Basic information
- CAS
220701-06-4- Standard SMILES
C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(N)=O- InChIKey
SAWVPDQXSCHRKB-UZTPZCRESA-N- Molecular formula
- C33H43N7O9
- Average molar mass
- 681.7 g/mol
Names & identifiers
- Preferred name
- Fmoc-Ala-Glu-Asn-Lys-NH2
- IUPAC
- (4S)-5-[[(2S)-4-amino-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-4-[[(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoyl]amino]-5-oxopentanoic acid
- English name
- L-Lysinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-L-α-glutamyl-L-asparaginyl- (9CI)
- Molecular formula
- C33H43N7O9
- Molecular weight
- 681.75
Names & synonyms
Fmoc-Ala-Glu-Asn-Lys-NH2220701-06-4AKOS040756234MS-31095HY-114174CS-0078435G17225(4S)-5-[[(2S)-4-amino-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-4-[[(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoyl]amino]-5-oxopentanoic acidFmoc-AENK-NH2L-Lysinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-L-α-glutamyl-L-asparaginyl- (9CI)
Database identifiers
- CAS
220701-06-4
Properties
Computed structural properties
- XLogP
- -2.9
- Topological polar surface area
- 275 Ų
- Hydrogen bond donors
- 8
- Hydrogen bond acceptors
- 10
- Rotatable bonds
- 20
- Heavy atoms
- 49
- Formal charge
- 0
- Complexity
- 1,180
Physicochemical properties
- Boiling point
- 1151.3 · 1151.3±65.0 °C(Predicted)
- Density
- 1.324 · 1.324±0.06 g/cm3(Predicted)
- storage temp.
- -20 °C, · -20°C, protect from light, stored under nitrogen
- solubility
- 100 mg/mL · DMSO: 100 mg/mL (146.68 mM; ultrasonic and warming and heat to 80°C)
- form
- Solid
- pka
- 4.44 · 4.44±0.10(Predicted)
- color
- White to off-white
Chemistry & industry
Applications
UsesFmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing[1].
Suppliers24 total
Aladdin Scientific[email protected]
上海鸿肽生物科技有限公司15318089928 · [email protected]
中科华药(江苏)生物科技有限公司18020125070 · [email protected]
杭州思诺达医药科技有限责任公司0571-87213919 17306812703 · [email protected]
Zhejiang J&C Biological Technology Co.,Limited+1-2135480471 · [email protected]
太原百利恒康生物技术有限公司19135651983 · [email protected]
宝鸡缔都医药化工有限公司029-81145305 17791533577 · [email protected]
康明永瑞生物科技（苏州）有限公司17751201929; 17751201929 · [email protected]
天津普西唐生物医药科技有限公司010-60605840 · [email protected]
BOC Sciences16314854226; +8616314854226 · [email protected]
杭州贝普泰生物医药有限公司0571-85350119 13305819357 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
Loading…