Basic information
- CAS
848057-98-7- Standard SMILES
Cc1ccc(C(=O)Nc2cc(C(F)(F)F)ccc2N2CCOCC2)o1- InChIKey
FZCPNRVICXFZJR-UHFFFAOYSA-N- Molecular formula
- C17H17F3N2O3
- Average molar mass
- 354.32 g/mol
Names & identifiers
- Preferred name
- 5-methyl-N-[2-(morpholin-4-yl)-5-(trifluoromethyl)phenyl]furan-2-carboxamide
- IUPAC
- 5-methyl-N-[2-morpholin-4-yl-5-(trifluoromethyl)phenyl]furan-2-carboxamide
- English name
- SPHINX
- Molecular formula
- C17H17F3N2O3
- Molecular weight
- 354.32
Names & synonyms
848057-98-75-methyl-N-(2-morpholino-5-(trifluoromethyl)phenyl)furan-2-carboxamide5-methyl-N-[2-(morpholin-4-yl)-5-(trifluoromethyl)phenyl]furan-2-carboxamide5-methyl-N-[2-morpholin-4-yl-5-(trifluoromethyl)phenyl]furan-2-carboxamideWAY-6528485-methyl-N-[2-morpholino-5-(trifluoromethyl)phenyl]furan-2-carboxamideorb1298819CHEMBL5184609SCHEMBL15648757FZCPNRVICXFZJR-UHFFFAOYSA-NUS9695160, SPHINXBDBM221070
Show more names
SPHINXSPHINX, 10 mM in DMSO2-Furancarboxamide, 5-methyl-N-[2-(4-morpholinyl)-5-(trifluoromethyl)phenyl]-phosphorylation,mice,Inhibitor,AMD,SRPK,Serine-arginine protein kinases,small molecule,SPHINX,scaffold,GAPDH,rat,inhibit,EGF,SRSF,VEGF
GLXC-20266EBC-00606MFCD07315693AKOS001099848DA-49864MS-25511HY-132126CS-0148722
Database identifiers
- CAS
848057-98-7- ChEMBL
CHEMBL5184609
Properties
Computed structural properties
- XLogP
- 3.2
- Topological polar surface area
- 54.7 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 7
- Rotatable bonds
- 3
- Heavy atoms
- 25
- Formal charge
- 0
- Complexity
- 469
Physicochemical properties
- Boiling point
- 391.2 · 391.2±42.0 °C(Predicted)
- Density
- 1.341 · 1.341±0.06 g/cm3(Predicted)
- storage temp.
- -20 °C · Store at -20°C
- solubility
- 50 mg/mL · DMSO : 50 mg/mL (141.12 mM; ultrasonic and warming and heat to 60°C)
- pka
- 12.09 · 12.09±0.70(Predicted)
- form
- Solid
- color
- Off-white to light yellow
Chemistry & industry
Applications
UsesSPHINX is a selective SRPK1 inhibitor with an IC50 value of 0.58 μM. SPHINX effectively reduces Choroidal Neovascularization (CNV) in vivo. SPHINX can be used for the research of (age-related macular degenaration) AMD[1].
Suppliers18 total
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
江苏艾康生物医药研发有限公司025-025-66113011 15955137747 · [email protected]
銳迪國際科技有限公司18024082417 · [email protected]
天津普西唐生物医药科技有限公司010-60605840 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
浙江珲达生物科技有限公司0571-89903022 18679456698 · [email protected]
上海阿拉丁生化科技股份有限公司6206333 13167063860 · [email protected]
上海源叶生物科技有限公司18916372613 · [email protected]
常州合晶化工有限公司85528066 13775048983 · [email protected]
天津凯利奇生物科技有限公司15076683720 · [email protected]
上海超岚化工科技中心QQ：65489617 13301690235 · [email protected]
安徽凯泽合联医药科技有限公司18130062233 · [email protected]
ATK CHEMICAL COMPANY LIMITED+undefined-21-51877795 · [email protected]
Aladdin Scientific[email protected]
TargetMol中国（陶术生物）4008200310 15002144251 · [email protected]
上海一飞生物科技有限公司021-65675885 18964387627 · [email protected]
上海捷世凯生物科技有限公司021-57520305 13795461237 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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