1,2-Epoxytetradecane

HCID 18604CAS 3234-28-4

Basic information

Standard SMILES
CCCCCCCCCCCCC1CO1
InChIKey
IOHJQSFEAYDZGF-UHFFFAOYSA-N
Molecular formula
C14H28O
Average molar mass
212.37 g/mol
Monoisotopic mass
212.21401551

Names & identifiers

Preferred name
1,2-Epoxytetradecane
IUPAC
2-dodecyloxirane
English name
1,2-Epoxytetradecane
Molecular formula
C14H28O
Molecular weight
212.37

Names & synonyms

1,2-EPOXYTETRADECANE3234-28-41,2-Tetradecylene OxideOxirane, 2-dodecyl-DTXSID90252491-tetradecene oxideCCRIS 2617EINECS 221-781-6AI3-14200DTXCID705249EC 221-781-6dodecylene oxide
Show more names
2-Dodecyloxiranedodecyl-oxirandodecyl-Oxirane2-lauryloxiranen-dodecyloxiraneEPOXY TETRADECANEOxirane, dodecyl-
TETRADECENEEPOXIDERefChem:72062TETRADECENE EPOXIDE(+-)-DODECYLOXIRANE1,2-TETRADECENE OXIDETETRADECANE,1,2-EPOXY-(.+-.)-DODECYLOXIRANETETRADECANE, 1,2-EPOXY-

Database identifiers

CAS
3234-28-4
PubChem CID
18604
DTXSID
DTXSID9025249
ChEMBL
CHEMBL1598368
EC Number
221-781-6
Nikkaji
J91.339A

Properties

Computed structural properties

XLogP
6.3
Topological polar surface area
12.5 Ų
Hydrogen bond donors
0
Hydrogen bond acceptors
1
Rotatable bonds
11
Heavy atoms
15

Experimental & physicochemical properties

Density0.847 (NTP, 1992) - Less dense than water; will float
Solubilityless than 1 mg/mL at 68 °F (NTP, 1992)
Flash Pointgreater than 235 °F (NTP, 1992)
Boiling Point203 to 205 °F at 0.4 mmHg (NTP, 1992)
Melting Pointless than 68 °F (NTP, 1992)
Physical Description · 2 items

1,2-epoxytetradecane is a clear colorless mobile liquid with an ether-like odor. (NTP, 1992)

Liquid

Physicochemical properties

Melting point
185 · 185-186 °C (decomp)
Boiling point
95 · 95-96 °C/0.4 mmHg (lit.)
Density
0.845 g/mL · 0.845 g/mL at 25 °C (lit.)
vapor pressure
0.176 Pa · 0.176Pa at 25℃
refractive index
1.4408 · 1.4408
Flash point
110 °C · >110°C

Safety & regulation

GHS classification

GHS Classification · 6 items

This chemical does not meet GHS hazard criteria for 2.9% (5 of 175) of reports.

Warning

H315 (97.1%): Causes skin irritation [Warning Skin corrosion/irritation];H319 (26.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation];H335 (24%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation];H400 (70.3%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard];H410 (70.3%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P261, P264, P264+P265, P271, P273, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 175 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.;Reported as not meeting GHS hazard criteria per 5 of 175 reports by companies.;There are 9 notifications provided by 170 of 175 reports by companies with hazard statement code(s).;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Hazard information

Regulatory Information · 4 items

Chemical: Oxirane, dodecyl-

Oxirane, 2-dodecyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Oxirane, 2-dodecyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 15-05-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/11734

Oxirane, dodecyl-: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - Long-chain alkyl oxiranes: Human health tier II assessment
Fire HazardsThis chemical is probably combustible. (NTP, 1992)
Health HazardsACUTE/CHRONIC HAZARDS: This compound is a local irritant. (NTP, 1992)
Reactive GroupEpoxides;Polymerizable Compounds
Reactivity AlertsPolymerizable

Safety & protection

Fire FightingFires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
First Aid · 1 item

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.;SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.;INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.;INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

Nonfire Spill Response · 1 item

SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.;STORAGE PRECAUTIONS: You should store this material under freezer conditions. (NTP, 1992)

Personal Protective Equipment (PPE) · 1 item

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Regulatory information

Regulatory Information · 4 items

Chemical: Oxirane, dodecyl-

Oxirane, 2-dodecyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Oxirane, 2-dodecyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 15-05-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/11734

Oxirane, dodecyl-: Does not have an individual approval but may be used under an appropriate group standard

Safety data

PPE
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
wgk
1
tsca
TSCA listed
hs_code
2910.90.9100
risk_code
36/38-36/37/38
Signal word
Warning

Chemistry & industry

Uses & manufacturing

U.S. Production2023: 34,313 lb;2022: 35,775 lb;2021: 45,823 lb;2020: 28,109 lb
Consumer UsesHeat transferring agent
Industry UsesHeat transferring agent
General Manufacturing Information · 2 items

Transportation Equipment Manufacturing

Oxirane, 2-dodecyl-: ACTIVE

Applications

Uses1,2-Epoxytetradecane is used in the preparation of polymeric prodrugs used in treatments of cancer.

General DescriptionClear colorless mobile liquid with an ether-like odor.

Upstream & downstream products

Suppliers50 total

国药集团化学试剂有限公司86-21-63210123 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
苏州道澜生物医药科技有限公司15952404857 · [email protected]
湖北永阔科技有限公司027-59223108 15972152991 · [email protected]
韶远科技(上海)有限公司021-50795510 4000665055 · [email protected]

Related reactions

9 records

Linked notes

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