Sulfotep

(Non-Specific -- Organophosphorus Pesticide, n.o.s.) Wear positive pressure breathing apparatus and special protective clothing.；(Non-Specific -- Organophosphorus Pesticide, n.o.s.) For small fires, use dry chemical, carbon dioxide, water spray, or foam. For large fires, use water spray, fog, or foam. Fight fire from maximum distance. (EPA, 1998)

Use water spray, foam, powder, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

Rinse and then wash skin with water and soap. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention .

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.；· Keep unauthorized personnel away.；· Stay upwind, uphill and/or upstream.；· Ventilate closed spaces before entering, but only if properly trained and equipped.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.；· Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.；· Stop leak if you can do it without risk.；· Prevent entry into waterways, sewers, basements or confined areas.；· Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.；· DO NOT GET WATER INSIDE CONTAINERS.

Warning: Effects may be delayed up to 12 hours. Caution is advised.；Note: Sulfotep is a cholinesterase inhibitor.；Signs and Symptoms of Sulfotep Exposure: Acute exposure to sulfotep may produce the following signs and symptoms: sweating, pinpoint pupils, blurred vision, headache, dizziness, profound weakness, muscle spasms, seizures, and coma. Mental confusion and psychosis may occur. Excessive salivation, nausea, vomiting, anorexia, diarrhea, and abdominal pain may also occur. The heart rate may decrease following oral exposure or increase following dermal exposure. Chest pain may be noted. Hypotension (low blood pressure) may be observed, although hypertension (high blood pressure) is not uncommon. Respiratory signs include dyspnea (shortness of breath), pulmonary edema, respiratory depression, and respiratory paralysis.；Emergency Life-Support Procedures: Acute exposure to sulfotep may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.；Inhalation Exposure:；1. Move victims to fresh air. Emergency personnel should avoid self-exposure to sulfotep.；2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.；3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.；4. RUSH to a health care facility!；Dermal/Eye Exposure:；1. Remove victims from exposure. Emergency personnel should avoid self-exposure to sulfotep.；2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.；3. Remove and isolate contaminated clothing as soon as possible.；4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.；5. Wash exposed skin areas thoroughly with water.；6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.；7. RUSH to a health care facility!；Ingestion Exposure:；1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.；2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.

General First Aid:；· Call 911 or emergency medical service.；· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.；· Move victim to fresh air if it can be done safely.；· Administer oxygen if breathing is difficult.；· If victim is not breathing:；-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.；-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).；-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.；· Remove and isolate contaminated clothing and shoes.；· For minor skin contact, avoid spreading material on unaffected skin.；· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.；· For severe burns, immediate medical attention is required.；· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.；· Keep victim calm and warm.；· Keep victim under observation.；· For further assistance, contact your local Poison Control Center.；· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.；Specific First Aid:；· For corrosives, in case of contact, immediately flush skin or eyes with running water for at least 30 minutes. Additional flushing may be required.

(General first aid procedures)；Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.；Skin: Soap wash immediately - If this chemical contacts the skin, immediately wash the contaminated skin with soap and water. If this chemical penetrates the clothing, immediately remove the clothing, wash the skin with soap and water, and get medical attention promptly.；Breathing: Respiratory support；Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately.

Dry. Well closed. Separated from strong oxidants and food and feedstuffs. Keep in a well-ventilated room. Do NOT store or transport in containers made from metal. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing.

· Wear positive pressure self-contained breathing apparatus (SCBA).；· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.；· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

Biological Exposure Indices (BEI) [ACGIH] - Acetylcholinesterase activity in red blood cells = 70% of individual's baseline; Butylcholinesterase activity in serum or plasma = 60% of individual's baseline; Sample at end of shift; [TLVs and BEIs]

0.13 [mg/m3], inhalable fraction[German Research Foundation (DFG)]

Extinguish fire using agent suitable for type of surrouding fire (material itself does not burn or burns with difficulty). Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. /Tetraethyl dithiopyrophosphate mixture, dry/

If material is involved in fire: Extinguish fire using agent suitable for type of surrounding fire (material itself does not burn or burns with difficulty). Use water in flooding quantities as fog. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use alcohol foam, dry chemical, or carbon dioxide. /Tetraethyl dithiopyrophosphate and compressed gas mixture or liquid/

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use foam, dry chemical, or carbon dioxide. Use water spray to knock down vapors. /Tetraethyl dithiopyrophosphate mixture, liquid/

(Non-Specific -- Organophosphate Pesticide) Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Remove and isolate contaminated clothing at the site. Do not touch spilled material; stop leak if you can do it without risk. Use water spray to reduce vapors.；Small spills: take up with sand or other noncombustible absorbent material and place into containers for later disposal.；Large spills: dike far ahead of spill for later disposal. (EPA, 1998)

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number P109, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

Potential candidate for rotary kiln incineration with a temperature range of 820 to 1600 °C with residence times for liquids and gases: seconds; solids, hours. Also, a potential candidate for liquid injection incineration with a temperature range of 650 to 1600 °C with residence times of 0.1 to 2 seconds. Also, a potential candidate for fluidized bed incineration with a temperature range of 450 to 980 °C with residence times for liquids and gases, seconds; solids, longer.

This compound should be susceptible to removal from wastewater by air stripping.

Incinerate with added flammable solvent in furnace equipped with afterburner and alkaline scrubber. Recommendable method: Incineration.

Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in dry sand or inert absorbent. Then store and dispose of according to local regulations.

Employees should wash immediately when skin is wet or contaminated. Remove non-impervious clothing immediately if wet or contaminated.

