Basic information
- CAS
1418747-15-5- Standard SMILES
CC(C)(C)OC(=O)N1CC(Nc2nc3ncccc3c(=O)[nH]2)C1- InChIKey
CKUDSTVQYFRZJW-UHFFFAOYSA-N- Molecular formula
- C15H19N5O3
- Average molar mass
- 317.34 g/mol
Names & identifiers
- Preferred name
- 1-Azetidinecarboxylic acid, 3-[(3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-, 1,1-dimethylethyl ester
- English name
- 1-Azetidinecarboxylic acid, 3-[(3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-, 1,1-dimethylethyl ester
- Molecular formula
- C15H19N5O3
- Molecular weight
- 317.34
Names & synonyms
AZ3976, 10 mM in DMSO1-Boc-3-(4-Oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino)-azetidinetert-butyl 3-({4-oxo-1H,4H-pyrido[2,3-d]pyrimidin-2-yl}amino)azetidine-1-carboxylatetert-Butyl 3-((4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)azetidine-1-carboxylate1-Azetidinecarboxylic acid, 3-[(3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-, 1,1-dimethylethyl ester
Database identifiers
- CAS
1418747-15-5
Properties
Physicochemical properties
- Boiling point
- 490.3 · 490.3±55.0 °C(Predicted)
- Density
- 1.42 · 1.42±0.1 g/cm3(Predicted)
- pka
- 1.11 · 1.11±0.20(Predicted)
- form
- Solid
- color
- White to off-white
Chemistry & industry
Applications
UsesAZ3976 is a potent plasminogen activator inhibitor type 1 (PAI-1) inhibitor with an IC50value of 26 μMin an enzymatic chromogenic assay. AZ3976 is active with an IC50of 16 μM in a plasma clot lysis assay.AZ3976 does not bind to active PAI-1 but bound reversibly to latent PAI-1. AZ3976 inhibits PAI-1 by enhancing the latency transition of active PAI-1. AZ3976 displays profibrinolytic activities in a human plasma clot lysis assay[1].
Suppliers21 total
沈阳中申泽康生物医学技术研究有限公司024-88590548 18698872706 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]
Aladdin Scientific[email protected]
銳迪國際科技有限公司18024082417 · [email protected]
深圳市星跃生物科技有限公司18124513697; 18124513697 · [email protected]
上海楼岚生物科技有限公司021-52996696，15000506266 15000506266
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
BOC Sciences16314854226; +8616314854226 · [email protected]
Related reactions
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Compound notes
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