Aspon

Biological Exposure Indices (BEI) [ACGIH] - Acetylcholinesterase activity in red blood cells = 70% of individual's baseline; Butylcholinesterase activity in serum or plasma = 60% of individual's baseline; Sample at end of shift; [TLVs and BEIs]

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

SYMPTOMATOLOGY: 1. NAUSEA...VOMITING, ABDOMINAL CRAMPS, DIARRHEA, EXCESSIVE SALIVATION... 2. HEADACHE, GIDDINESS, VERTIGO & WEAKNESS. 3. RHINORRHEA & SENSATION OF TIGHTNESS IN CHEST ARE COMMON IN INHALATION EXPOSURE. 4. BLURRING OR DIMNESS OF VISION, MIOSIS... TEARING, CILIARY MUSCLE SPASM, LOSS OF ACCOMMODATION & OCULAR PAIN... MYDRIASIS...SOMETIMES SEEN...PROBABLY DUE TO SYMPATHO-ADRENAL DISCHARGE. 5. LOSS OF MUSCLE COORDINATION, SLURRING OF SPEECH, FASCICULATIONS & TWITCHING OF MUSCLES (PARTICULARLY OF TONGUE & EYELIDS), & GENERALIZED PROFOUND WEAKNESS. 6. MENTAL CONFUSION, DISORIENTATION & DROWSINESS. /PARATHION/

SYMPTOMATOLOGY: 7. DIFFICULTY IN BREATHING, EXCESSIVE SECRETION OF SALIVA & OF RESP TRACT MUCUS, ORONASAL FROTHING, CYANOSIS, PULMONARY RALES & RHONCHI & HYPERTENSION, (PRESUMABLY DUE TO ASPHYXIA). 8. RANDOM JERKY MOVEMENTS, INCONTINENCE, CONVULSIONS, & COMA. 9. DEATH PRIMARILY DUE TO RESP ARREST ARISING FROM FAILURE OF RESP CENTER, PARALYSIS OF RESP MUSCLES, INTENSE BRONCHOCONSTRICTION OR ALL THREE. /PARATHION/

IN 90-DAY FEEDING TRIALS AT SUBLETHAL RATES RATS SHOWED DEPRESSION OF RED BLOOD CELL CHOLINESTERASE.

REPORTED TO BE ANTICHOLINESTERASE OF LOW MAMMALIAN TOXICITY. ...GROWTH OF RATS GIVEN /ORALLY/ 25 MG/KG DAILY IS INHIBITED.

FOURTEEN PESTICIDES INCL ASPON WERE EVALUATED FOR MUTAGENIC POTENTIAL. THE MICROBIAL ASSAY SYSTEMS USED WERE THE HISTIDINE REVERSE MUTATION SYSTEM IN 5 STRAINS OF SALMONELLA TYPHIMURIUM (TA1535, TA1537, TA1538, TA98, & TA100), THE TRYPOTPHAN MUTATION SYSTEM IN ESCHERICHIA COLI WP2, & THE MITOTIC RECOMBINATION ASSAYS IN SACCHAROMYCES CEREVISIAE D3. A MAMMALIAN METABOLIC ACTIVATION SYSTEM USING LIVER OF RATS THAT HAD BEEN TREATED WITH AROCLOR 1254 WAS USED IN ALL ASSAYS. ASPON WAS NONMUTAGENIC. RESULTS OF OTHER CHEMICALS ARE GIVEN.

As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Aspon is found on List A, which contains most food use pesticides and consists of the 194 chemical cases (or 350 individual active ingredients) for which EPA issued registration standards prior to FIFRA, as amended in 1988. Case No: 0019; Pesticide type: Insecticide; Registration Standard Date: 09/01/80; Case Status: No products containing the pesticide are actively registered ... The case /is characterized/ as "cancelled." Under FIFRA, pesticide producers may voluntarily cancel their registered products. EPA also may cancel pesticide registrations if registrants fail to pay required fees or make/meet certain reregistration commitments, or if EPA reaches findings of unreasonable adverse effects.; Active ingredient (AI): Aspon; AI Status: The active ingredient is no longer contained in any registered pesticide products ... "cancelled."