Basic information
- CAS
3033-77-0- Standard SMILES
C[N+](C)(C)CC1CO1.[Cl-]- InChIKey
PUVAFTRIIUSGLK-UHFFFAOYSA-M- Molecular formula
- C6H14NO.Cl
- Average molar mass
- 151.63 g/mol
- Monoisotopic mass
- 151.0763918
Names & identifiers
- Preferred name
- Glycidyltrimethylammonium chloride
- IUPAC
- trimethyl(oxiran-2-ylmethyl)azanium chloride
- English name
- 2,3-Epoxypropyltrimethylammonium chloride
- Molecular formula
- C6H14ClNO
- Molecular weight
- 151.63
Names & synonyms
3033-77-02,3-Epoxypropyltrimethylammonium chlorideGLYCIDYLTRIMETHYLAMMONIUM CHLORIDE(2,3-Epoxypropyl)trimethylammonium chlorideGlycidyl trimethylammonium chlorideGlytac A 100G-MACOxiranemethanaminium, N,N,N-trimethyl-, chlorideTrimethylglycidylammonium chloride1-(Trimethylammonio)-2,3-epoxypropane chlorideN-Glycidyl-N,N,N-trimethylammonium chlorideDTXSID1044643
Show more names
EPTACN,N,N-trimethyl-1-(oxiran-2-yl)methanaminium chlorideglytacGlytac Aglytaca100UNII:283XH39M8XRefametinib Impurity 10Glycidyltrimethylaminium
Ammonium, (2,3-epoxypropyl)trimethyl-, chlorideN,N,N-Trimethyloxiranemethanaminium chloride283XH39M8XNSC-512132-Oxiranemethanaminium, N,N,N-trimethyl-, chloride (1:1)DTXCID9024643glycidyl trimethyl ammonium chlorideEPTMAC
Database identifiers
- CAS
3033-77-0- PubChem CID
- 18205
- DTXSID
DTXSID1044643- ChEMBL
CHEMBL3187272- UNII
- 283XH39M8X
- EC Number
- 221-221-0
Properties
Computed structural properties
- Topological polar surface area
- 12.5 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 2
- Heavy atoms
- 9
- Formal charge
- 0
- Complexity
- 85
Experimental & physicochemical properties
Chemical ClassesNitrogen Compounds -> Quaternary Amines
Density1.1 g/cm³
SolubilitySolubility in water: miscible
Food Contact Substances
FCS -> FDA Cumulative Estimated Daily Intake (CEDI)
FCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR
FCS -> FDA Inventory of Effective Food Contact Substance (FCS) Notifications
FCS -> FDA Inventory of Effective Food Contact Substance (FCS) Notifications
FCS -> FDA Inventory of Effective Food Contact Substance (FCS) Notifications
FCS -> FDA Inventory of Effective Food Contact Substance (FCS) Notifications
Physical Description
Liquid
COLOURLESS-TO-LIGHT-YELLOW CLEAR ODOURLESS LIQUID.
Physicochemical properties
- Melting point
- 137 · 137-139 °C
- Density
- 1.13 g/mL · 1.13 g/mL at 20 °C(lit.)
- refractive index
- 1.48 · 1.48
- Flash point
- 170 °C · 170 °C
- storage temp.
- 2 · 2-8°C
- solubility
- Methanol (Slightly), Water (Sparingly)
- form
- Oil
- color
- Colourless
- Water Solubility
- 852 g/L · 852g/L at 20℃
- BRN
- 3914931 · 3914931
- Stability
- Stable. Incompatible with oxidizing agents
- InChI
- InChI=1S/C6H14NO.ClH/c1-7(2,3)4-6-5-8-6;/h6H,4-5H2,1-3H3;1H/q+1;/p-1
- InChIKey
- PUVAFTRIIUSGLK-UHFFFAOYSA-M
- SMILES
- [N+](C)(C)(C)CC1OC1.[Cl-]
- Indirect Additives used in Food Contact Substances
- 2 · 2,3-EPOXYPROPYLTRIMETHYLAMMONIUM CHLORIDE
- CAS DataBase Reference
- 3033 · 3033-77-0(CAS DataBase Reference)
- FDA 21 CFR
- 178.352 · 178.3520
- FDA UNII
- 283 XH39M8X · 283XH39M8X
- EPA Substance Registry System
- Glycidyltrimethylammonium chloride (3033-77-0)
- UNSPSC Code
- 12352302 · 12352302
- NACRES
- 22 · NA.22
- Symbol(GHS)
- 5 · GHS05,GHS07,GHS08
- Signal word
- Danger
- Hazard statements
- 302 · H302+H312-H317-H318-H341-H350-H360F-H373-H412
- Precautionary statements
- 201 · P201-P273-P280-P302+P352+P312-P305+P351+P338+P310-P308+P313
- target organs
- Kidney
- PPE
- 3 · Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
- Hazard Codes
- T
- Risk Statements
- 45 · 45-21/22-41-43-48/22-68-52/53-20/21/22-60
- Safety Statements
- 53 · 53-14-26-36/37/39-45-61
- WGK Germany
- 3 · 3
- RTECS
- 3480000 · BQ3480000
- TSCA
- TSCA listed
- HS Code
- 29239000 · 29239000
- Storage Class
- 6.1 C · 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
- Hazard Classifications
