Biotin-PEG2-Azide
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Basic information
- CAS
945633-30-7- Standard SMILES
[N-]=[N+]=NCCOCCOCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21- InChIKey
OVEZMVONEJMGLZ-YDHLFZDLSA-N- Molecular formula
- C16H28N6O4S
- Average molar mass
- 400.5 g/mol
- Monoisotopic mass
- 400.18927457
Names & identifiers
- Preferred name
- Biotin-PEG2-Azide
- IUPAC
- 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[2-[2-(2-azidoethoxy)ethoxy]ethyl]pentanamide
- English name
- Biotin-PEG3-N3
- Molecular formula
- C16H28N6O4S
- Molecular weight
- 400.5
Names & synonyms
945633-30-7Biotin-PEG2-AzideBiotin-PEG2-CH2CH2N3(+)-Biotin-PEG2-azideBiotin PEG3 azideMFCD26142991N-(2-(2-(2-azidoethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide(+)-Biotin-PEG?-azide5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[2-[2-(2-azidoethoxy)ethoxy]ethyl]pentanamide(+)-Biotin-PEG2-CH2CH2N3C16H28N6O4S5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl]-N-{2-[2-(2-azidoethoxy)ethoxy]ethyl}pentanamide
Show more names
Biotin-PEG3-azideBiotin-PEG3-N3Biotin-PEG2-N3Biotin-NH-PEG2-N3Reaxys ID: 18922506(+)-Biotin-PEG2-CH2CH2azide
(+)-Biotin-PEG3-azideorb1307525SCHEMBL20118030AKOS040743026Biotin-PEG2-Azide, Biotin PEG2 AzideAS-79359BP-22118DA-59423
Database identifiers
- CAS
945633-30-7- PubChem CID
- 77078237
- Nikkaji
- J2.638.403F
Properties
Computed structural propertiesFilling in
- XLogP
- 0.7
- Topological polar surface area
- 128 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 7
- Rotatable bonds
- 14
- Heavy atoms
- 27
- Formal charge
- 0
- Complexity
- 531
Physicochemical properties
- storage temp.
- 2 · Storage temp. 2-8°C
- solubility
- Soluble in Water, DMSO, DCM, DMF
- form
- Solid
- color
- White to off-white
- Appearance
- colorless solid
Chemistry & industry
Applications
DescriptionBiotin-PEG2-azide is a click chemistry biotinylation reagent. The azide group enable Click Chemistry reaction with alkyne, DBCO, BCN or prppargyl moiety to form a stable triazole linkage.
UsesBiotin-PEG2-CH2CH2N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Biotin-PEG2-CH2CH2N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Related reactions
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Compound notes
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