Corazonin
Basic information
- CAS
122929-08-2- Standard SMILES
C[C@@H](O)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(N)=O- InChIKey
UOABGUNWRLWTJU-YPKDOBRCSA-N- Molecular formula
- C62H84N18O18
- Average molar mass
- 1,369.4 g/mol
Overview
Corazonin has been reported in Periplaneta americana with data available.
Names & identifiers
- Preferred name
- Corazonin
- IUPAC
- (2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S,3R)-1-[[(2S)-1,4-diamino-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-2-[[(2S)-2-[[(2S,3R)-3-hydroxy-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]butanoyl]amino]-3-phenylpropanoyl]amino]pentanediamide
- English name
- CORAZONIN
- Molecular formula
- C62H84N18O18
- Molecular weight
- 1369.44
Names & synonyms
122929-08-2CorazoninL-Aspartamide, 5-oxo-L-prolyl-L-threonyl-L-phenylalanyl-L-glutaminyl-L-tyrosyl-L-seryl-L-arginylglycyl-L-tryptophyl-L-threonyl-5-Oxo-L-prolyl-L-threonyl-L-phenylalanyl-L-glutaminyl-L-tyrosyl-L-seryl-L-arginylglycyl-L-tryptophyl-L-threonyl-L-aspartamideCorazonin Pyr-Thr-Phe-Gln-Tyr-Ser-Arg-Gly-Trp-Thr-Asn-NH2orb1981276SCHEMBL29579465C62H84N18O18MFCD00133199AS-76818FC110272C5768
Show more names
[Arg7]-CorazoninPYR-TFQYSRGWTN-NH2CORAZONIN,CORAZONICORAZONIN USP/EP/BPCorazonin, ≥97% (HPLC)Corazonin (Bombyx mori)Black-inducing neuropeptideCorazonin (Neobellieria bullata)CORAZONIN (PERIPLANETA AMERICANA)
A11962T76183
Properties
Computed structural properties
- XLogP
- -6
- Topological polar surface area
- 610 Ų
- Hydrogen bond donors
- 21
- Hydrogen bond acceptors
- 19
- Rotatable bonds
- 39
- Heavy atoms
- 98
- Formal charge
- 0
- Complexity
- 2,840
Physicochemical properties
- Density
- 1.56 · 1.56±0.1 g/cm3(Predicted)
- storage temp.
- 20 °C · −20°C
- pka
- 9.82 · 9.82±0.15(Predicted)
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302-H315-H319-H335
- Precautionary statements
- 280 · P280-P305+P351+P338
- WGK Germany
- 3 · 3
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- wgk
- 3
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P280-P305+P351+P338
Chemistry & industry
Applications
DescriptionA highly conserved neuropeptide produced by the central nervous system in insects, crustaceans, and ticks, CRZ has been implicated in controlling different species- and stage-specific functions.
UsesCorazonin is a highly conserved neuropeptide hormone of wide-spread occurrence in insects, serves a central regulator of caste identity and behavior in social insects. Corazonin is also preferentially expressed in workers and/or foragers from other social insect species[1][2].
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Compound notes
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