L-158809
Basic information
- CAS
133240-46-7- Standard SMILES
CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1- InChIKey
YFWXFHNZGKNDBC-UHFFFAOYSA-N- Molecular formula
- C24H23N7
- Average molar mass
- 409.5 g/mol
- Monoisotopic mass
- 409.20149376
Overview
RN & structure given in first source; angiotensin receptor antagonist
Names & identifiers
- Preferred name
- L-158809
- IUPAC
- 2-ethyl-5,7-dimethyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazo[4,5-b]pyridine
- English name
- 2-Ethyl-5,7-dimethyl-3-[2'-(1H-tetrazole-5-yl)biphenyl-4-ylmethyl]-3H-imidazo[4,5-b]pyridine
- Molecular formula
- C24H23N7
- Molecular weight
- 409.49
Names & synonyms
L 158809L-158809RefChem:924343135145-96-93H-imidazo(4,5-b)pyridine, 2-ethyl-5,7-dimethyl-3-(2'-(2H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)-608GM1WHMGL-158,809133240-46-72-Ethyl-5,7-dimethyl-3-((4-(2-(2H-tetrazol-5-yl)phenyl)phenyl)methyl)imidazo(4,5-b)pyridineCHEMBL75502-ethyl-5,7-dimethyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazo[4,5-b]pyridineYFWXFHNZGKNDBC-UHFFFAOYSA-N
Show more names
809L-158MSD L-1588092-Ethyl-5,7-dimethyl-3-[2'-(1H-tetrazole-5-yl)biphenyl-4-ylmethyl]-3H-imidazo[4,5-b]pyridine2-Ethyl-5,7-dimethyl-3-[[2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl]-3H-imidazo[4,5-b]pyridine3H-Imidazo[4,5-b]pyridine, 2-ethyl-5,7-dimethyl-3-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
[3H]L158809[3H]-L158809[3H]L-158,809SCHEMBL683357GTPL3939orb1703258SCHEMBL5344127SCHEMBL29486794
Database identifiers
- CAS
133240-46-7- PubChem CID
- 183134
- DTXSID
DTXSID00928018- ChEMBL
CHEMBL7550- Nikkaji
- J425.097D
Properties
Computed structural properties
- XLogP
- 4.7
- Topological polar surface area
- 85.2 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 5
- Rotatable bonds
- 5
- Heavy atoms
- 31
- Formal charge
- 0
- Complexity
- 580
Physicochemical properties
- Boiling point
- 690.6 · 690.6±65.0 °C(Predicted)
- Density
- 1.31 · 1.31±0.1 g/cm3(Predicted)
- pka
- 4.16 · 4.16±0.10(Predicted)
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
Agents that antagonize ANGIOTENSIN RECEPTORS. Many drugs in this class specifically target the ANGIOTENSIN TYPE 1 RECEPTOR.
Applications
DescriptionL 158809 is an angiotensin II type 1 receptor antagonist.
UsesL-158809 is an angiotensin type 1 (AT1) receptor antagonist that prevents or ameliorates fractionated whole-brain irradiation-induced cognitive impairment. L-158809 is promising for research of brain tumor[1].
Related reactions
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Compound notes
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