2'-O-Methyl-5-methyl-4-thiouridine
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Basic information
- CAS
2095417-26-6- Standard SMILES
CO[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1n1cc(C)c(=S)[nH]c1=O- InChIKey
UIBLINQYGJCXTO-FDDDBJFASA-N- Molecular formula
- C11H16N2O5S
- Average molar mass
- 288.32 g/mol
Names & identifiers
- Preferred name
- 2'-O-Methyl-5-methyl-4-thiouridine
- IUPAC
- 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-5-methyl-4-sulfanylidenepyrimidin-2-one
- English name
- 2'-O-Methyl-5-methyl-4-thiouridine
- Molecular formula
- C11H16N2O5S
- Molecular weight
- 288.32
Names & synonyms
2095417-26-62'-O-Methyl-5-methyl-4-thiouridineorb1908741TNU02382’-O-Methyl-5-methyl-4-thiouridine1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-5-methyl-4-thioxo-3,4-dihydropyrimidin-2(1H)-one
Database identifiers
- CAS
2095417-26-6
Properties
Computed structural propertiesFilling in
- XLogP
- -0.8
- Topological polar surface area
- 123 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 6
- Rotatable bonds
- 3
- Heavy atoms
- 19
- Formal charge
- 0
- Complexity
- 427
Chemistry & industry
Applications
Uses2’-O-Methyl-5-methyl-4-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related reactions
0 records
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Compound notes
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