Basic information
- Standard SMILES
CCCCCCCCCCCCCCCCOP(=O)(O)O- InChIKey
ZUVCYFMOHFTGDM-UHFFFAOYSA-N- Molecular formula
- C16H35O4P
- Average molar mass
- 322.42 g/mol
- Monoisotopic mass
- 322.22729623
Overview
The CIR Expert Panel concluded the following 28 alkyl phosphates are safe in the present practices of use and concentration in cosmetics when formulated to be non-irritating...Cetyl Phosphate...
Names & identifiers
- Preferred name
- Hexadecyl phosphate
- IUPAC
- hexadecyl dihydrogen phosphate
- English name
- AMPHISOL A
- Molecular formula
- C16H35O4P
- Molecular weight
- 322.42
Names & synonyms
Hexadecyl dihydrogen phosphate3539-43-3Hexadecyl phosphateCETYL PHOSPHATE1-Hexadecanol, dihydrogen phosphateHostaphat CC 100VT07D6X67OMACKESTER CEPCRODAFOS MCADTXSID1045039RefChem:786052DTXCID9025039
Show more names
Cetyl Phosphate (AMPHISOL A)cetylphosphatehexadecylphosphatecethylphosphoric esterMONO-N-HEXADECYLPHOSPHATEHexadecyldihydrogenphosphatZUVCYFMOHFTGDM-UHFFFAOYSA-NPHOSPHORICMONOHEXADECYL ESTER
222-581-1AMPHISOL Amonocetyl phosphate1-Hexadecanol,1-(dihydrogen phosphate)cetyl dihydrogen phosphateUNII-VT07D6X67OPhosphoric acid monohexadecyl esterEINECS 222-581-1
Database identifiers
- CAS
3539-43-3- PubChem CID
- 19059
- DTXSID
DTXSID1045039- ChEMBL
CHEMBL479322- UNII
- VT07D6X67O
- EC Number
- 222-581-1
- Nikkaji
- J216.184B
Properties
Computed structural properties
- XLogP
- 6.2
- Topological polar surface area
- 66.8 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 16
- Heavy atoms
- 21
- Formal charge
- 0
- Complexity
- 253
Experimental & physicochemical properties
Cosmetics
Cosmetic ingredients (Cetyl Phosphate) -> CIR (Cosmetic Ingredient Review)
Emulsifying
Physical DescriptionDry Powder; Liquid
Physicochemical properties
- Melting point
- 71 °C · 71 °C
- Boiling point
- 439.8 · 439.8±28.0 °C(Predicted)
- Density
- 1.013 · 1.013±0.06 g/cm3(Predicted)
- vapor pressure
- 0.146 Pa · 0.146Pa at 25℃
- pka
- 1.95 · 1.95±0.10(Predicted)
- Odor
- 100 % · at 100.00%. bland
- Water Solubility
- 1 mg/L · 1mg/L at 25℃
- Cosmetics Ingredients Functions
- SURFACTANT - CLEANSINGSURFACTANT - EMULSIFYING
- Cosmetic Ingredient Review (CIR)
- AMPHISOL A (3539-43-3)
- InChI
- InChI=1S/C16H35O4P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20-21(17,18)19/h2-16H2,1H3,(H2,17,18,19)
- InChIKey
- ZUVCYFMOHFTGDM-UHFFFAOYSA-N
- SMILES
- C(OP(O)(O)=O)CCCCCCCCCCCCCCC
- LogP
- 6.65 at · 6.65 at 25℃
- FDA UNII
- 7 D6X67O · VT07D6X67O
- EPA Substance Registry System
- 1 · 1-Hexadecanol, dihydrogen phosphate (3539-43-3)
- Symbol(GHS)
- 5 · GHS05
- Signal word
- Danger
- Hazard statements
- 318 · H318
- Precautionary statements
- 280 · P280-P305+P351+P338-P310
- TSCA
- TSCA listed
- REACH Registrations
- Active
Safety & regulation
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 14.6% (6 of 41) of reports.
Danger
H315 (70.7%): Causes skin irritation [Warning Skin corrosion/irritation]
P264, P264+P265, P280, P302+P352, P305+P354+P338, P317, P321, P332+P317, and P362+P364 (click each P-code to see the statement)
Aggregated GHS information provided per 41 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory Information
Chemical: 1-Hexadecanol, dihydrogen phosphate
1-Hexadecanol, 1-(dihydrogen phosphate) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1-Hexadecanol, 1-(dihydrogen phosphate) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.
Status: Active Update: 29-05-2020 https://echa.europa.eu/registration-dossier/-/registered-dossier/29649
1-Hexadecanol, dihydrogen phosphate: Does not have an individual approval but may be used under an appropriate group standard
Hazard Classes and CategoriesSkin Irrit. 2 (70.7%)
Toxicology
Toxicity Summary
The CIR Expert Panel concluded the following 28 alkyl phosphates are safe in the present practices of use and concentration in cosmetics when formulated to be non-irritating...Cetyl Phosphate...
