3-cyclohexyl-10-methyl-2-phenylpyrimido[4,5-b]quinoline-4,5(3H,10H)-dione
Basic information
- CAS
883956-47-6- Standard SMILES
Cn1c2ccccc2c(=O)c2c(=O)n(C3CCCCC3)c(-c3ccccc3)nc21- InChIKey
VMNOIZKDWKJSPW-UHFFFAOYSA-N- Molecular formula
- C24H23N3O2
- Average molar mass
- 385.5 g/mol
Names & identifiers
- Preferred name
- 3-cyclohexyl-10-methyl-2-phenylpyrimido[4,5-b]quinoline-4,5(3H,10H)-dione
- IUPAC
- 3-cyclohexyl-10-methyl-2-phenylpyrimido[4,5-b]quinoline-4,5-dione
- English name
- 3-cyclohexyl-10-methyl-2-phenylpyrimido[4,5-b]quinoline-4,5-dione
- Molecular formula
- C24H23N3O2
- Molecular weight
- 385.46
Names & synonyms
SRI-37240883956-47-63-cyclohexyl-10-methyl-2-phenylpyrimido[4,5-b]quinoline-4,5(3H,10H)-dioneorb1688334orb2900816SCHEMBL157970023-cyclohexyl-10-methyl-2-phenylpyrimido[4,5-b]quinoline-4,5-dioneSTK715416AKOS002374644DA-67755HY-150089CS-0608644
Show more names
Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 3-cyclohexyl-10-methyl-2-phenyl-
T61702
Database identifiers
- CAS
883956-47-6
Properties
Computed structural properties
- XLogP
- 4.5
- Topological polar surface area
- 53 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 2
- Heavy atoms
- 29
- Formal charge
- 0
- Complexity
- 743
Physicochemical properties
- storage temp.
- -20 °C · Store at -20°C
- solubility
- 11.36 mg/mL · DMSO : 11.36 mg/mL (29.47 mM; ultrasonic and warming and heat to 60°C)
- form
- Solid
- color
- White to light yellow
Chemistry & industry
Applications
UsesSRI-37240 is a potent premature termination codons (PTCs) inhibitor. SRI-37240 suppresses CFTR nonsense mutations. SRI-37240 alters cellular translation termination at PTCs in HEK293T cells. SRI-37240 can also restore CFTR function in primary bronchial epithelial cells when combination with G418[1].
Related reactions
0 records
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Compound notes
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