Basic information
- CAS
168635-85-6- Standard SMILES
CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)O- InChIKey
JHESAKNQFPFWLN-UOGODTEOSA-N- Molecular formula
- C43H69N11O14
- Average molar mass
- 964.1 g/mol
Overview
Carcinoembryonic Antigen Peptide 1 is a nine amino acid peptide fragment of carcinoembryonic antigen (CEA), a protein that is overexpressed in several cancer cell types, including gastrointestinal, breast, and non-small cell lung. Autologous vaccination with activated autologous dendritic cells (DC) or peripheral blood mononuclear cells (PBMC) which have been exposed to CEA peptide 1 in vitro may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells expressing CEA, thereby inhibiting tumor growth. (NCI04)
Names & identifiers
- Preferred name
- Carcinoembryonic Antigen CEA
- IUPAC
- (2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]acetyl]amino]propanoyl]amino]-4-oxobutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-4-methylpentanoic acid
- English name
- CARCINOEMBRYONIC ANTIGEN (CEA)
- Molecular formula
- C43H69N11O14
- Molecular weight
- 964.07
Names & synonyms
168635-85-6Carcinoembryonic Antigen CEACarcinoembryonic Antigen (CEA)Carcinoembryonic antigen peptide 1(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]acetyl]amino]propanoyl]amino]-4-oxobutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-4-methylpentanoic acidCEA peptideCARCINOEMBRYONIC ANTIGENorb321475orb1296677C43H69N11O14MFCD06657932TP1286
Show more names
Carcinoembryonic antigen peptideinhibit,Carcinoembryonic Antigen (CEA),Inhibitor,Carcinoembryonic Antigen CEAL-Tyrosyl-L-leucyl-L-serylglycyl-L-alanyl-L-asparaginyl-L-leucyl-L-asparaginyl-L-leucineL-Leucine, L-tyrosyl-L-leucyl-L-serylglycyl-L-alanyl-L-asparaginyl-L-leucyl-L-asparaginyl-
AKOS040763953DA-62064MS-31810G13358(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-4-methyl-pentanoyl]amino]-3-hydroxy-propanoyl]amino]acetyl]amino]propanoyl]amino]-4-oxo-butanoyl]amino]-4-methyl-pentanoyl]amino]-4-oxo-butanoyl]amino]-4-methyl-pentanoic acid
Properties
Computed structural properties
- XLogP
- -4.3
- Topological polar surface area
- 423 Ų
- Hydrogen bond donors
- 14
- Hydrogen bond acceptors
- 15
- Rotatable bonds
- 30
- Heavy atoms
- 68
- Formal charge
- 0
- Complexity
- 1,770
Physicochemical properties
- Boiling point
- 1471.7 · 1471.7±65.0 °C(Predicted)
- Density
- 1.289 · 1.289±0.06 g/cm3(Predicted)
- storage temp.
- -20 °C, · -20°C, protect from light
- form
- Solid
- pka
- 3.35 · 3.35±0.10(Predicted)
- color
- White to off-white
- Water Solubility
- Soluble in Water
- Sequence
- H-Tyr-Leu-Ser-Gly-Ala-Asn-Leu-Asn-Leu-OH
Chemistry & industry
Applications
UsesCarcinoembryonic antigen peptide 1 (CEA peptide) is a carcinoembryonic antigen (CEA)-derived peptide. Carcinoembryonic antigen peptide 1 is a potential HLA-A*0201-restricted CTL epitope that can be used for the study of CTL-mediated epithelial-derived cancers[1].
Suppliers42 total
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
Aladdin Scientific[email protected]
上海鸿肽生物科技有限公司15318089928 · [email protected]
Hybio Pharmaceutical Co., Ltd.+86-18964595316 +86-13135669090 · [email protected]
中科华药(江苏)生物科技有限公司18020125070 · [email protected]
杭州思诺达医药科技有限责任公司0571-87213919 17306812703 · [email protected]
MedChemexpress LLC021-58955995 · [email protected]
Zhejiang J&C Biological Technology Co.,Limited+1-2135480471 · [email protected]
湖北魏氏化学试剂股份有限公司17771898297 13125137661 · [email protected]
Creative Peptides[email protected]
康明永瑞生物科技（苏州）有限公司17751201929; 17751201929 · [email protected]
Related reactions
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Compound notes
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