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Basic information
- CAS
151928-32-4- Standard SMILES
CC(C)=CCc1cc([C@@H](O)[C@@H](C=O)NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H]2CC=CN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)CN)C(C)C)ccc1O- InChIKey
MZGWPVIVGCXMPX-QFXPHGGCSA-N- Molecular formula
- C41H52N8O9
- Average molar mass
- 800.8998 g/mol
Names & identifiers
- Preferred name
- WIN 66306
- English name
- WIN 66306
- Molecular formula
- C41H52N8O9
- Molecular weight
- 800.89978
Names & synonyms
WIN 66306cyclo[glycyl-L-tryptophyl-L-prolylglycyl-L-valylglycyl-(βR)-β-hydroxy-3-(3-methyl-2-butenyl)-L-tyrosyl
Database identifiers
- CAS
151928-32-4- PubChem CID
- 192562
Properties
Physicochemical properties
- Sequence
- -3 · Cyclo(Gly-Trp-Pro-Gly-Val-Gly-{(βR)-β-OH-3-(3-Me-2-Butenyl)-Tyr})
Chemistry & industry
Applications
DescriptionWIN 66306 is a cyclic heptapeptide antagonist of neurokinin-1 (NK1) and NK2 receptors originally isolated from A. flavipes. It binds to NK1 and NK2 receptors and inhibits contractions induced by substance P in isolated guinea pig ileum in a concentration-dependent manner.
UsesWIN 66306 is a cyclic heptapeptide that can be isolated from an Aspergillus species. WIN 66306 is a neurokinin antagonist with antagonistic effects on both NK1 and NK2 receptors[1][2].
Suppliers7 total
上海赛可锐生物科技有限公司021-58000709 13120558703 · [email protected]
上海维亦特生物科技有限公司15317051735 · [email protected]
ChemeGen 中国18818260767 · [email protected]
北京百奥创新科技有限公司15522676233 · [email protected]
TargetMol中国（陶术生物）4008200310 15002144251 · [email protected]
上海一飞生物科技有限公司021-65675885 18964387627 · [email protected]
南京世洲生物科技有限公司025-85560043 15850508050 · [email protected]
Related reactions
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Compound notes
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