- 4 DermalAcute · Acute Tox. 4 DermalAcute Tox. 4 InhalationAcute Tox. 4 OralAquatic Chronic 3Carc. 1BEye Dam. 1Muta. 2Repr. 1BSkin Sens. 1STOT RE 2STOT SE 2
- REACH Registrations
- Active
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Danger
H302: Harmful if swallowed [Warning Acute toxicity, oral]
P203, P260, P261, P264, P264+P265, P270, P272, P273, P280, P301+P317, P302+P352, P305+P354+P338, P317, P318, P319, P321, P330, P333+P317, P362+P364, P405, and P501 (click each P-code to see the statement)
Danger
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P203, P260, P261, P264, P264+P265, P270, P272, P273, P280, P301+P317, P302+P352, P305+P354+P338, P317, P318, P319, P321, P330, P333+P317, P362+P364, P405, and P501 (click each P-code to see the statement)
Hazard information
Regulatory Information
Chemical: Oxiranemethanaminium, N,N,N-trimethyl-, chloride
Hazard Traits - Carcinogenicity
2-Oxiranemethanaminium, N,N,N-trimethyl-, chloride (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 2-Oxiranemethanaminium, N,N,N-trimethyl-, chloride (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
REACH registered substance: 2,3-epoxypropyltrimethylammonium chloride (EC: 221-221-0)
Other Safety InformationIMAP assessments - Oxiranemethanaminium, N,N,N-trimethyl-, chloride: Environment tier I assessment
Fire HazardsNot combustible. Gives off irritating or toxic fumes (or gases) in a fire. Risk of fire and explosion as a result of decomposition when heated.
Hazards Summary
Allergic contact dermatitis reported in pulp and paper workers; [Kanerva, p. 1793] May cause skin sensitization; May have effects on the kidneys and reproductive system; Probably carcinogenic to humans; [ICSC] A skin and eye irritant; [ChemIDplus] See Benzalkonium chloride.
Chemical DangersDecomposes above 35 °C . This produces toxic and corrosive fumes. This generates fire or explosion hazard.
Hazard Classes and Categories
Acute Tox. 4 (100%)
Acute toxicity - category 4
Carc. 1B
Safety & protection
Fire FightingIn case of fire in the surroundings, use appropriate extinguishing media. In case of fire: keep drums, etc., cool by spraying with water.
First Aid Measures
Fresh air, rest.
Remove contaminated clothes. Rinse and then wash skin with water and soap.
Rinse with plenty of water for several minutes (remove contact lenses if easily possible). Refer immediately for medical attention.
Rinse mouth. Refer for medical attention .
Safe StorageCool. Store in an area without drain or sewer access.
Spillage Disposal
Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
Eye PreventionWear safety goggles or face shield.
Inhalation RiskEvaporation at 20 °C is negligible; a harmful concentration of airborne particles can, however, be reached quickly on spraying.
Skin PreventionProtective gloves. Protective clothing.
Exposure PreventionSee EFFECTS OF LONG-TERM OR REPEATED EXPOSURE. AVOID ALL CONTACT!
Ingestion PreventionDo not eat, drink, or smoke during work.
Inhalation PreventionUse closed system or ventilation.
Effects of Long Term ExposureRepeated or prolonged contact may cause skin sensitization. The substance may have effects on the kidneys. Animal tests show that this substance possibly causes toxicity to human reproduction or development.
Effects of Short Term ExposureThe substance is severely irritating to the eyes and respiratory tract.
Toxicology
Adverse EffectsSkin Sensitizer - An agent that can induce an allergic reaction in the skin.
Exposure RoutesThe substance can be absorbed into the body in hazardous amounts through the skin, by inhalation of its aerosol and by ingestion.
Signs and Symptoms
Sore throat. Cough.
Redness. Pain. Burns.
Sore throat. Abdominal pain.
ICSC Environmental DataThe substance is harmful to aquatic organisms. The substance may cause long-term effects in the aquatic environment. It is strongly advised not to let the chemical enter into the environment.
