H-Pro-Ala-Gly-Ala-Ser-Arg-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro-OH
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Basic information
- CAS
875910-01-3- Standard SMILES
CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)O- InChIKey
PADLNMCKGYDJBW-WMFAMTTMSA-N- Molecular formula
- C78H134N20O24
- Average molar mass
- 1,736 g/mol
Names & identifiers
- Preferred name
- H-Pro-Ala-Gly-Ala-Ser-Arg-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro-OH
- IUPAC
- (2S)-1-[(2S)-2-[[(2S)-3-carboxy-2-[[(2S,3S)-2-[[(2S)-4-carboxy-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-3-hydroxy-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-pyrrolidine-2-carbonyl]amino]propanoyl]amino]acetyl]amino]propanoyl]amino]propanoyl]amino]pentanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]butanoyl]amino]-3-methylpentanoyl]amino]propanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carboxylic acid
- English name
- AGA-(C8R) HNG17, Humanin derivative
- Molecular formula
- C78H134N20O24
- Molecular weight
- 1736.05
Names & synonyms
875910-01-3orb1983992TP1524PAGASRLLLLTGEIDLPAGA-(C8R) HNG17, Humanin derivativeL-Proline, L-prolyl-L-alanylglycyl-L-alanyl-L-seryl-L-arginyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-threonylglycyl-L-α-glutamyl-L-isoleucyl-L-α-aspartyl-L-leucyl-
Database identifiers
- CAS
875910-01-3
Properties
Computed structural propertiesFilling in
- XLogP
- -3.2
- Topological polar surface area
- 686 Ų
- Hydrogen bond donors
- 23
- Hydrogen bond acceptors
- 26
- Rotatable bonds
- 55
- Heavy atoms
- 122
- Formal charge
- 0
- Complexity
- 3,630
Physicochemical properties
- Density
- 1.41 · 1.41±0.1 g/cm3(Predicted)
- pka
- 3.42 · 3.42±0.20(Predicted)
Chemistry & industry
Applications
UsesAGA-(C8R) HNG17, Humanin derivative is a potent humanin (HN) derivative. AGA-(C8R) HNG17, Humanin derivative completely suppresses neuronal cell death by Alzheimer's disease-relevant insults[1].
Related reactions
0 records
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Compound notes
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