluble
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 315 · H315-H319-H335
- Precautionary statements
- 261 · P261-P305+P351+P338
- Hazard Codes
- Xi
- Risk Statements
- 36 · 36/37/38
- Safety Statements
- 26 · 26-36
- WGK Germany
- 3 · 3
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- wgk
- 3
- risk_code
- 36/37/38
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- Xi
- safety_code
- 26-36
- Hazard statements
- H315-H319-H335
- Precautionary statements
- P261-P305+P351+P338
Chemistry & industry
Applications
UsesKv1.5-IN-1 is a Kv1.5 channel inhibitor. Its target selectivity and pharmacodynamic effects were evaluated in an in vitro rat model. After the introduction of a methoxy group at the R5 position, Kv1.5-IN-1 showed inhibitory potency similar to that of the unsubstituted compound. Its IC50 value for hKv1.5 channels was 0.51 μM. Kv1.5-IN-1 exhibited a high degree of selectivity, nearly 2,600 times higher than compound Ik and 300 times higher than compound IId, indicating that it may be a safe inhibitor. Due to its good pharmacological behavior, Kv1.5-IN-1 deserves further pharmacodynamic and pharmacokinetic evaluation. These properties make Kv1.5-IN-1 a potential Kv1.5 channel inhibitor that may have application prospects in the treatment of related diseases.
Suppliers3 total
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
上海陶术生物科技股份有限公司13564774135 · [email protected]
TargetMol中国（陶术生物）4008200310 15002144251 · [email protected]
Related reactions
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Compound notes
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