Safety data
- PPE
- Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
- wgk
- 3
- tsca
- TSCA listed
- rtecs
- BQ3480000
- hs_code
- 29239000
- risk_code
- 45-21/22-41-43-48/22-68-52/53-20/21/22-60
- Signal word
- Danger
- Symbol(GHS)
- GHS05,GHS07,GHS08
- hazard_code
- T
- safety_code
- 53-14-26-36/37/39-45-61
- Storage Class
- 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
- target organs
- Kidney
- Hazard statements
- H302+H312-H317-H318-H341-H350-H360F-H373-H412
- REACH Registrations
- Active
- Hazard Classifications
- Acute Tox. 4 DermalAcute Tox. 4 InhalationAcute Tox. 4 OralAquatic Chronic 3Carc. 1BEye Dam. 1Muta. 2Repr. 1BSkin Sens. 1STOT RE 2STOT SE 2
- Precautionary statements
- P201-P273-P280-P302+P352+P312-P305+P351+P338+P310-P308+P313
Chemistry & industry
Uses & manufacturing
Uses
Used in paper manufacturing; [Kanerva, p. 1793] The quarternary ammonium compounds are cationic surfactants and antimicrobial cleansers; [Marks, p. 265]
Pulp and Paper Processing [Category: Industry]
U.S. Production2023: 1,000,000 - <5,000,000 lb
Industry UsesProcessing aids not otherwise specified
General Manufacturing Information
All Other Chemical Product and Preparation Manufacturing
2-Oxiranemethanaminium, N,N,N-trimethyl-, chloride (1:1): ACTIVE
Applications
DescriptionUsed in the production of cationic starch for the paper industry, 2,3-Epoxypropyl trimethyl ammonium chloride (EPTMAC) caused contact dermatitis in the workers.
UsesReagent used for synthesis and antimicrobial activity of a water soluble chitosan derivative with a fiber-reactive group.
UsesGlycidyltrimethylammonium chloride be used as a derivatizing agent to synthesize N-(2-hydroxypropyl)-3-trimethylammonium chitosan chloride (HTCC), a water-soluble chitosan derivative, by reacting with chitosan. HTCC can form nanocomposite films with silver nanoparticles that show good antimicrobial property and optical transparency. Cationic starches can also be prepared by derivatization of starch with GTMAC.
General DescriptionGlycidyltrimethylammonium chloride (GTMAC) is a cationizing agent commonly used for starch modification.
Suppliers100 total
国药集团化学试剂有限公司86-21-63210123 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
淄博泰立泽化工有限公司0533-5200592 13173271895 · [email protected]
Shandong chuangyingchemical Co., Ltd.18853181302 · [email protected]
合肥翰刚医药科技有限公司+8618062405514 · [email protected]
武汉欣扬瑞和化学科技有限公司153-07155313 15307155313 · [email protected]
河北创海生物科技有限公司+86-86-13131129325 · [email protected]
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]
上海弘顺生物科技有限公司15901914505 · [email protected]
上海将来实业股份有限公司400-0066400 13621662912 · [email protected]
安耐吉化学&3A（安徽泽升科技股份有限公司）400-0056266 · [email protected]
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武汉丰泰威远科技有限公司027-87465837 19945049750 · [email protected]
山东西亚化学有限公司13355009207 13355009207 · [email protected]
HONG KONG IPURE BIOLOGY CO.,LIMITED86 18062405514 18062405514 · [email protected]
四川库利南科技有限公司400-1166-196 18981987031 · [email protected]
深圳市飞鸣科技有限公司0755-85232577 · [email protected]
天津希恩思生化科技有限公司400 638 7771 · [email protected]
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TOKYO CHEMICAL INDUSTRY CO., LTD.03-36680489 · [email protected]
TCI Europe320-37350700 · [email protected]
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武汉普洛夫生物科技有限公司17612776928 · [email protected]
北京环宇世纪化学科技有限公司hysj_bj.com
深圳菲斯生物科技有限公司0755-83725350 13380397412 · [email protected]
上海将来实业股份有限公司400-0066400 13621662912 · [email protected]
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成都零六生物科技有限公司400-1166-196 13458535857 · [email protected]
上海麦克林生化科技股份有限公司15221275939 15221275939 · [email protected]
杭州杰恒化工有限公司0571-87396432 · [email protected]
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池州凯隆进出口贸易有限公司[email protected]
Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司021-61415566 800-8193336 · [email protected]
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湖北军瑞生物科技有限公司13971166412 · [email protected]
武汉鑫儒化工有限公司15927387915 15337108568 · [email protected]
厦门志信化学有限公司+86-5922680277 +86-13806087780 · [email protected]
Alfa Chemistry+1-5166625404 · [email protected]
成都润泽本土化工有限公司028-88469284 18000562381 · [email protected]
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广东翁江化学试剂有限公司0751-2886750 13927877953 · [email protected]
Related reactions
3 records
Compound notes
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