Basic information
- CAS
936749-12-1- Standard SMILES
CN1CC[C@@H](c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)[C@@H]1CO.Cl- InChIKey
OOVTUOCTLAERQD-OJMBIDBESA-N- Molecular formula
- C21H21Cl2NO5
- Average molar mass
- 438.3 g/mol
Overview
Riviciclib Hydrochloride is the hydrochloride salt form of riviciclib, a flavone and cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity. Riviciclib selectively binds to and inhibits Cdk4/cyclin D1, Cdk1/cyclin B and Cdk9/cyclin T1, serine/threonine kinases that play key roles in the regulation of the cell cycle and cellular proliferation. Inhibition of these kinases leads to cell cycle arrest during the G1/S transition, thereby leading to an induction of apoptosis, and inhibition of tumor cell proliferation.
Names & identifiers
- Preferred name
- P 276-00
- IUPAC
- 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl]chromen-4-one;hydrochloride
- English name
- P 276-00
- Molecular formula
- C21H21Cl2NO5
- Molecular weight
- 438.30114
Names & synonyms
920113-03-7Riviciclib hydrochlorideP276-00DRP53ZDY6HP-27600P 276-00P-276-004H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methyl-3-pyrrolidinyl)-, hydrochloride (1:1)RefChem:928418P2762-(2-Chlorophenyl)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl)-4H-chromen-4-one hydrochlorideRiviciclib HCl
Show more names
2-(2-chlorophenyl)-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl]chromen-4-one;hydrochlorideUNII-DRP53ZDY6H2-(2-chlorophenyl)-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl]-4H-chromen-4-one hydrochloride920113-03-7 (HCl)SCHEMBL663220orb1685539CHEMBL3991935SCHEMBL29387962
Database identifiers
- CAS
936749-12-1- ChEMBL
CHEMBL2312181、CHEMBL3991935- UNII
- DRP53ZDY6H
Properties
Computed structural properties
- Topological polar surface area
- 90.2 Ų
- Hydrogen bond donors
- 4
- Hydrogen bond acceptors
- 6
- Rotatable bonds
- 3
- Heavy atoms
- 29
- Formal charge
- 0
- Complexity
- 628
Chemistry & industry
Applications
UsesP276-00 is a cyclin-dependent kinase (CDK) inhibitor. P276-00 has shown to be highly selective for cancer cells and has shown to produce potent inhibition of Cdk4-D1 activity. P276-00 also induces apoptosis in human promyelocytic leukemia (HL-60) cells.
Suppliers7 total
Nantong HI-FUTURE Biology Co., Ltd.+86-18051384581 · [email protected]
Wuhan NCE Biomedical Co.,Ltd.4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
上海孚一生物科技有限公司+86 (21) 61124340
斯派螺（武汉）药物研发有限公司[email protected]
武汉研哲科技有限公司15527250409 · [email protected]
南通全益生物科技有限公司+86-0513; 18051384581 · [email protected]
南京克罗托鲁宁医药科技有限公司13382066392
Related reactions
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Compound notes
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