SEC inhibitor KL-2
Basic information
- CAS
900308-51-2- Standard SMILES
Cc1ccc(Cl)cc1NC(=O)/C(O)=C/C(=O)c1ccc(F)cc1- InChIKey
UTMIAXADLSTQRD-UHFFFAOYSA-N- Molecular formula
- C17H13ClFNO3
- Average molar mass
- 333.74 g/mol
Names & identifiers
- Preferred name
- SEC inhibitor KL-2
- English name
- SEC inhibitor KL-2
- Molecular formula
- C17H13ClFNO3
- Molecular weight
- 333.74
Names & synonyms
KL2KL-2KL 2SEC inhibitor KL-2, 10 mM in DMSON-(5-Chloro-2-methylphenyl)-4-(4-fluorophenyl)-2-hydroxy-4-oxobut-2-enamide2-Butenamide, N-(5-chloro-2-methylphenyl)-4-(4-fluorophenyl)-2-hydroxy-4-oxo-
Database identifiers
- CAS
900308-51-2
Properties
Physicochemical properties
- Boiling point
- 521.1 · 521.1±50.0 °C(Predicted)
- Density
- 1.4 · 1.400±0.06 g/cm3(Predicted)
- storage temp.
- -20 °C · Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 8.09 · 8.09±0.50(Predicted)
- form
- Solid
- color
- Light yellow to yellow
- SMILES
- CC1=CC=C(Cl)C=C1NC(/C(O)=C/C(C2=CC=C(F)C=C2)=O)=O
- UNSPSC Code
- 12352200 · 12352200
- NACRES
- 77 · NA.77
- WGK Germany
- 3 · WGK 3
- Storage Class
- 11 · 11 - Combustible Solids
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- wgk
- WGK 3
- Storage Class
- 11 - Combustible Solids
Chemistry & industry
Applications
UsesSEC inhibitor KL-2 (KL-2), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-2 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 1.50 μM[1].
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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