Azido-PEG2-NHS ester
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Basic information
- CAS
1312309-64-0- Standard SMILES
[N-]=[N+]=NCCOCCOCCC(=O)ON1C(=O)CCC1=O- InChIKey
XDXWXTIRKQZRNN-UHFFFAOYSA-N- Molecular formula
- C11H16N4O6
- Average molar mass
- 300.27 g/mol
Names & identifiers
- Preferred name
- Azido-PEG2-NHS ester
- IUPAC
- (2,5-dioxopyrrolidin-1-yl) 3-[2-(2-azidoethoxy)ethoxy]propanoate
- English name
- Azido-PEG2-NHS ester
- Molecular formula
- C11H16N4O6
- Molecular weight
- 300.27
Names & synonyms
Azido-PEG2-NHS ester1312309-64-0N3-PEG2-C2-NHS ester2,5-dioxopyrrolidin-1-yl 3-(2-(2-azidoethoxy)ethoxy)propanoateMFCD20926376Propanoic acid, 3-[2-(2-azidoethoxy)ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester(2,5-dioxopyrrolidin-1-yl) 3-[2-(2-azidoethoxy)ethoxy]propanoateN3-PEG2-CH2CH2COONHS EsterAzido-PEG2-NHSN3-PEG2-SPAC11H16N4O6orb1989015
Show more names
N3-PEG2-OsuN3-PEG2-PA-NHSN3-PEG2-CH2CO2-NHSN3-PEG2-CH2CH2COONHSAzido-PEG2-CH2CO2-NHS
SCHEMBL14713434DTXSID401118503MCC30964AKOS040742258AS-78239BP-20524PD171730SY034936
Database identifiers
- CAS
1312309-64-0
Properties
Computed structural propertiesFilling in
- XLogP
- -0.2
- Topological polar surface area
- 96.5 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 8
- Rotatable bonds
- 11
- Heavy atoms
- 21
- Formal charge
- 0
- Complexity
- 418
Physicochemical properties
- storage temp.
- -20 °C · Storage temp. -20°C
- solubility
- Soluble in DMSO, DMF, DCM
- form
- Liquid
- color
- Colorless to light yellow
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302+H312+H332-H315-H319-H335
- Precautionary statements
- 260 · P260-P280-P301+P310
- HS Code
- 2942000090 · 2942000090
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- hs_code
- 2942000090
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H302+H312+H332-H315-H319-H335
- Precautionary statements
- P260-P280-P301+P310
Chemistry & industry
Applications
DescriptionAzido-PEG2-NHS ester is a click chemistry crosslinker containing an azide group and an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.
UsesN3-PEG2-C2-NHS ester is a nonclaevable 2-unit PEG linker used in the synthesis of antibody-drug conjugates (ADCs). N3-PEG2-C2-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Related reactions
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Compound notes
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