Safe for use in cosmetics, with qualifications
Safety data
- tsca
- TSCA listed
- Signal word
- Danger
- Symbol(GHS)
- GHS05
- Hazard statements
- H318
- REACH Registrations
- Active
- Precautionary statements
- P280-P305+P351+P338-P310
Chemistry & industry
Uses & manufacturing
UsesCIR ingredient: Cetyl Phosphate
U.S. Production2023: 100,000 - <250,000 lb
Consumer UsesEmulsifier
Industry UsesLubricating agent
Household ProductsInformation on 3 consumer products that contain Cetyl phosphate in the following categories is provided:
Use ClassificationCosmetics -> Emulsifying
General Manufacturing Information
Fabricated Metal Product Manufacturing
1-Hexadecanol, 1-(dihydrogen phosphate): ACTIVE
Applications
UsesAMPHISOL A is used as o/W type mild anionic emulsifier/stabilizer, easy to handle and mold.
Suppliers50 total
北京华美互利生物化工010-56205725 · [email protected]
郑州阿尔法化工有限公司+86-18530059196 · [email protected]
陕西缔都新材料有限公司81124267 17392282731 · [email protected]
Hebei Chuanghai Biotechnology Co., Ltd+86-17732866630 · [email protected]
Hebei Zhuanglai Chemical Trading Co Ltd+86-16264648883 · [email protected]
南通鲁尔化工有限公司18012215199 · [email protected]
郑州汇聚化工有限公司0371-53399770 18037166334 · [email protected]
湖北盛明安化工有限公司13928406992 · [email protected]
武汉欣扬瑞和化学科技有限公司153-07155313 15307155313 · [email protected]
武汉绿景丰华生物科技有限公司19972070065 · [email protected]
武汉市聚舜化工有限公司027-02783261126 18971318572 · [email protected]
梯希爱（上海）化工贸易有限公司021-61109150 · [email protected]
广东云星生物技术有限公司0751-18902340975/189023400307 18902340307 · [email protected]
江苏艾康生物医药研发有限公司025-5885952 15955137747 · [email protected]
武汉丰泰威远科技有限公司+86-27-8746-5837 +86-18627785180 · [email protected]
武汉丰泰威远科技有限公司027-87465837 19945049750 · [email protected]
武汉贝乐叶生物医药科技有限公司15871353653 18086118076 · [email protected]
Hebei Zhuanglai Chemical Trading Co.,Ltd13343047651 · [email protected]
武汉欣扬瑞和化学科技有限公司027-83855316 18171155316
康迪斯化工（湖北）有限公司13125172151 · [email protected]
康迪斯化工(湖北)有限公司13343438265 · [email protected]
海南瀚海致远生物科技有限公司18171012772 · [email protected]
广东翁江化学试剂有限公司0751-2815987 13927875076 · [email protected]
厦门志信化学有限公司+86-5922680277 +86-13806087780 · [email protected]
广东翁江化学试剂有限公司0751-2886766 13927870850 · [email protected]
荆州市尹杰化工有限公司18008658728 · [email protected]
启源（广东）医药化工有限公司18026564465 · [email protected]
湖北阡陌生物科技有限公司0711-3812399 18062309155 · [email protected]
湖北鑫杰成化工科技有限公司18008658050 18008658050 · [email protected]
佛山晟熠生物科技有限公司18064670521 · [email protected]
湖北中隆康盛精细化工有限公司027-83850381 18171045381
武汉柔博医药化工有限公司027-027-87827088 18986164924 · [email protected]
上海易恩化学技术有限公司400-400-1332688 18019345275 · [email protected]
杭州凡达化工有限公司008657128800458 · [email protected]
上海帅燊实业有限公司021-37590756 57450129
成都圣美凯生物科技有限公司028-85157043 15882256948 · [email protected]
上海问彩新材料科技有限公司15721586846 · [email protected]
武汉欣扬瑞和化学科技有限公司15926260361 · [email protected]
上海鼎芬化学科技有限公司021-37590756 · [email protected]
湖北达豪化工有限公司027-027-59106191 13986034860 · [email protected]
湖北中隆康盛精细化工有限公司027-027-82752821 18186694582 · [email protected]
XIAMEN AMITY INDUSTRY AND TRADE CO., LTD.+8618950047208 · [email protected]
山东穗华生物科技有限公司15169101773 15169101773
湖北臻博化工有限公司18040568358 18086513998
湖北拓邦化工有限公司027-59106185 13986192185 · [email protected]
湖北中隆康盛精细化工有限公司027-027-83850178 18162590268 · [email protected]
SHANGHAI KEAN TECHNOLOGY CO., LTD.+8613817748580 · [email protected]
SUZHOU SENFEIDA CHEMICAL CO.,LTD+86-0512-83500002 +86-15195660023 · [email protected]
BOC Sciences+1-631-485-4226 · [email protected]
武汉欣扬瑞和化学科技有限公司027-18120580375 18120580375 · [email protected]
Related reactions
11 records
Linked notes
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