Biotin-PEG2-C6-Azide
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Basic information
- CAS
1011268-29-3- Standard SMILES
[N-]=[N+]=NCCCCCC(=O)NCCOCCOCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21- InChIKey
NYAZUAAGKILBHO-WFXMLNOXSA-N- Molecular formula
- C22H39N7O5S
- Average molar mass
- 513.7 g/mol
- Monoisotopic mass
- 513.27333854
Names & identifiers
- Preferred name
- Biotin-PEG2-C6-Azide
- IUPAC
- N-[2-[2-[2-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]ethoxy]ethoxy]ethyl]-6-azidohexanamide
- English name
- Biotin-PEG2-C6-Azide
- Molecular formula
- C22H39N7O5S
- Molecular weight
- 513.66
Names & synonyms
Biotin-PEG2-C6-Azide1011268-29-36-azido-N-(2-(2-(2-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)ethoxy)ethoxy)ethyl)hexanamideMFCD28505538N-[2-[2-[2-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]ethoxy]ethoxy]ethyl]-6-azidohexanamideorb2279272SCHEMBL30403099AKOS040741344BP-22694DA-51141MS-29538HY-117042
Show more names
Biotin-PEG2-C6-N3Biotin-PEG8-C6-Azide
CS-0063565T14585F986900
Database identifiers
- CAS
1011268-29-3- PubChem CID
- 91757768
Properties
Computed structural propertiesFilling in
- XLogP
- 1
- Topological polar surface area
- 157 Ų
- Hydrogen bond donors
- 4
- Hydrogen bond acceptors
- 8
- Rotatable bonds
- 20
- Heavy atoms
- 35
- Formal charge
- 0
- Complexity
- 708
Physicochemical properties
- storage temp.
- 2 · Storage temp. 2-8°C
- form
- Solid
- color
- White to off-white
Chemistry & industry
Applications
DescriptionBiotin-PEG2-C6-azide is PEG linker containing a biotin group and an azide group. The azide group can react with either alkyne moiety in Cu(I)-catalyzed Click Chemistry reaction or DBCO moiety in copper-free Click Chemistry reaction to form a stable triazole linkage. The spacer arm helps to minimize steric hindrance involved with the binding to avidin molecules.
UsesBiotin-PEG2-C6-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTAC. Biotin-PEG2-C6-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Related reactions
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Compound notes
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