Evacuation: If material is leaking (not on fire), consider evacuation from from downwind area based on amount of material spilled, location, and weather conditions. /Tetraethyl dithiopyrophosphate, mixture, liquid or tetraethyl dithiopyrophosphate, liquid/

Evacuation: If material leaking (not on fire) consider evacuation from downwind area based on amount of material spilled, location, and weather conditions. /Tetraethyl dithiopyphosphate and compressed gas mixture/

Avoid breathing vapors. Keep upwind. ... Avoid bodily contact with the material. ... Do not handle broken packages without protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water. /Tetraethyl dithiopyrophosphate and compressed gas mixture or tetraethyl dithiopyrophosphate mixture, dry or tetraethyl dithiopyrophosphate mixture, liquid or tetraethyl dithiopyrophosphate, liquid/

For more Preventive Measures (Complete) data for SULFOTEP (13 total), please visit the HSDB record page.

Nervous

Eyes, skin, respiratory system, central nervous system, cardiovascular system, blood cholinesterase

LC50 Pimephales promelas (fathead minnow) 0.178 mg/l/96 hr /Conditions of bioassay not specified/

LC50 Lepomis macrochirus (bluegill sunfish) 0.0016 mg/l/96 hr /Conditions of bioassay not specified/

LC50 Rainbow trout 0.018 mg/l/96 hr /Conditions of bioassay not specified/

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 3,500(SRC), determined from a log Kow of 3.99(2) and a regression-derived equation(4), indicates that sulfotep is expected to have slight mobility in soil(SRC). Volatilization of sulfotep from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 4.4X10-6 atm-cu m/mole(SRC) derived from its vapor pressure, 1.05X10-4 mm Hg(2), and water solubility, 30 mg/l(3). However, adsorption to soil is expected to attenuate volatilization(SRC). Sulfotep is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(2). No soil biodegradation data were located(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 3,500(SRC), determined from a log Kow of 3.99(2) and a regression-derived equation(4), indicates that sulfotep is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(4) based upon an estimated Henry's Law constant of 4.4X10-6 atm-cu m/mole(SRC), derived from its vapor pressure, 1.05X10-4 mm Hg(2), and water solubility, 30 mg/l(3). Using this Henry's Law constant and an estimation method(4), volatilization half-lives for a model river and model lake are 28 and 206 days, respectively(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The estimated volatilization half-life from a model pond is 68 months if adsorption is considered(5). Sulfotep underwent no observable photolysis upon laboratory irradiation in pure water(6). According to a classification scheme(7), an estimated BCF of 240(SRC), from its log Kow(2) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms high(SRC). No aquatic biodegradation data were located(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), sulfotep, which has a vapor pressure of 1.05X10-4 mm Hg at 20 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase sulfotep is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 2 hrs(SRC), calculated from its rate constant of 1.8X10-10 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Sulfotep underwent no observable photolysis upon laboratory irradiation in pure water(4).

Sulfotep was listed as a pesticide found infrequently in leaf and stem vegetables, 1970-1976(1). The compound was not detected during 1994 regulatory monitoring of 329 pesticides conducted in the US(2). Sulfotep was detected in 1 of 31 Danish pepper samples collected in 1996 for the Danish National Pesticide Monitoring Program(3).

The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

inhalation, skin absorption, ingestion, skin and/or eye contact

Blue lips, fingernails and skin. Dizziness. Drowsiness. Headache. Pupillary constriction, muscle cramp, excessive salivation. Sweating. Laboured breathing. Nausea. Convulsions. Unconsciousness. Weakness. See Ingestion.

MAY BE ABSORBED! Redness. Further see Inhalation.

Redness. Pain. Pupillary constriction.

Abdominal cramps. Confusion. Diarrhoea. Vomiting. Further see Inhalation.

irritation eyes, skin; eye pain, blurred vision, lacrimation (discharge of tears); rhinorrhea (discharge of thin nasal mucus); headache; cyanosis; anorexia, nausea, vomiting, diarrhea; localized sweating, lassitude (weakness, exhaustion), twitching, paralysis, Cheyne-Stokes respiration, convulsions, low blood pressure, cardiac irreg

Tetraethyldithiopyrophosphate

Nervous

5 x 10 ^-4 mg/kg-day

Consider the points of attack /central nervous system, respiratory system, cardiovascular system/ in preplacement and periodic physical examinations.

/Protect/ from exposure when cholinesterase in red blood cell or plasma falls to 50% of normal. May return to work when cholinesterase is again above 75% of normal.

Hazard Traits - Developmental Toxicity; Environmental tox; Neurotoxicity；Authoritative List - CECBP - Priority Chemicals; CWA 303(d)；Report - if used as a fragrance or flavor ingredient

2002/2076

Sulfotep: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

P109; As stipulated in 40 CFR 261.33, when tetraethyldithiopyrophosphate, as a commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate, becomes a waste, it must be managed according to federal and/or state hazardous waste regulations. Also defined as a hazardous waste is any container or inner liner used to hold this waste or any residue, contaminated soil, water, or other debris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of this waste may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5(e)).

The registrants have been unable to support the data requirements for reregistration and have signed an agreement for voluntary cancellation. The cancellation will take effect September 30, 2002, with an existing stocks provision in effect until September 30, 2004. The registrants have agreed to request interim label amendments to address risks of concern posed by the use of sulfotepp.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 100 lb or 45.4 kg. The toll free number of the NRC is (800) 424-8802; In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

Releases of CERCLA hazardous substances are subject to the release reporting requirement of CERCLA section 103, codified at 40 CFR part 302, in addition to the requirements of 40 CFR part 355. Sulfotep is an extremely hazardous substance (EHS) subject to reporting requirements when stored in amounts in excess of its threshold planning quantity (TPQ) of 500 lbs.