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Lidocaine mixture with tribenoside

HCID 196121
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Basic information

CAS
78940-02-0
Standard SMILES
CCN(CC)CC(=O)Nc1c(C)cccc1C.CCOC1O[C@H]([C@@H](COCc2ccccc2)OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1O
InChIKey
SYDMLWPJVQFLPW-UKSDMRDESA-N
Molecular formula
C43H56N2O7
Average molar mass
712.9 g/mol
Monoisotopic mass
712.40875213

Overview

Lidocaine Mixture with Tribenoside is a formulation composed of the local anesthetic lidocaine and the vasoprotective agent tribenoside that can be used for the treatment of hemorrhoids. Upon rectal administration of the lidocaine mixture with tribenoside, lidocaine stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thereby inhibiting the ionic fluxes required for the initiation and conduction of impulses. This causes local anesthesia and relieves pain. Tribenoside may exert anti-inflammatory, mild analgesic, wound-healing, fibrinolysis-promoting, membrane-stabilizing and venotropic properties. This may relieve pain, halt inflammation, protect blood vessels, and may help repair and heal wounds.

Names & identifiers

Preferred name
Lidocaine mixture with tribenoside
IUPAC
(3R,4R,5R)-5-[(1R)-1,2-bis(phenylmethoxy)ethyl]-2-ethoxy-4-phenylmethoxyoxolan-3-ol;2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide
English name
tribenoside (combination)
Molecular formula
C43H56N2O7
Molecular weight
712.91394

Names & synonyms

Procto-glyvenol78940-02-0D-Glucofuranoside, ethyl 3,5,6-tris-O-(phenylmethyl)-, mixt. with 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamideRefChem:924742Tribenoside (combination)SCHEMBL29539406DTXSID601000148(3R,4R,5R)-5-[(1R)-1,2-bis(phenylmethoxy)ethyl]-2-ethoxy-4-phenylmethoxyoxolan-3-ol;2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide(Diethylamino)-N-(2,6-dimethylphenyl)ethanimidic acid--ethyl 3,5,6-tri-O-benzyl-D-glucofuranoside (1/1)2-(Diethylamino)-N-(2,6-dimethylphenyl)ethanimidic acid--ethyl 3,5,6-tri-O-benzylhexofuranoside (1/1)

Database identifiers

CAS
78940-02-0
PubChem CID
196121
DTXSID
DTXSID601000148

Properties

Computed structural properties

Topological polar surface area
98.7 Ų
Hydrogen bond donors
2
Hydrogen bond acceptors
8
Rotatable bonds
18
Heavy atoms
52
Formal charge
0
Complexity
784

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