Basic information
- CAS
2055023-76-0- Standard SMILES
CC(C)(C)OC(=O)CCOCCOCCOCCOCCS(=O)(=O)CCOCCOCCOCCN=[N+]=[N-]- InChIKey
MSDYLVAJNIFYGM-UHFFFAOYSA-N- Molecular formula
- C23H45N3O11S
- Average molar mass
- 571.7 g/mol
- Monoisotopic mass
- 571.27748043
Names & identifiers
- Preferred name
- Azido-PEG3-Sulfone-PEG4-Boc
- IUPAC
- tert-butyl 3-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethylsulfonyl]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
- English name
- Azido-PEG3-Sulfone-PEG4-t-butyl ester
- Molecular formula
- C23H45N3O11S
- Molecular weight
- 571.6819
Names & synonyms
Azido-PEG3-Sulfone-PEG4-Boc2055023-76-0Azido-PEG3-Sulfone-PEG4-t-butyl estertert-butyl 1-(2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}ethanesulfonyl)-3,6,9,12-tetraoxapentadecan-15-oateAZIDO-PEG3-SULFONE-PEG4-T-BUTYLESTERorb1988703AKOS040742980BP-23242DA-61430tert-butyl 3-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethylsulfonyl]ethoxy]ethoxy]ethoxy]ethoxy]propanoateHY-140604CS-0114976
Show more names
C70755T17508R14-0072tert-Butyl 1-((2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl)sulfonyl)-3,6,9,12-tetraoxapentadecan-15-oate
Database identifiers
- CAS
2055023-76-0- PubChem CID
- 123132141
Properties
Computed structural properties
- XLogP
- 0.3
- Topological polar surface area
- 148 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 13
- Rotatable bonds
- 29
- Heavy atoms
- 38
- Formal charge
- 0
- Complexity
- 721
Chemistry & industry
Applications
DescriptionAzido-PEG3-Sulfone-PEG4-t-butyl ester is a PEG linker containing one azide group and one t-butyl protected carboxyl group. The azide group enables Click Chemistry. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group (COOH) prevents self coupling or polymerization under standard acid/amine or acid/hydroxyl coupling conditions.
UsesAzido-PEG3-Sulfone-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG3-Sulfone-PEG4-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Suppliers17 total
Aladdin Scientific[email protected]
山东大有药物研发有限公司[email protected] 15165037910 · [email protected]
吉林中科研伸科技有限公司18143011203 · [email protected]
台州川旭医药科技有限公司[email protected] 15165038510 · [email protected]
上海研纷生化科技有限公司13611955358 15002190549 · [email protected]
Xian confluore Biological Technology Co., Ltd.+86-15680926068 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
南京世洲生物科技有限公司025-85563444 18351873721 · [email protected]
Related reactions
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Compound notes
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