Streptomycin Sulfate
Basic information
- CAS
3810-74-0- Standard SMILES
CN[C@@H]1[C@H](O[C@H]2[C@H](O[C@H]3[C@H](O)[C@@H](O)[C@H](N=C(N)N)[C@@H](O)[C@@H]3N=C(N)N)O[C@@H](C)[C@]2(O)C=O)O[C@@H](CO)[C@H](O)[C@H]1O.CN[C@@H]1[C@H](O[C@H]2[C@H](O[C@H]3[C@H](O)[C@@H](O)[C@H](N=C(N)N)[C@@H](O)[C@@H]3N=C(N)N)O[C@@H](C)[C@]2(O)C=O)O[C@@H](CO)[C@H](O)[C@H]1O.O=S(=O)(O)O.O=S(=O)(O)O.O=S(=O)(O)O- InChIKey
QTENRWWVYAAPBI-YCRXJPFRSA-N- Molecular formula
- C42H84N14O36S3
- Average molar mass
- 1,457.4 g/mol
- Monoisotopic mass
- 1,456.4334786
Overview
Streptomycin Sulfate can cause developmental toxicity according to state or federal government labeling requirements.
Names & identifiers
- Preferred name
- Streptomycin Sulfate
- IUPAC
- bis(2-[(1R,2R,3S,4R,5R,6S)-3-(diaminomethylideneamino)-4-[(2R,3R,4R,5S)-3-[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy-4-formyl-4-hydroxy-5-methyloxolan-2-yl]oxy-2,5,6-trihydroxycyclohexyl]guanidine);sulfuric acid
- English name
- Streptomycin sulfate
- Molecular formula
- C21H41N7O16S
- Molecular weight
- 679.65
Names & synonyms
Streptomycin sulfateStreptomycin sulphate3810-74-0StrepcinStrycinVetstrepAmbistryn SAgri-StrepAgrimycin sulfateAgrimycin 17Streptomycin A sulfateStreptorex
Show more names
Streptomycin Sulphate SterileStreptoStreptoMycin sulfatStreptomycine sulphateplantomycinEstreptomicinaSTREPTOMYCIN SULFATE SALTSTREPTOMYCIN SESQUISULFATE
AgristrepStrep-granStreptomycin (as sulfate)CW25IKJ202Streptomycin sulfate (2:3) (salt)CHEBI:32158AS-15Streptomycini sulfas
Database identifiers
- CAS
3810-74-0- PubChem CID
- 19648
- ChEMBL
CHEMBL3184791
Properties
Computed structural properties
- Topological polar surface area
- 922 Ų
- Hydrogen bond donors
- 30
- Hydrogen bond acceptors
- 42
- Rotatable bonds
- 18
- Heavy atoms
- 95
- Formal charge
- 0
- Complexity
- 1,020
Experimental & physicochemical properties
Solubilitygreater than or equal to 0.1 mg/mL at 64 °F (NTP, 1992)
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Animal DrugsFDA approved animal drugs -> Active ingredient
Physical DescriptionStreptomycin sulfate (2:3) (salt) appears as an antibacterial. White to light gray or pale buff powder with faint amine-like odor.
Physicochemical properties
- Melting point
- 185 °C · >185°C (dec.)
- alpha
- -79 · -79~-88°(20℃/D)(c=1,H2O)(calculated on the dried basis)
- Density
- 1.2302 · 1.2302 (rough estimate)
- refractive index
- -85 ° · -85 ° (C=1, H2O)
- storage temp.
- 2 · 2-8°C
- solubility
- 2 O: · H2O: 0.1 g/mL, clear
- form
- powder
- color
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 0.3% (1 of 303) of reports.
Danger
H302 (43.9%): Harmful if swallowed [Warning Acute toxicity, oral]
P203, P260, P261, P264, P264+P265, P270, P271, P272, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P330, P333+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 303 reports by companies from 22 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory Information
Chemical: D-Streptamine, O-2-deoxy-2-(methylamino)-.alpha.-L-glucopyranosyl-(1.fwdarw.2)-O-5-deoxy-3-C-formyl-.alpha.-L-lyxofuranosyl-(1.fwdarw.4)-N,N'-bis(aminoiminomethyl)-, sulfate (2:3)(salt)
Hazard Traits - Developmental Toxicity
Streptomycin Sesquisulfate is listed in the dataset of EPA Human Health Benchmarks for Pesticides under the Safe Drinking Water Act (40 eCFR 141)
Streptomycin sesquisulphate: Does not have an individual approval but may be used under an appropriate group standard
Fire HazardsFlash point data for this chemical are not available, however it is probably combustible. (NTP, 1992)
Health HazardsSYMPTOMS: Symptoms of exposure to this compound include skin rashes, eosinophilia, blood dyscrasias, stomatitis, anaphylactic shock, pruritus, scaling, and fever. (NTP, 1992)
Reactive GroupAlcohols and Polyols
Reactivity ProfileSTREPTOMYCIN SULFATE (2:3) (SALT) is a medicinal amino saccharide.
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins.
Substances that inhibit the growth or reproduction of BACTERIA.
Uses & manufacturing
Household ProductsInformation on 1 consumer products that contain Streptomycin sulfate in the following categories is provided:
General Manufacturing InformationD-Streptamine, O-2-deoxy-2-(methylamino)-.alpha.-L-glucopyranosyl-(1.fwdarw.2)-O-5-deoxy-3-C-formyl-.alpha.-L-lyxofuranosyl-(1.fwdarw.4)-N1,N3-bis(aminoiminomethyl)-, sulfate (2:3): ACTIVE
Applications
UsesIt is used for treating tuberculosis, Brinell and non-hemolytic hammer bacillus caused infectious endocarditis, plague and tularemia, Haemophilus influenzae and gram-negative bacilli caused infections.
DescriptionStreptomycin was found in the culture broth of Streptomyces griseus by S. A. Waksman of Rutgers University in 1944; it was the second antibiotic introduced clinically (after penicillin). This drug is a water soluble, basic substance having an aminoglycoside structure and showing strong activity against a wide range of gram-positive and gram-negative bacteria including Mycobacterium. Streptomycin is the first choice among antituberculotic antibiotics and has been used for the therapy of Spirochaeta and Treponema infections.
UsesTriacetine
UsesAntibiotic substance produced by aerobic fermentation. Antibacterial (tuberculostatic).
Streptomycin sulfate is a sulfate salt of streptomycin that is a protein synthesis inhibitor. Streptomycin is an antibiotic drug, the first of a class of drugs called aminoglycosides to be discovered, and was the first antibiotic remedy for tuberculosis.
Related reactions
0 records
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Compound notes
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