Azido-PEG5-PFP ester
Completing data — refresh the page later to see the latest
Basic information
- CAS
1818294-48-2- Standard SMILES
[N-]=[N+]=NCCOCCOCCOCCOCCOCCC(=O)Oc1c(F)c(F)c(F)c(F)c1F- InChIKey
YSQIHRPBWCEUAX-UHFFFAOYSA-N- Molecular formula
- C19H24F5N3O7
- Average molar mass
- 501.4 g/mol
Names & identifiers
- Preferred name
- Azido-PEG5-PFP ester
- IUPAC
- (2,3,4,5,6-pentafluorophenyl) 3-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]propanoate
- English name
- Azido-PEG5-PFP ester
- Molecular formula
- C19H24F5N3O7
- Molecular weight
- 501.41
Names & synonyms
Azido-PEG5-PFP ester1818294-48-2MFCD26793782(2,3,4,5,6-pentafluorophenyl) 3-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]propanoateperfluorophenyl 1-azido-3,6,9,12,15-pentaoxaoctadecan-18-oate2,3,4,5,6-PENTAFLUOROPHENYL 1-AZIDO-3,6,9,12,15-PENTAOXAOCTADECAN-18-OATEN3-PEG5-CH2CH2COOPFPorb1989479SCHEMBL21090258Azido-PEG5-perfluorophenyl esterC19H24F5N3O7AKOS040741264
Show more names
BP-21863DA-71233HY-130420CS-0107688G92604T14463
Database identifiers
- CAS
1818294-48-2
Properties
Computed structural propertiesFilling in
- XLogP
- 2.3
- Topological polar surface area
- 86.8 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 14
- Rotatable bonds
- 20
- Heavy atoms
- 34
- Formal charge
- 0
- Complexity
- 591
Chemistry & industry
Applications
DescriptionAzido-PEG5-PFP ester is a linker compound containing azide and PFP ester moities. The azide can participate in Click Chemistry reactions with alkynes, DBCO and BCN to form triazole groups. The PFP ester is amine-reactive and is less susceptible toward hydrolysis compared to NHS ester.
UsesAzido-PEG5-PFP ester is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs[1]. Azido-PEG5-PFP ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Related reactions
0 records
No reaction records under the current filter.
Compound notes
Loading…