HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-methoxyphenyl)-N-[(4-propan-2-ylphenyl)methyl]benzimidazol-5-amine
ST-193 · ST-193 hydrochlorid · ST-193, 10 mM in DMSO · ST193 HYDROCHLORIDE · ST 193 HYDROCHLORIDE · ST-193,inhibit,Inhibitor,Arenavirus,ST193,ST 193 · 1H-Benzimidazol-5-amine, 1-(4-methoxyphenyl)-N-[[4-(1-methylethyl)phenyl]methyl]-
![1-(4-methoxyphenyl)-N-[(4-propan-2-ylphenyl)methyl]benzimidazol-5-amine molecular structure](/img/chemical/178713402.png)
Identifiers & Physical Properties
| CAS No. | 489416-12-8 |
|---|---|
| Molecular formula | C24H25N3O |
| Average molar mass | 371.5 g/mol |
| Monoisotopic mass | 371.19976243 g/mol |
| SMILES | COc1ccc(-n2cnc3cc(NCc4ccc(C(C)C)cc4)ccc32)cc1 |
| InChIKey | JPSZEXYTKSIPDW-UHFFFAOYSA-N |
| PubChem CID | 3697969 |
| ChEMBL | CHEMBL2314859 |
Chemical & Physical Properties
| XLogP | 5.7 |
|---|---|
| Topological polar surface area | 39.1 |
| Hydrogen bond donors | 1 |
| Hydrogen bond acceptors | 3 |
| Rotatable bonds | 6 |
| Heavy atoms | 28 |
| Formal charge | 0 |
| Complexity | 468 |
| Boiling point | 562.5±60.0 °C(Predicted) |
| Density | 1.12±0.1 g/cm3(Predicted) |
| Storage conditions | Store at -20°C |
| Solubility | DMSO: ≥ 150 mg/mL (403.80 mM) |
| pKa (acidity coefficient) | 5.20±0.10(Predicted) |
| Physical state | Solid |
| Color | Off-white to pink |
Applications & Uses
Uses
ST-193 is a potent broad-spectrum arenavirus inhibitor; inhibits Guanarito, Junin, Lassa and Machupo virus with IC50 values of 0.44, 0.62, 1.4 and 3.1 nM, respectively.