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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 18321Generated: October 31, 2026

2-(Trichloromethyl)oxirane

TRICHLOROPROPANEOXIDE · Trichloroepoxypropane · TRICHLOROPROPYLENEOXIDE · (trichloromethyl)oxirane · Oxirane, 2-(trichloromethyl)- · 3,3,3-TRICHLOROPROPYLENEOXIDE · 1,1,1-TRICHLORO-2,3-EPOXYPROPANE · 1,2-EPOXY-3,3,3-TRICHLOROPROPANE

https://huagongshe.com/en/chemical/18321

2-(Trichloromethyl)oxirane molecular structure

Identifiers & Physical Properties

CAS No.3083-23-6
Molecular formulaC3H3Cl3O
Average molar mass161.41 g/mol
Monoisotopic mass159.924948 g/mol
SMILESClC(Cl)(Cl)C1CO1
InChIKeyVFEXYZINKMLLAK-UHFFFAOYSA-N
PubChem CID18321
EC No.221-384-8
DTXSIDDTXSID3025251

Chemical & Physical Properties

XLogP1.8
Topological polar surface area12.5
Hydrogen bond donors0
Hydrogen bond acceptors1
Rotatable bonds0
Heavy atoms7
Formal charge0
Complexity76
Density1.495 at 68 °F (NTP, 1992) - Denser than waterwill sink1.4950
Solubilityless than 0.1 mg/mL at 65.3 °F (NTP, 1992)
Flash point152 °F (NTP, 1992)
Boiling point300 °F at 764 mmHg (NTP, 1992)226.05°C (rough estimate)
Vapor pressure11.6 mmHg at 77 °F28.5 mmHg at 108 °F65.5 mmHg at 149 °F (NTP, 1992)11.6 [mmHg]
Physical Description1,2-epoxy-3,3,3-trichloropropane is a clear colorless liquid. (NTP, 1992)Clear colorless liquid[CAMEO]
Kovats Retention Index885
Refractive index1.4737 (estimate)
StabilityStable. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference3083-23-6
FDA UNIIIQ92Z3552X
EPA Substance Registry System1,1,1-Trichloro-2,3-epoxypropane (3083-23-6)
GHS pictogramGHS08,GHS07,GHS02
Signal wordWarning
GHS hazard statementsH332-H302-H319-H351-H373-H312-H335-H315-H226
GHS precautionary statementsP264-P270-P301+P312-P330-P501-P201-P202-P281-P308+P313-P405-P501-P261-P271-P304+P340-P312-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P-P280-P302+P352-P312-P322-P363-P501-P260-P314-P501
Toxicitymmo-sat 740 mg/plate APSXAS 17,189,80

Safety & Regulations

GHS classificationWarningH226 (100%): Flammable liquid and vapor [Warning Flammable liquids]H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposureRespiratory tract irritation]H351 (100%): Suspected of causing cancer [Warning Carcinogenicity]H373 (100%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P317, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Fire hazardsThis chemical is combustible. (NTP, 1992)
Health hazardsACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits toxic fumes. (NTP, 1992)
Hazards summaryIntraperitoneal LD50 (rat) = 142 mg/kg[RTECS] Enhances the tumor initiating ability of some carcinogens[ChemIDplus] Highly flammable and polymerizable[CAMEO] See Epibromohydrin and Epichlorohydrin.
Reactive groupHalogenated Organic CompoundsEpoxidesPolymerizable Compounds
Reactivity AlertsPolymerizable
Reactivity ProfileEpoxides are highly reactive. They polymerize in the presence of catalysts or when heated. These polymerization reactions can be violent. Compounds in this group react with acids, bases, and oxidizing and reducing agents. They react, possibly violently with water in the presence of acid and other catalysts.

Applications & Uses

Uses

Trichloropropene Oxide is an epoxide hydratase inhibitor and possess potential carcinogenic properties.

Uses

Trichloropropene Oxide is a epoxide hydratase inhibitor and possess potential carcinogenic properties.

General Description

Clear colorless liquid.

Air and Water ReactionsInsoluble in water.
Hazard Classes and CategoriesFlam. Liq. 3 (100%)Acute Tox. 4 (100%)Skin Irrit. 2 (100%)Eye Irrit. 2 (100%)STOT SE 3 (100%)Carc. 2 (100%)STOT RE 2 (100%)
Fire fightingFires involving this compound should be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
First aidEYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.INHALATION: IMMEDIATELY leave the contaminated areatake deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be usedif not available, use a level of protection greater than or equal to that advised under Protective Clothing.INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)
Nonfire spill responseSMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.STORAGE PRECAUTIONS: You should store this material in a refrigerator. STORE AWAY FROM SOURCES OF IGNITION. (NTP, 1992)
Personal Protective Equipment (PPE)RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)
Toxicitymmo-sat 740 mg/plate APSXAS 17,189,80
Signal wordWarning
GHS pictogramGHS08,GHS07,GHS02
GHS hazard statementsH332-H302-H319-H351-H373-H312-H335-H315-H226
GHS precautionary statementsP264-P270-P301+P312-P330-P501-P201-P202-P281-P308+P313-P405-P501-P261-P271-P304+P340-P312-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P-P280-P302+P352-P312-P322-P363-P501-P260-P314-P501