CAS 3288-80-0 Hydrazinium, 1,1,1-trimethyl-, iodide (1:1) (HCID 18683)

Names & identifiers

Preferred name: Hydrazinium, 1,1,1-trimethyl-, iodide (1:1)
IUPAC: amino(trimethyl)azanium iodide
English name: 1,1,1-TRIMETHYLHYDRAZINIUM IODIDE
Molecular formula: C3H11IN2
Molecular weight: 202.04

Names & synonyms

3288-80-0Trimethylhydrazonium iodideHYDRAZINIUM, 1,1,1-TRIMETHYL-, IODIDENSC 33596NSC 123999Hydrazonium, 1,1,1-trimethyl-, iodideHydrazinium, 1,1,1-trimethyl-, iodide (1:1)RefChem:147028628-240-71,1,1-Trimethylhydrazinium iodideMFCD00464984amino(trimethyl)azanium;iodide

Show more names

Mildronate Impurity 1Allopurinol Impurity 13amino(trimethyl)azanium:iodide1,1,1-trimethyl-hydrazoniuiodide1,1,1-trimethyl-hydraziniuiodide1,1,1-TRIMETHYLHYDRAZONIUM IODIDE1,1,1-Trimethyl-1-hydrazinium Iodide1,1,1-TriMethylhydraziniuM iodide 97%

trimethylhydrazinium iodide1,1,1-TRIMETHYLHYDRAZINIUMIODIDE1,1-Trimethylhydrazinium iodide1,1,1-Trimethylhydrazin-1-ium iodideHydrazinium,1,1-trimethyl-, iodideHydrazonium,1,1-trimethyl-, iodideamino(trimethyl)azaniumamino(trimethyl)azanium,iodide

Database identifiers

CAS: 3288-80-0
PubChem CID: 18683
DTXSID: DTXSID00954539
EC Number: 628-240-7

Properties

Computed structural properties

Topological polar surface area: 26 Å²
Hydrogen bond donors: 1
Hydrogen bond acceptors: 2
Rotatable bonds: 0
Heavy atoms: 6
Formal charge: 0
Complexity: 26

Experimental & physicochemical properties

Physical DescriptionWhite powder; [Sigma-Aldrich MSDS]

Physicochemical properties

Melting point: 225 · 225-230 °C (dec.) (lit.)
storage temp.: 2 · 2-8°C, sealed storage, away from moisture and light
Appearance: White to off-white Solid
InChI: 1S/C3H11N2.HI/c1-5(2,3)4;/h4H2,1-3H3;1H/q+1;/p-1
InChIKey: HLNPDVKKRBWQAA-UHFFFAOYSA-M
SMILES: [I-].C[N+](C)(C)N
EPA Substance Registry System: 1 · 1,1,1-trimethylhydrazinium iodide (3288-80-0)
UNSPSC Code: 12352100 · 12352100
NACRES: 22 · NA.22
Symbol(GHS): 7 · GHS07,GHS08
Signal word: Danger
Hazard statements: 315 · H315-H319-H335-H360
Precautionary statements: 201 · P201-P302+P352-P305+P351+P338-P308+P313
target organs: Respiratory system
PPE: 2 · Eyeshields, Gloves, type P2 (EN 143) respirator cartridges
Hazard Codes: T
Risk Statements: 61 · 61-36/37/38
Safety Statements: 53 · 53-36/37/39-45
WGK Germany: 3 · 3
RTECS: 349100 · MW0349100
TSCA: TSCA listed
HS Code: 2928009090 · 2928009090
Storage Class: 6.1 C · 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
Hazard Classifications: 2 Repr · Eye Irrit. 2Repr. 1BSkin Irrit. 2STOT SE 3

Safety & regulation

GHS classification

GHS Classification · 5 items

Danger

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]；H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]；H360 (100%): May damage fertility or the unborn child [Danger Reproductive toxicity]

P203, P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 39 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Hazard information

Hazards Summary · 1 item

Causes convulsions and cardiac changes in intraperitoneal lethal-dose studies of mice; LD50 = 255 mg/kg; [RTECS] A skin and strong eye irritant; Possible reproductive toxicant and teratogen; [Sigma-Aldrich MSDS] See 1,2-Dimethylhydrazine. See Iodine for the TLV of Iodides.

Hazard Classes and CategoriesSkin Irrit. 2 (100%)；Eye Irrit. 2 (100%)；STOT SE 3 (100%)；Repr. 1B (100%)

Toxicology

Adverse EffectsNeurotoxin - Other CNS neurotoxin

Safety data

PPE: Eyeshields, Gloves, type P2 (EN 143) respirator cartridges
wgk: 3
tsca: TSCA listed
rtecs: MW0349100
hs_code: 2928009090
risk_code: 61-36/37/38
Signal word: Danger
Symbol(GHS): GHS07,GHS08
hazard_code: T
safety_code: 53-36/37/39-45
Storage Class: 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
target organs: Respiratory system
Hazard statements: H315-H319-H335-H360
Hazard Classifications: Eye Irrit. 2Repr. 1BSkin Irrit. 2STOT SE 3
Precautionary statements: P201-P302+P352-P305+P351+P338-P308+P313

Chemistry & industry

Uses & manufacturing

General Manufacturing InformationHydrazinium, 1,1,1-trimethyl-, iodide (1:1): ACTIVE

Applications · 2 items

Uses1,1,1-Trimethylhydrazinium iodide (TMHI) may be employed for the amination of 1-X-3,5-dinitrobenzenes.

General Description1,1,1-Trimethylhydrazinium iodide ([(CH3)3N-NH2]I, TMHI) is widely employed as a vicarious nucleophilic substitution (VNS) reagent for various aromatic amination reactions. On reaction with silver salt, it affords the following salts: nitrate (([(CH3)3N-NH2][NO3]), perchlorate ([(CH3)3N-NH2][ClO4]), azide ([(CH3)3N-NH2][N3]), 5-amino-1H-tetrazolate ([(CH3)3N-NH2][H2N-CN4]) and sulfate ([(CH3)3N-NH2]2[SO4].2H2O).