Basic information
- CAS
3055-95-6- Standard SMILES
CCCCCCCCCCCCOCCOCCOCCOCCOCCO- InChIKey
LAPRIVJANDLWOK-UHFFFAOYSA-N- Molecular formula
- C22H46O6
- Average molar mass
- 406.6 g/mol
- Monoisotopic mass
- 406.32943919
Overview
Laureth-5 is a hydroxypolyether that is pentaethylene glycol in which one of the terminal hydrogens is replaced by a dodecyl group. It has a role as a nonionic surfactant. It is a primary alcohol, a pentaethylene glycol and a hydroxypolyether.
Names & identifiers
- Preferred name
- 3,6,9,12,15-Pentaoxaheptacosan-1-ol
- IUPAC
- 2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethanol
- English name
- C12E5
- Molecular formula
- C22H46O6
- Molecular weight
- 406.6
Names & synonyms
3055-95-6Pentaethylene glycol monododecyl etherLaureth-53,6,9,12,15-PENTAOXAHEPTACOSAN-1-OLC12E5Pentaethylene glycol dodecyl etherPentaethylene glycol lauryl etherPentaoxyethylene monododecyl etherPEG-5 Lauryl ether2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethanolLauryl alcohol tetra(oxyethylene) ethanolPentaethylene glycol mono-n-dodecyl ether
Show more names
n-dodecyl-PEG5-OHDODECYLPENTAGLYCOLDodecyloxy-PEG5-OHN-DODECYLPENTAOXYETHYLENEPOLYOXYETHYLENE 5 LAURYL ETHERpentaethyleneglycollauryletherpentaoxyethylenemonododecylether
Q9F4A7XYE8DTXSID1058632CHEBI:913232-(2-(2-(2-(2-dodecoxyethoxy)ethoxy)ethoxy)ethoxy)ethanolRefChem:7683SAFOL 23E5 ETHOXYLATEC12EO5DTXCID5032319
Database identifiers
- CAS
Properties
Computed structural properties
- XLogP
- 4.5
- Topological polar surface area
- 66.4 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 6
- Rotatable bonds
- 25
- Heavy atoms
- 28
- Formal charge
- 0
- Complexity
- 265
Experimental & physicochemical properties
Chemical ClassesOther Uses -> Emulsifiers/Surfactants
Cosmetics
Cosmetic ingredients (Laureth-5) -> CIR (Cosmetic Ingredient Review)
Emulsifying; Surfactant
SurfactantsSurfactant
Physical DescriptionHygroscopic liquid; [Sigma-Aldrich MSDS]
Physicochemical properties
- Melting point
- 14.5 · 14.5-15.0 °C
- Boiling point
- 207 · 207-210 °C(Press: 0.8 Torr)
- Density
- 0.963 g/mL · 0.963 g/mL at 20 °C(lit.)
- refractive index
- 1.446 · 1.446~1.452(35℃/D)
- Flash point
- 23 °C · 23 °C
- storage temp.
- 2 · 2-8°C
- pka
- 14.36 · 14.36±0.10(Predicted)
- form
- powder to lump to clear liquid
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Danger
H315 (98.6%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P332+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 69 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Danger
H302: Harmful if swallowed [Warning Acute toxicity, oral]
Hazard information
Regulatory Information
Chemical: 3,6,9,12,15-Pentaoxaheptacosan-1-ol
3,6,9,12,15-Pentaoxaheptacosan-1-ol: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Other Safety InformationIMAP assessments - Ethoxylates of aliphatic alcohols (>C6): Human health tier II assessment
Hazards SummaryCauses altered sleep time (including change in righting reflex), excitement, and ataxia in oral lethal-dose studies of mice (lethal dose > 508 mg/kg); [RTECS] A skin and strong eye irritant; [Sigma-Aldrich MSDS]
Hazard Classes and Categories
Skin Irrit. 2 (98.6%)
Acute toxicity (ingestion) - category 4
Toxicology
Toxicity Summary
The CIR Expert Panel concluded that the alkyl PEG ethers, listed below, are safe in the present practices of use and concentration described in this safety assessment when formulated to be nonirritating. This assessment is also intended to address future alkyl PEG ether cosmetic ingredients that vary from those ingredients recited herein only by the number of ethylene glycol repeat units...Laureth-5...
Chemistry & industry
Uses & manufacturing
Uses
CIR ingredient: Laureth-5
Non-ionic surfactant; [ChemIDplus]
Use ClassificationCosmetics -> Emulsifying; Surfactant
General Manufacturing Information3,6,9,12,15-Pentaoxaheptacosan-1-ol: ACTIVE
Applications
Uses<ul><li><strong>Coadsorption of a Monoclonal Antibody and Nonionic Surfactant at the SiO(2)/Water Interface:</strong> This study demonstrates the coadsorption properties of Pentaethylene glycol monododecyl ether with monoclonal antibodies, offering significant implications for biopharmaceutical formulations to improve drug stability and delivery (Lu et al., 2018).</li><li><strong>Water-Resistant Surface Modification of Hydrophobic Polymers with Water-Soluble Surfactant Additives:</strong> This research showcases the effectiveness of Pentaethylene glycol monododecyl ether in modifying hydrophobic polymer surfaces to make them water-resistant, pointing to its utility in various industrial and coating applications (Thompson et al., 2021).</li><li><strong>Synergistic Role of Temperature and Salinity in Aggregation of Nonionic Surfactant-Coated Silica Nanoparticles:</strong> Highlights the use of Pentaethylene glycol monododecyl ether in nanoparticle stabilization, particularly under varying thermal and saline conditions, beneficial for tailored drug delivery systems and environmental applications (Bharti et al., 2023).</li></ul>
Suppliers66 total
陕西缔都医药有限责任公司029-81124775 17791530730 · [email protected]
北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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