Basic information
- CAS
348079-12-9- Standard SMILES
CC(=O)OCOC(=O)CN(CC(=O)OCOC(C)=O)c1cc2oc(-c3ncc(C(=O)OCOC(C)=O)o3)cc2cc1OCCOc1c(N(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O)ccc(F)c1F- InChIKey
FPUWXSBNYDMTRN-UHFFFAOYSA-N- Molecular formula
- C43H43F2N3O24
- Average molar mass
- 1,023.8 g/mol
Names & identifiers
- Preferred name
- Acetyloxymethyl 2-[6-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]-5-[2-[6-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]-2,3-difluorophenoxy]ethoxy]-1-benzofuran-2-yl]-1,3-oxazole-5-carboxylate
- IUPAC
- acetyloxymethyl 2-[6-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]-5-[2-[6-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]-2,3-difluorophenoxy]ethoxy]-1-benzofuran-2-yl]-1,3-oxazole-5-carboxylate
- English name
- FURA-FF, AM
- Molecular formula
- C43H43F2N3O24
- Molecular weight
- 1023.8
Names & synonyms
348079-12-9Fura-FF AMFURA-FF, AMacetyloxymethyl 2-[6-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]-5-[2-[6-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]-2,3-difluorophenoxy]ethoxy]-1-benzofuran-2-yl]-1,3-oxazole-5-carboxylate2-[6-[Bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]-5-[2-[6-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]-2,3-difluorophenoxy]ethoxy]-2-benzofuranyl]-5-oxazolecarboxylic acid(acetyloxy)methyl esterFura-FF Acetoxymethyl esterFura-FF,AMorb1984937AKOS040756026HY-130575CS-0109218T37762
Show more names
Fura-FF, AM [Fura-2FF, AM] *CAS 348079-12-9*5-Oxazolecarboxylic acid, 2-[6-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]-5-[2-[6-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]-2,3-difluorophenoxy]ethoxy]-2-benzofuranyl]-, (acetyloxy)methyl ester
Properties
Computed structural properties
- XLogP
- 4.3
- Topological polar surface area
- 327 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 29
- Rotatable bonds
- 37
- Heavy atoms
- 72
- Formal charge
- 0
- Complexity
- 1,830
Physicochemical properties
- Boiling point
- 971.5 · 971.5±75.0 °C(Predicted)
- Density
- 1.447 · 1.447±0.06 g/cm3(Predicted)
- storage temp.
- -20 °C · Store at -20°C
- solubility
- DMSO: soluble
- form
- A solid
- pka
- 0.36 · 0.36±0.50(Predicted)
- color
- Light yellow to yellow
Chemistry & industry
Applications
DescriptionFura-FF AM is a cell-permeable acetoxymethyl ester of the fluorescence calcium indicator fura-FF (potassium salt) . As fura-FF AM enters cells, it is hydrolyzed by intracellular esterases to produce fura-FF. Fura-FF is a difluorinated derivative of the calcium indicator fura-2 . Unlike, fura-2, fura-FF has negligible magnesium sensitivity, thus reducing interference from this cation.1 Fura-FF also has a higher calcium dissociation constant than fura-2 (Kd(calcium) = 6 and 0.14 μM, respectively).1,2 However, the spectral properties of fura-FF and fura-2 are similar with fura-FF displaying excitation/emission spectra of 365/514 nm in the absence of calcium, with a shift to 339/507 nm in the presence of a high calcium concentration.3 Low affinity calcium dyes, including fura-FF, are preferred for studying compartments with high concentrations of calcium, such as mitochondria, or in cell systems that have relatively low calcium buffering capacities, such as neuronal dendrites and spines.4,5,6
UsesFura-FF AM is a cell-permeable acetoxymethyl ester of fura-FF, a dluorescent calcium indicator. Fura-FF AM is hydrolyzed by intracellular esterases to release fura-FF in cells. Fura-FF is a difluorinated derivative of the calcium indicator fura-2. Compared to fura-2, fura-FF has a low affinity for calcium and is suitable for studying compartments with high concentrations of calcium.
Suppliers10 total
MedBio脉铂医药021-69568360 18916172912 · [email protected]
上海一研生物科技有限公司021-69985186 13611928337 · [email protected]
西安百萤生物科技有限公司029-029-68064558 18502920169 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
爱必信（上海）生物科技有限公司13761418683 · [email protected]
Related reactions
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Compound notes
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